Topoisomerasi
Le topoisomerasi sono enzimi che regolano la topologia del DNA durante processi come la replicazione, la trascrizione e la segregazione cromosomica, introducendo rotture transitorie nei filamenti di DNA per alleviare lo stress torsionale. Gli inibitori della topoisomerasi interferiscono con questo processo, portando all'accumulo di rotture nel DNA e all'induzione della morte cellulare, in particolare nelle cellule a rapida divisione. Questi inibitori sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori della topoisomerasi di alta qualità per supportare la tua ricerca sulla replicazione del DNA, la terapia del cancro e la regolazione del ciclo cellulare.
Trovati 141 prodotti di "Topoisomerasi"
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CAS:SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Formula:C69H97NO20S2Purezza:98%Colore e forma:SolidPeso molecolare:1324.63ARN-21934
CAS:ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.Formula:C21H24N6Purezza:99.8%Colore e forma:SolidPeso molecolare:360.46Ref: TM-T36968
1mg62,00€2mg89,00€5mg135,00€10mg212,00€25mg373,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)149,00€Anticancer agent 216
CAS:Anticanceragent 216 (34A) is a camptothecin compound with IC50 values of 9.6 nM for MCF-7 cells and 11.6 nM for MDA-MB-231 cells.Formula:C23H21N3O6Colore e forma:SolidPeso molecolare:435.43Ac-Exatecan
CAS:Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.Formula:C26H24FN3O5Purezza:97.09%Colore e forma:SolidPeso molecolare:477.48Pradofloxacin
CAS:Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.Formula:C21H21FN4O3Purezza:98.76%Colore e forma:SolidPeso molecolare:396.41Topoisomerase inhibitor 2
CAS:Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].Formula:C23H23N5O4Purezza:98%Colore e forma:SolidPeso molecolare:433.46Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFormula:C23H15Br2FN2Purezza:98%Colore e forma:SolidPeso molecolare:498.19NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Formula:C30H30F4N4O7Purezza:98%Colore e forma:SolidPeso molecolare:634.58Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Formula:C21H19F3N4O6SPurezza:99.18%Colore e forma:SolidPeso molecolare:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFormula:C22H18ClFN2O4Purezza:98%Colore e forma:SolidPeso molecolare:428.84Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:348.44Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Formula:C25H27N3O7Colore e forma:SolidPeso molecolare:481.498Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Formula:C23H22FN3O4Colore e forma:SolidPeso molecolare:423.44Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purezza:98.47%Colore e forma:SolidPeso molecolare:447.48TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formula:C22H21N3O4Purezza:98.77%Colore e forma:SolidPeso molecolare:391.42Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Formula:C20H21N3OSColore e forma:SolidPeso molecolare:351.47Karenitecin
CAS:<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formula:C25H28N2O4SiPurezza:98%Colore e forma:SolidPeso molecolare:448.59LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Formula:C22H19FN2O5Colore e forma:SolidPeso molecolare:410.4Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Formula:C29H28N4O11Purezza:98%Colore e forma:SolidPeso molecolare:608.55
