Sirtuina
Le sirtuine sono una famiglia di deacetilasi dipendenti dal NAD+ che svolgono un ruolo cruciale nella regolazione di processi cellulari come la riparazione del DNA, l'invecchiamento, il metabolismo e la resistenza allo stress. Le sirtuine influenzano la riparazione del DNA deacetilando le proteine coinvolte nelle vie di riparazione, modulandone così l'attività. Gli inibitori e gli attivatori delle sirtuine sono strumenti preziosi nella ricerca sull'invecchiamento, il cancro e le malattie metaboliche, dove la regolazione della riparazione del DNA e della longevità cellulare è di interesse. Presso CymitQuimica, offriamo una gamma di modulatori di sirtuine di alta qualità per supportare la tua ricerca sulla riparazione del DNA, l'invecchiamento cellulare e la regolazione metabolica.
Trovati 95 prodotti per "Sirtuina".
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SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Formula:C22H20N4OS2Purezza:99.52% - 99.75%Colore e forma:SolidPeso molecolare:420.55Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Formula:C26H22N2O2Purezza:97.12% - 99.96%Colore e forma:Yellow SolidPeso molecolare:394.4651Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Formula:C30H42O7Purezza:98.06% - 99.98%Colore e forma:White SolidPeso molecolare:514.6503Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Formula:C15H10O6Purezza:94.14% - 99.05%Colore e forma:Yellow SolidPeso molecolare:286.2363MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Formula:C21H16BrCl2FN2O6S2Purezza:99.95% - 99.96%Colore e forma:White SolidPeso molecolare:626.3Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Formula:C28H27N7O2S2Purezza:99.57% - 99.84%Colore e forma:SolidPeso molecolare:557.69SIRT6 activator 12q
CAS:SIRT6 activator 12q is a SIRT6 activator; EC50=5.3 μM; allosteric modulator; metabolism and aging research.Formula:C31H22N2O2Purezza:98.53%Colore e forma:White SolidPeso molecolare:454.5186SIRT2-IN-11
CAS:SIRT2-IN-11 is a selective SIRT2 inhibitor; IC50=12 nM; increases tubulin acetylation; cancer research tool.Formula:C21H22N2OColore e forma:White SolidPeso molecolare:318.4122SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Formula:C21H22N6OS2Purezza:97.6%Colore e forma:Yellow SolidPeso molecolare:438.569SIRT3 activator 2
CAS:SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColore e forma:SolidPeso molecolare:492.5SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Formula:C18H15N3O4SPurezza:99.97%Colore e forma:White SolidPeso molecolare:369.39SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Formula:C21H28N6O4SPurezza:99.84%Colore e forma:SolidPeso molecolare:460.55SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Formula:C18H12Cl2N2O3SPurezza:99.38% - 99.87%Colore e forma:SolidPeso molecolare:407.27SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Formula:C24H15N3O2SColore e forma:SolidPeso molecolare:409.462-APQC
CAS:2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.Formula:C23H24FN5OPurezza:99.88%Colore e forma:White SolidPeso molecolare:405.468SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Formula:C21H14ClN3O3SPurezza:99.33%Colore e forma:SolidPeso molecolare:423.87SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Formula:C19H14N2O6Purezza:98.77%Colore e forma:SolidPeso molecolare:366.3243SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Formula:C31H39FN6O6S2Purezza:97.8%Colore e forma:White SolidPeso molecolare:674.806SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Formula:C40H54N8O6SPurezza:98%Colore e forma:SolidPeso molecolare:774.97Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Formula:C20H17N3O2Purezza:99.1% - 99.87%Colore e forma:White SolidPeso molecolare:331.37
