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Sirtuina

Sirtuina

Le sirtuine sono una famiglia di deacetilasi dipendenti dal NAD+ che svolgono un ruolo cruciale nella regolazione di processi cellulari come la riparazione del DNA, l'invecchiamento, il metabolismo e la resistenza allo stress. Le sirtuine influenzano la riparazione del DNA deacetilando le proteine coinvolte nelle vie di riparazione, modulandone così l'attività. Gli inibitori e gli attivatori delle sirtuine sono strumenti preziosi nella ricerca sull'invecchiamento, il cancro e le malattie metaboliche, dove la regolazione della riparazione del DNA e della longevità cellulare è di interesse. Presso CymitQuimica, offriamo una gamma di modulatori di sirtuine di alta qualità per supportare la tua ricerca sulla riparazione del DNA, l'invecchiamento cellulare e la regolazione metabolica.

Trovati 95 prodotti per "Sirtuina".

prodotti per pagina.
  • Sirtuin modulator 1
    Targetmol
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    Sirtuin modulator 1

    CAS:
    Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.
    Formula:C31H32ClN5O2S2
    Purezza:99.63%
    Colore e forma:Yellow Solid
    Peso molecolare:606.201

    Ref: TM-T12922

  • SIRT-IN-1
    Targetmol
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    SIRT-IN-1

    CAS:
    SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
    Formula:C19H27N5O2S
    Purezza:99.29%
    Colore e forma:Solid
    Peso molecolare:389.515

    Ref: TM-T12918

  • SIRT5 inhibitor 7
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    SIRT5 inhibitor 7

    CAS:
    SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.
    Formula:C28H32ClN7O3S
    Purezza:99.77%
    Colore e forma:Solid
    Peso molecolare:582.12

    Ref: TM-T78803

  • Epigenetic factor-IN-1
    Targetmol
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    Epigenetic factor-IN-1

    CAS:
    Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.
    Formula:C32H34FN5O6S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:667.77

    Ref: TM-T82458

  • SIRT6 modulator-1
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    SIRT6 modulator-1

    CAS:
    SIRT6modulator-1 is a modulator of SIRT6.
    Formula:C12H13N7OS3
    Peso molecolare:367.473

    Ref: TM-T214778

  • Logo CymitQuimica
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    IMU-856

    CAS:
    IMU-856 is an orally active, systemic small molecule modulator of SIRT6. It effectively and selectively inhibits the deacetylase activity of SIRT6 while enhancing the protein levels of SIRT6. IMU-856 has the potential to restore intestinal barrier function and can be used in research on celiac disease.
    Formula:C30H38F3N7O2
    Peso molecolare:585.68

    Ref: TM-T214571

  • MC3138
    Targetmol
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    MC3138

    CAS:
    MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.
    Formula:C25H25NO6
    Purezza:99.57%
    Colore e forma:Yellow Solid
    Peso molecolare:435.47

    Ref: TM-T88662

  • Logo CymitQuimica
    Targetmol
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    Sirtuin-IN-1

    CAS:
    Sirtuin-IN-1 (Compound 18) is an inhibitor of SIRT1/2, with IC50 values of 6.2 μM for SIRT1 and 4.2 μM for SIRT2. It can induce G1 phase cell cycle arrest and demonstrates effective anticancer activity against glioma.
    Formula:C24H28N4O4
    Peso molecolare:436.51

    Ref: TM-T213942

  • SIRT2-IN-14
    Targetmol
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    SIRT2-IN-14

    CAS:
    **SIRT2-IN-14 (Compound 78)** is a selective SIRT2 inhibitor, demonstrating an IC50 value of 0.196 μM [1].
    Formula:C26H21N3O4
    Colore e forma:Solid
    Peso molecolare:439.46

    Ref: TM-T87402

  • Sirtuin-IN-2
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    Sirtuin-IN-2

    Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.
    Formula:C28H46N8O6S
    Colore e forma:Solid
    Peso molecolare:622.78

    Ref: TM-T201797

  • DCHC
    Targetmol
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    DCHC

    CAS:
    DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.
    Formula:C15H8Cl2O3
    Colore e forma:Solid
    Peso molecolare:307.128

    Ref: TM-T204498

  • SIRT-IN-6
    Targetmol
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    SIRT-IN-6

    CAS:
    SIRT-IN-6 (Compound 14) is a pan-SIRT1/2/3 inhibitor (IC50 >50 μM) used in studies of sirtuin metabolism, inflammation, and neurodegeneration.
    Formula:C7H4ClN3OS
    Colore e forma:Solid
    Peso molecolare:213.644

    Ref: TM-T204971

  • SIRT1-IN-5
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    SIRT1-IN-5

    CAS:
    SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.
    Formula:C21H17N3O3S
    Purezza:99.97%
    Colore e forma:Solid
    Peso molecolare:391.443

    Ref: TM-T204465

  • SIRT6 activator 2
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    SIRT6 activator 2

    CAS:
    SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.
    Formula:C23H23N3O6
    Colore e forma:Solid
    Peso molecolare:437.45

    Ref: TM-T200625

  • CL5D
    Targetmol
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    CL5D

    CAS:
    CL5D is an activator of the protein deacetylase SIRT6. It significantly enhances the deacetylase activity and catalytic efficiency of SIRT6. CL5D modulates SIRT6 activity by promoting its conformational changes, particularly relying on the Arg-65 residue. This compound can be used to study the activation mechanism of SIRT6 and its roles in metabolism, DNA repair, and aging.
    Formula:C29H11Cl7N2O6
    Peso molecolare:731.58

    Ref: TM-T211010