Recettore degli androgeni
Il recettore degli androgeni (AR) è un recettore ormonale nucleare che viene attivato dal legame con gli androgeni, come il testosterone e il diidrotestosterone. Questo recettore svolge un ruolo cruciale nello sviluppo e nel mantenimento delle caratteristiche maschili, nonché nella regolazione di diversi processi fisiologici, tra cui la crescita muscolare, la libido e la densità ossea. Gli inibitori del recettore degli androgeni sono ampiamente studiati nel contesto del cancro alla prostata, dove la segnalazione dell'AR è spesso sovraregolata. Presso CymitQuimica, offriamo una gamma di modulatori del recettore degli androgeni di alta qualità per supportare la tua ricerca in endocrinologia, biologia del cancro e regolazione ormonale.
Trovati 228 prodotti di "Recettore degli androgeni"
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BMS-986365
CAS:BMS-986365 (CC-94676) is an orally available, selective and highly potent AR degrader with potential anticancer activity that inhibits AR signaling and suppresses tumor growth for the study of prostate cancer.Formula:C41H45F3N8O5SPurezza:98.69% - 99.96%Colore e forma:SoildPeso molecolare:818.91ORM-15341
CAS:<p>ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)</p>Formula:C19H17ClN6O2Purezza:98.01%Colore e forma:SolidPeso molecolare:396.83Vosilasarm
CAS:RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Formula:C20H16ClN5O2Purezza:99.01% - 99.6%Colore e forma:A Crystalline SolidPeso molecolare:393.82Topilutamide
CAS:Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.Formula:C13H11F6N3O5Purezza:98.77% - 99.24%Colore e forma:SolidPeso molecolare:403.23Nilutamide
CAS:<p>Nilutamide, a nonsteroidal anti-androgen, treats prostate cancer by blocking androgen receptors, not affecting other hormone receptors.</p>Formula:C12H10F3N3O4Purezza:98.67% - 99.78%Colore e forma:Crystalline SolidPeso molecolare:317.22Chlormadinone acetate
CAS:Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Formula:C23H29ClO4Purezza:98.11% - 98.97%Colore e forma:Crystals From Menthanol Or Ether Crystalline SolidPeso molecolare:404.93Bicalutamide
CAS:<p>Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the</p>Formula:C18H14F4N2O4SPurezza:98% - 99.87%Colore e forma:Off-White Crystalline SolidPeso molecolare:430.37Ligandrol
CAS:Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.Formula:C14H12F6N2OPurezza:99.94% - >99.99%Colore e forma:SolidPeso molecolare:338.253,3'-Diindolylmethane
CAS:3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Formula:C17H14N2Purezza:99.09%Colore e forma:SolidPeso molecolare:246.31Zanoterone
CAS:<p>Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders and</p>Formula:C23H32N2O3SPurezza:99.03% - 99.92%Colore e forma:SoildPeso molecolare:416.58Allylestrenol
CAS:Allylestrenol (Gestanin) is a synthetic steroid with progestational activity.Formula:C21H32OPurezza:>99.99%Colore e forma:White Crystalline PowderPeso molecolare:300.48Luxdegalutamide
CAS:Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades theFormula:C45H54FN7O6Purezza:99.95%Colore e forma:SolidPeso molecolare:807.95UT-155
CAS:UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).Formula:C20H15F4N3O2Purezza:98.94%Colore e forma:SolidPeso molecolare:405.35Flutamide
CAS:<p>Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.</p>Formula:C11H11F3N2O3Purezza:99.6% - 99.96%Colore e forma:SolidPeso molecolare:276.21UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormula:C15H12F4N4O2Purezza:98.12%Colore e forma:SolidPeso molecolare:356.27Adrenocorticotropic hormone TFA
Adrenocorticotropic hormone TFA is an adrenocorticotropic hormone involved in neurohormonal regulation of the body.Purezza:99.71%Colore e forma:Odour SolidN-Desmethyl-Apalutamide
CAS:N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.Formula:C20H13F4N5O2SPurezza:98.6%Colore e forma:SolidPeso molecolare:463.41Ostarine
CAS:<p>Ostarine (MK-2866) is a non-steroidal SARM mimicking testosterone to boost muscle growth, libido, fertility, and may help prevent muscle wasting in cancer.</p>Formula:C19H14F3N3O3Purezza:99.69% - 99.90%Colore e forma:SolidPeso molecolare:389.33AS-601811
CAS:AS-601811 is a bio-active chemical.Formula:C15H17NOPurezza:98.05% - 99.58%Colore e forma:SolidPeso molecolare:227.3Adrenosterone
CAS:Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.Formula:C19H24O3Purezza:98.13% - 98.29%Colore e forma:SolidPeso molecolare:300.39Spironolactone
CAS:Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.Formula:C24H32O4SPurezza:99.87%Colore e forma:White PowderPeso molecolare:416.57SK33
CAS:SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.Formula:C20H13F9N2O3Purezza:99.55%Colore e forma:SolidPeso molecolare:500.31AR antagonist 1
CAS:AR antagonist 1 is a potent antagonist of the androgen receptor.Formula:C15H19ClN2OPurezza:99.07%Colore e forma:SolidPeso molecolare:278.78Andarine
CAS:Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).Formula:C19H18F3N3O6Purezza:99.88%Colore e forma:Pale Yellow SolidPeso molecolare:441.36Cyproterone acetate
CAS:Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues andFormula:C24H29ClO4Purezza:98.43% - 99.83%Colore e forma:Crystals From Diisopropyl Ether OdourPeso molecolare:416.94ACP-105
CAS:<p>ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen</p>Formula:C16H19ClN2OPurezza:99.89%Colore e forma:SolidPeso molecolare:290.79Medroxyprogesterone Acetate
CAS:<p>Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. Farlutin is a long-acting contraceptive.</p>Formula:C24H34O4Purezza:99.05% - 99.44%Colore e forma:White PowderPeso molecolare:386.522,2,5,7,8-Pentamethyl-6-Chromanol
CAS:2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation andFormula:C14H20O2Purezza:98.72%Colore e forma:SolidPeso molecolare:220.31Proxalutamide
CAS:Proxalutamide is a potent antagonist of the androgen receptor (AR).Formula:C24H19F4N5O2SPurezza:99.11%Colore e forma:SolidPeso molecolare:517.5Octinoxate
CAS:<p>Octinoxate (Octyl 4-methoxycinnamate) is an organic compound that is used is in sunscreens and other cosmetics to absorb UV-B rays from the sun.</p>Formula:C18H26O3Purezza:99.93%Colore e forma:Less To Pale Yellow Viscous Liquid (Ntp 1992) Physical Description Colorless To Pale Yellow Viscous Liquid (Ntp 1992)Peso molecolare:290.40BWA-6047
BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.Formula:C42H46ClN5O7Colore e forma:SolidPeso molecolare:767.30858Nuclear Receptor Compound Library
<p>A unique collection of 531 nuclear receptor signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidARD-2585
CAS:ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formula:C41H43ClN8O5Colore e forma:SolidPeso molecolare:763.28Tibolone
CAS:Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFormula:C21H28O2Purezza:99.70% - 99.71%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:312.45TD-802
CAS:TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.Formula:C52H61ClN10O6Colore e forma:SolidPeso molecolare:957.56K2-B4-5e
<p>K2-B4-5e is a PROTAC compound designed to target the degradation of BRD4 and androgen receptor (AR) through a KLHDC2-based E3 ligase mechanism. It effectively induces rapid and potent degradation of BET family proteins and AR within cells.</p>Formula:C52H49ClN8O6SPeso molecolare:948.31843Cl-4AS-1
CAS:steroidal androgen receptor agonistFormula:C26H33ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:441.01Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Formula:C14H18O4Purezza:98.62%Colore e forma:SolidPeso molecolare:250.29PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Formula:C43H49ClN6O5Colore e forma:SolidPeso molecolare:765.3399,10-Dihydrophenanthrene
CAS:9,10-Dihydrophenanthrene has inhibitory activity against the androgen receptor and can be used in related research in the field of life sciences.Formula:C14H12Purezza:98.76%Colore e forma:SolidPeso molecolare:180.25ODM-204
CAS:ODM-204 is novel nonsteroidal dual inhibitor of both androgen receptor and CYP17A1 enzyme(IC50s of 80 nM and 22 nM, respectively).Formula:C20H21F3N4Purezza:98%Colore e forma:SolidPeso molecolare:374.40Adrenocorticotropic hormone
CAS:ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.Colore e forma:SolidLambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Formula:C20H28O3Purezza:98%Colore e forma:SolidPeso molecolare:316.441ARD-69
ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.Formula:C62H74ClFN8O7SColore e forma:SolidPeso molecolare:1129.83Faznolutamide
CAS:Faznolutamide is an antiandrogen agent [1] [2] .Formula:C19H17FN4O2SColore e forma:SolidPeso molecolare:384.43PROTAC AR Degrader-4 TFA
PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.Formula:C45H68F3N3O11Colore e forma:SolidPeso molecolare:884.03Inocoterone acetate
CAS:Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.Formula:C18H26O3Colore e forma:SolidPeso molecolare:290.40Linuron
CAS:Linuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Formula:C9H10Cl2N2O2Purezza:99.08%Colore e forma:White Crystalline Solid Linuron Is A Colorless Crystals Non Corrosive Used As An HerbicidePeso molecolare:249.09LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Colore e forma:Odour Solid3-Cl-Pyridine-amide-acrylaldehyde-piperazine
3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.Colore e forma:Odour Solid
