NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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Mangiferin
CAS:<p>Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.</p>Formula:C19H18O11Purezza:99.78% - 99.86%Colore e forma:Light Yellow PowderPeso molecolare:422.34Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formula:C7H5NaO3Purezza:99.36% - 99.92%Colore e forma:White Solid AmorphousPeso molecolare:160.11GSK3145095
CAS:GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.Formula:C20H17F2N5O2Purezza:99.50%Colore e forma:SolidPeso molecolare:397.38Sinomenine hydrochloride
CAS:<p>Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.</p>Formula:C19H24ClNO4Purezza:99.43%Colore e forma:SolidPeso molecolare:365.851Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Formula:C27H30O7Purezza:95.84% - 99.4%Colore e forma:SolidPeso molecolare:466.52GLPG2534
CAS:<p>GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.</p>Formula:C21H24N6O4Purezza:99.51% - 99.61%Colore e forma:SolidPeso molecolare:424.45Indacaterol maleate
CAS:<p>Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.</p>Formula:C28H32N2O7Purezza:99.03% - 99.67%Colore e forma:SolidPeso molecolare:508.56Theophylline
CAS:<p>Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central</p>Formula:C7H8N4O2Purezza:99.65% - 99.98%Colore e forma:White Solid PowderPeso molecolare:180.164-Hydroxychalcone
CAS:<p>4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.</p>Formula:C15H12O2Purezza:99.75%Colore e forma:Yellow PowderPeso molecolare:224.25DCZ0415
CAS:<p>DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.</p>Formula:C23H20N2O2Purezza:99.34% - 99.95%Colore e forma:SolidPeso molecolare:356.42Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formula:C9H8O4Purezza:99.78% - 99.91%Colore e forma:White Solid CrystallinePeso molecolare:180.16Sulindac
CAS:<p>Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.</p>Formula:C20H17FO3SPurezza:99.09% - 99.15%Colore e forma:Yellow SolidPeso molecolare:356.41Erdosteine
CAS:<p>Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.</p>Formula:C8H11NO4S2Purezza:99.43% - 99.94%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:249.31Dihydroartemisinin
CAS:<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formula:C15H24O5Purezza:98% - 99.41%Colore e forma:White SolidPeso molecolare:284.35Guaiacol
CAS:<p>Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.</p>Formula:C7H8O2Purezza:99.95%Colore e forma:Colourless To Pale Yellow Solid CrystallinePeso molecolare:124.14Methylthiouracil
CAS:<p>Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.</p>Formula:C5H6N2OSPurezza:99.89% - >99.99%Colore e forma:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecolare:142.18AZ1495
CAS:<p>AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.</p>Formula:C21H31N5O2Purezza:98.81%Colore e forma:SolidPeso molecolare:385.5Naringin dihydrochalcone
CAS:<p>Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.</p>Formula:C27H34O14Purezza:99.07% - 99.73%Colore e forma:Solid PowderPeso molecolare:582.55Asatone
CAS:<p>Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).</p>Formula:C24H32O8Purezza:99.84% - 99.92%Colore e forma:SolidPeso molecolare:448.51α-Lipoic Acid
CAS:<p>α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.</p>Formula:C8H14O2S2Purezza:98.39% - 99.73%Colore e forma:Forms Yellowish Flakes Light Yellow To Yellow PowderPeso molecolare:206.33Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82TBK1/IKKε-IN-2
CAS:<p>TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.</p>Formula:C26H27N5O3Purezza:98.89%Colore e forma:SolidPeso molecolare:457.525-Aminosalicylic Acid
CAS:<p>5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1 (PAK1) and NF-Κb. High-Quality, Low-Cost!</p>Formula:C7H7NO3Purezza:98.88% - 99.49%Colore e forma:Purplish-Tan Solid PowderPeso molecolare:153.14IRAK4-IN-4
CAS:<p>IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4)</p>Formula:C22H16N2O2Purezza:99.52%Colore e forma:SolidPeso molecolare:340.37RIPK1-IN-7
CAS:<p>RIPK1-IN-7: Strong, selective RIPK1 inhibitor (Kd=4 nM, IC50=11 nM) with great antimetastasis effects in B16 melanoma.</p>Formula:C25H22F3N5O2Purezza:98.02% - 98.18%Colore e forma:SolidPeso molecolare:481.47Theophylline monohydrate
CAS:<p>Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium</p>Formula:C7H8N4O2·H2OPurezza:99.78%Colore e forma:SolidPeso molecolare:198.18Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formula:C14H23ClN2OPurezza:99.81% - 99.92%Colore e forma:White Crystal PowderPeso molecolare:270.798Oxaprozin
CAS:<p>Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.</p>Formula:C18H15NO3Purezza:98.53%Colore e forma:SolidPeso molecolare:293.32Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purezza:99.45%Colore e forma:SolidPeso molecolare:212.2Mevastatin
CAS:<p>Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.</p>Formula:C23H34O5Purezza:99.12%Colore e forma:White-Yellowish To Yellow Powder Solid PowderPeso molecolare:390.51(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formula:C22H23NOPurezza:99.94%Colore e forma:SolidPeso molecolare:317.42DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formula:C17H27NO3Purezza:99.91%Colore e forma:SolidPeso molecolare:293.4Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formula:C14H22N2OPurezza:99.95% - >99.99%Colore e forma:Needles From Benzene Or Alcohol SolidPeso molecolare:234.34Metaxalone
CAS:<p>Metaxalone, sold as Skelaxin by King Pharmaceuticals, is a muscle relaxant for pain from strains and sprains.</p>Formula:C12H15NO3Purezza:98.84% - 99.94%Colore e forma:White To Almost White Crystalline Powder SolidPeso molecolare:221.25Articaine hydrochloride
CAS:<p>Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.</p>Formula:C13H21ClN2O3SPurezza:99.76%Colore e forma:White Crystalline PowderPeso molecolare:320.84DRI-C21045
CAS:<p>Dri-c21045 inhibits NF-kB (IC50=17.1μM) and B cell proliferation (IC50=4.5μM), selectively blocking CD40-CD40L interaction (IC50=0.17μM).</p>Formula:C32H24N2O7SPurezza:97.20%Colore e forma:SolidPeso molecolare:580.61IMD-0560
CAS:<p>IMD-0560 is a novel inhibitor of IκB kinase β.</p>Formula:C15H8BrF6NO2Purezza:99.51%Colore e forma:SolidPeso molecolare:428.12Ergolide
CAS:<p>Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.</p>Formula:C17H22O5Purezza:99.64%Colore e forma:SolidPeso molecolare:306.35CDDO-dhTFEA
CAS:CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor.Formula:C33H45F3N2O3Purezza:95.61% - 99.59%Colore e forma:SolidPeso molecolare:574.72Baicalin
CAS:<p>Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIV</p>Formula:C21H18O11Purezza:90.08% - 99.32%Colore e forma:Yellow PowderPeso molecolare:446.36BAY-985
CAS:<p>BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.</p>Formula:C27H30F3N9OPurezza:99.62%Colore e forma:SolidPeso molecolare:553.58SN50 acetate (213546-53-3 free base)
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.Formula:C131H234N36O31SPurezza:99.86%Colore e forma:SolidPeso molecolare:2841.55Sulfasalazine
CAS:<p>Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative. Sulfasalazine induces ferroptosis and inhibits NF-κB. Cost effective and quality assured.</p>Formula:C18H14N4O5SPurezza:98.00% - 99.28%Colore e forma:Minute Brownish-Yellow CrystalsPeso molecolare:398.39NIK SMI1
CAS:<p>NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).</p>Formula:C20H19N3O4Purezza:99.04% - 99.99%Colore e forma:SolidPeso molecolare:365.38PROTAC IRAK4 ligand-4
CAS:<p>PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.</p>Formula:C24H26F2N6O3Colore e forma:SolidPeso molecolare:484.5Helenalin
CAS:<p>Helenalin: anti-inflammatory sesquiterpene, inhibits NF-κB by alkylating p65 cysteine groups, blocks DNA binding.</p>Formula:C15H18O4Purezza:98%Colore e forma:SolidPeso molecolare:262.3TH023
<p>TH023 is an inhibitor of the TLR4 signaling pathway, specifically targeting the formation of TLR4 homodimers. In HEK-Blue hTLR4 cells, TH023 suppresses the secretion of embryonic alkaline phosphatase with an IC50 of 0.354 μM and inhibits NO expression in RAW264.7 cells, with an IC50 of 1.61 μM. Additionally, TH023 inhibits the activation of NF-κB and reduces the nuclear translocation of NF-κB p65. The compound demonstrates anti-inflammatory effects in a mouse model of LPS-induced acute sepsis and improves lung injury in mice.</p>Formula:C22H21ClF2N4OColore e forma:SolidPeso molecolare:430.88IKK-IN-3
CAS:<p>IKK-IN-3: potent IKK2 inhibitor (IC50=19nM), affects IKK1(IC50=400nM).</p>Formula:C17H17N5SColore e forma:SolidPeso molecolare:323.42NF-κΒ activator 1
CAS:<p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>Formula:C16H11FN2O2SPurezza:99.58%Colore e forma:SolidPeso molecolare:314.33HS-243
CAS:<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Formula:C17H16N4O3Purezza:98.62%Colore e forma:SolidPeso molecolare:324.33(R)-(-)-Ibuprofen
CAS:(R)-(-)-Ibuprofen ((R)-Ibuprofen) is the R enantiomer of Ibuprofen and inhibits NF-κB activation.Formula:C13H18O2Purezza:99.86%Colore e forma:SolidPeso molecolare:206.28CIB-1476
<p>CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.</p>Formula:C28H28N2O6SColore e forma:SolidPeso molecolare:520.6Coronalolic acid
CAS:<p>Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.</p>Formula:C30H46O4Purezza:98%Colore e forma:SolidPeso molecolare:470.68Cyclo(L-Pro-L-Val)
CAS:<p>Cyclo(L-Pro-L-Val), from Mycobacterium spp., has anti-inflammatory effects, hinders phytopathogens, and suppresses IKKα, NF-κB, iNOS, and COX-2 activation.</p>Formula:C10H16N2O2Purezza:98.18%Colore e forma:SolidPeso molecolare:196.25PROTAC IRAK4 degrader-12
CAS:<p>PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)</p>Formula:C46H50ClF2N11O6Colore e forma:SolidPeso molecolare:926.41PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Colore e forma:Odour SolidPratensein
CAS:<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Formula:C16H12O6Purezza:99.90%Colore e forma:SolidPeso molecolare:300.26Anti-inflammatory agent 51
CAS:<p>Anti-inflammatory agent 51 amide/sulfonamide anti-inflammatory and anti-tumor activity inhibition of NF-κB activation acute lung injury and ulcerative colitis.</p>Formula:C22H22N6O6SPurezza:99.46%Colore e forma:SoildPeso molecolare:498.51Gliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:326.39RIPK1-IN-27
<p>RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.</p>Formula:C27H28N4O3Colore e forma:SolidPeso molecolare:456.54EN450
CAS:<p>EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.</p>Formula:C11H13ClN2O3SPurezza:99.72%Colore e forma:SoildPeso molecolare:288.75Antidesmone
CAS:<p>Antidesmone from Ajuga decumbens inhibits acute lung injury by modulating MAPK and NF-κB.</p>Formula:C19H29NO3Purezza:98%Colore e forma:SolidPeso molecolare:319.44Aloenin aglycone
CAS:<p>Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate.</p>Formula:C13H12O5Purezza:98%Colore e forma:SolidPeso molecolare:248.23Eupenicisirenin C
CAS:Eupenicisirenin C (compound 1), a sirenin derivative, exhibits strong NF-κB inhibitory activities and suppresses the cGAS-STING pathway. Additionally, Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells [1].Formula:C13H18O4Peso molecolare:238.28NBD peptide
CAS:<p>NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.</p>Formula:C62H88N14O20Colore e forma:SolidPeso molecolare:1349.44SU1261
<p>SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.</p>Colore e forma:Odour SolidPS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Formula:C17H13Cl3N4OPurezza:98%Colore e forma:SolidPeso molecolare:395.67Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formula:C18H19F3N2O2SePeso molecolare:432.05638LY2409881
CAS:<p>LY2409881 is a selective IκB kinase β ( IKK2 ) inhibitor with an IC 50 of 30 nM.</p>Formula:C24H29ClN6OSColore e forma:SolidPeso molecolare:485.05Salicortin
CAS:<p>Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.</p>Formula:C20H24O10Purezza:98%Colore e forma:SolidPeso molecolare:424.40TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Formula:C31H36F2N8O4Colore e forma:SolidPeso molecolare:622.678Nasunin
CAS:<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Formula:C42H47ClO23Colore e forma:SolidPeso molecolare:955.26Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formula:C20H28O6Colore e forma:SolidPeso molecolare:364.43Diprovocim-1
CAS:<p>Diprovocim-1: TLR1/2 agonist; triggers TNF-α in THP-1 cells; boosts ovalbumin IgG1 & CTLs against tumors with anti-PD-L1 in mice.</p>Formula:C56H56N6O6Colore e forma:SolidPeso molecolare:909.1SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formula:C129H230N36O29S·XCF3COOHColore e forma:SolidPeso molecolare:2781.5 (free base)Mesalamine impurity P
CAS:<p>Mesalamine impurity P, a 5-Aminosalicylic acid derivative, is a PPARγ agonist, inhibiting PAK1 and NF-κB.</p>Formula:C13H11NO6SColore e forma:SolidPeso molecolare:309.30Licoagrochalcone C
CAS:<p>Licoagrochalcone C, a flavonoid, inhibits NF-κB and NO production effectively.</p>Formula:C21H22O5Colore e forma:SolidPeso molecolare:354.47-O-Methylaloeasinol
CAS:<p>7-O-Methylaloeasinol is a useful organic compound for research related to life sciences. The catalog number is T126468 and the CAS number is 105317-69-9.</p>Formula:C20H26O9Colore e forma:SolidPeso molecolare:410.419Anti-inflammatory agent 7
<p>Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.</p>Formula:C36H40N4O9Colore e forma:SolidPeso molecolare:672.72COX-2-IN-48
<p>COX-2-IN-48 (5-25) serves as an inhibitor of COX-2, exhibiting an IC50 of 51.7 nM against human COX-2. It displays anti-inflammatory and analgesic effects in various rodent models through inhibition of the NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.</p>Colore e forma:Odour SolidNLRP3-IN-51
<p>NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.</p>Colore e forma:Odour SolidNF-κB-IN-9
<p>NF-κB-IN-9, a nuclear factor kappa B (NF-κB) targeting sonosensitizer with excitation and emission wavelengths (λex/λem) of 489/628 nm, features dual</p>Formula:C62H50N4O4SColore e forma:SolidPeso molecolare:947.15Murrayafoline A
CAS:<p>Murrayafoline A is a useful organic compound for research related to life sciences. The catalog number is T124835 and the CAS number is 4532-33-6.</p>Formula:C14H13NOColore e forma:SolidPeso molecolare:211.264Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Colore e forma:Solid12-Oxo phytodienoic acid
CAS:<p>12-oxo PDA boosts alkaloid production in E. californica, enhances B. dioica tendril curls, and blocks JA-induced cell death in A. fru mutants.</p>Formula:C18H28O3Purezza:98%Colore e forma:SolidPeso molecolare:292.41MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purezza:99.25% - 99.84%Colore e forma:SolidPeso molecolare:464.63-(2-Hydroxyethyl) thio withaferin A
<p>3-(2-Hydroxyethyl) thio withaferin A, a steroidal lactone, blocks NF-kB, targets vimentin, and inhibits EPCR shedding.</p>Formula:C30H44O7SColore e forma:SolidPeso molecolare:548.73RIPK1-IN-25
<p>RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.</p>Colore e forma:Odour SolidTranscription Factor-Targeted Compound Library
<p>Well-chosen xnum compounds with unique structures targeting transcription factor;</p>Colore e forma:Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Colore e forma:Odour SolidIKKγ NBD Inhibitory Peptide
CAS:<p>A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF</p>Formula:C170H259N49O42S1Purezza:98%Colore e forma:SolidPeso molecolare:3693.3SjDX5-271
CAS:<p>SjDX5-271 is a 3 kDa peptide that inhibits the TLR4/MyD88/NF-κB signaling pathway. It induces cell polarization, alleviates liver inflammation, and protects mice from liver ischemia-reperfusion injury.</p>Formula:C137H215N47O49SColore e forma:SolidPeso molecolare:3336.52R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Formula:C22H19N3O2S2Colore e forma:SolidPeso molecolare:421.54CAY10512
CAS:<p>CAY10512, a resveratrol analog, is 100x more potent, inhibiting NF-κB with an IC50 of 0.15 μM versus resveratrol's 20 μM.</p>Formula:C15H13FOColore e forma:SolidPeso molecolare:228.266NF-κB Signaling Compound Library
<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>Colore e forma:Odour Solid17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formula:C22H32O3Colore e forma:SolidPeso molecolare:344.495CAY10657
CAS:<p>CAY10657 has a wide range of applications in life science related research.</p>Formula:C17H20N4O3SColore e forma:SolidPeso molecolare:360.43Lemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Formula:C15H24OPurezza:98%Colore e forma:SolidPeso molecolare:220.35R1-ICR-5
CAS:<p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>Formula:C54H70N8O7S2Colore e forma:SolidPeso molecolare:1007.31N-Acetyldopamine dimer-2
CAS:<p>Compound 2, an N-acetyldopamine dimer from Periostracum Cicadae, exhibits antioxidant and anti-inflammatory properties.</p>Formula:C20H20N2O6Colore e forma:SolidPeso molecolare:384.38
