NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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PS 1145 dihydrochloride
CAS:<p>IκB kinase (IKK) inhibitor</p>Formula:C17H13Cl3N4OPurezza:98%Colore e forma:SolidPeso molecolare:395.67Nasunin
CAS:<p>Delphanin, also known as Nasunin, is an anthocyanin isolated as purple colored crystals from eggplant peels.</p>Formula:C42H47ClO23Colore e forma:SolidPeso molecolare:955.26TBK1/IKKε-IN-6
CAS:<p>TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.</p>Formula:C31H36F2N8O4Colore e forma:SolidPeso molecolare:622.678Ginger extract
CAS:<p>Ginger extract demonstrates (exhibits) anti-cancer, anti-inflammatory, and chemotherapeutic properties in living organisms (in vivo).</p>Colore e forma:SolidGliotoxin
CAS:<p>Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.</p>Formula:C13H14N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:326.39NF-κΒ activator 1
CAS:<p>NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns.</p>Formula:C16H11FN2O2SPurezza:99.58%Colore e forma:SolidPeso molecolare:314.33Pratensein
CAS:<p>Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.</p>Formula:C16H12O6Purezza:99.90%Colore e forma:SolidPeso molecolare:300.26PROTAC STING degrader-3
<p>PROTACSTING degrader-3 (Compound ST9) is a STINGPROTAC-type degrader with a DC50 of 0.62 μM. It induces STING degradation via the ubiquitin-proteasome pathway. This compound exerts anti-inflammatory effects by inhibiting the STING/TBK1/NF-κB signaling. Additionally, it offers renal protection and can be used in research on acute kidney injury.</p>Colore e forma:Odour SolidLemnalol
CAS:<p>Lemnalol, from Lemnalia cervicorni, has anti-inflammatory and analgesic properties.</p>Formula:C15H24OPurezza:98%Colore e forma:SolidPeso molecolare:220.35RIPK2-IN-5
CAS:<p>RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.</p>Formula:C21H14N4SPurezza:98.85%Colore e forma:SoildPeso molecolare:354.43Siegesbeckialide I
<p>Siegesbeckialide I effectively suppresses LPS-induced NO production in RAW264.7 murine macrophages by directly interacting with IKKα/β.</p>Formula:C20H28O6Colore e forma:SolidPeso molecolare:364.43Eupenicisirenin C
CAS:Eupenicisirenin C (compound 1), a sirenin derivative, exhibits strong NF-κB inhibitory activities and suppresses the cGAS-STING pathway. Additionally, Eupenicisirenin C inhibits RANKL-induced osteoclast differentiation in bone marrow macrophage cells [1].Formula:C13H18O4Peso molecolare:238.28NF-κB Signaling Compound Library
<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>Colore e forma:Odour SolidMJ210
<p>MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.</p>Colore e forma:Odour SolidPROTAC IRAK4 ligand-4
CAS:<p>PROTAC IRAK4 ligand-4, a Ligand for Target Protein for PROTAC (Ligand for Target Protein for PROTAC), exhibits anti-tumor activity and is utilized in synthesizing PROTAC IRAK4 degrader-12. This compound serves as a targeted ligand with specific applications in the development of cancer therapeutics.</p>Formula:C24H26F2N6O3Colore e forma:SolidPeso molecolare:484.5Anti-osteoporosis agent-8
Anti-osteoporosis agent-8 (Compound 4aa) is a RANKL inhibitor, capable of preventing RANKL-induced osteoclastogenesis and osteoclast differentiation, with an IC50 of 2.41 μM. Furthermore, Anti-osteoporosis agent-8 has been shown to mitigate bone loss in an ovariectomized (OVX) mouse model.Formula:C18H19F3N2O2SePeso molecolare:432.05638R-HP210
<p>R-HP210 blocks LPS-triggered IL-1β, IL-6, COX-2 gene transcription and has a 3.80 μM IC50 for NF-κB inhibition without activating GCs.</p>Formula:C22H19N3O2S2Colore e forma:SolidPeso molecolare:421.54SN50 TFA
<p>SN50 TFA is an inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition. SN50 TFA can be used in studies about ARDS.</p>Formula:C129H230N36O29S·XCF3COOHColore e forma:SolidPeso molecolare:2781.5 (free base)RIPK2/3-IN-1
<p>RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3.</p>Formula:C24H16N4O2S2Purezza:98%Colore e forma:SolidPeso molecolare:456.54IRAK4-IN-8
CAS:<p>IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.</p>Formula:C23H23F2N7O2SPurezza:99.33%Colore e forma:SolidPeso molecolare:499.54IRAK4-IN-10
CAS:<p>IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.</p>Formula:C22H24N8Purezza:98.55%Colore e forma:SolidPeso molecolare:400.48DTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Formula:C26H35N7O5Colore e forma:SolidPeso molecolare:525.6Hesperidin methylchalcone
CAS:Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.Formula:C29H36O15Purezza:99.53%Colore e forma:Yellow PowderPeso molecolare:624.59ML 120B dihydrochloride
CAS:<p>MLN120B dihydrochloride: oral IKKβ inhibitor with 60 nM IC50, suppresses myeloma growth, used in arthritis research.</p>Formula:C19H17Cl3N4O2Colore e forma:SolidPeso molecolare:439.72IRAK inhibitor 2
CAS:<p>IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.</p>Formula:C17H14N4O2Purezza:97.90% - 99.58%Colore e forma:SolidPeso molecolare:306.32Edecesertib
CAS:<p>Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.</p>Formula:C22H22FN7O2Purezza:98.84% - 99.94%Colore e forma:SolidPeso molecolare:435.45RS 09
CAS:<p>TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.</p>Formula:C31H49N9O9Purezza:98%Colore e forma:SolidPeso molecolare:691.78BIZ 114
CAS:<p>BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.</p>Formula:C24H40O3Colore e forma:SolidPeso molecolare:376.57TOMATIDINE HYDROCHLORIDE
CAS:<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Formula:C27H46ClNO2Purezza:99.75% - ≥95%Colore e forma:SolidPeso molecolare:452.11QNZ
CAS:<p>QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.</p>Formula:C22H20N4OPurezza:99.17% - 99.18%Colore e forma:White SolidPeso molecolare:356.42BEC hydrochloride
CAS:<p>BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.</p>Formula:C5H12BNO4S·ClHPurezza:98.65% - 99.28%Colore e forma:SolidPeso molecolare:229.49Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Formula:C20H18O6Purezza:99.81%Colore e forma:Off White PowderPeso molecolare:354.35CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formula:C20H28O3Purezza:97.06% - 99.08%Colore e forma:SolidPeso molecolare:316.43Demethyleneberberine
CAS:<p>Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either</p>Formula:C19H18NO4Purezza:98.08% - 99.18%Colore e forma:SolidPeso molecolare:324.35Morusin
CAS:<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Formula:C25H24O6Purezza:98.68% - 99.8%Colore e forma:SolidPeso molecolare:420.45EUK-134
CAS:EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formula:C18H18ClMnN2O4Purezza:98.39%Colore e forma:SolidPeso molecolare:416.74Flavanomarein
CAS:<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Formula:C21H22O11Purezza:98.63% - 99.54%Colore e forma:SolidPeso molecolare:450.39Neochlorogenic acid
CAS:<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Formula:C16H18O9Purezza:99.12% - 99.54%Colore e forma:White PowderPeso molecolare:354.313'-Sialyllactose
CAS:<p>3'-Sialyllactose (3'-SL), a prebiotic, supports immunity, reduces inflammation and arthritis, and is low-toxicity for research.</p>Formula:C23H39NO19Colore e forma:SolidPeso molecolare:633.55OPHIOPOGONIN D
CAS:<p>Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.</p>Formula:C44H70O16Purezza:99.46% - ≥95%Colore e forma:SolidPeso molecolare:855.02yangonin
CAS:<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Formula:C15H14O4Purezza:98.82% - 99.55%Colore e forma:Pale Yellow PowderPeso molecolare:258.27BI-69A11
CAS:<p>BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.</p>Formula:C25H16ClN3O2Purezza:96.97%Colore e forma:SolidPeso molecolare:425.87SC-514
CAS:<p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>Formula:C9H8N2OS2Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:224.3Iron sucrose
CAS:<p>Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.</p>Formula:C18H24Fe2O24Purezza:99.97%Colore e forma:SolidPeso molecolare:736.1IMM-H007
CAS:<p>IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression</p>Formula:C22H23N5O8Purezza:97.73%Colore e forma:SolidPeso molecolare:485.45Sulfuretin
CAS:<p>Sulfuretin protects HepG2 cells from oxidative damage by scavenging ROS and activating HO-1 via Nrf2/ARE and JNK/ERK pathways.</p>Formula:C15H10O5Purezza:98.91% - 99.86%Colore e forma:SolidPeso molecolare:270.24Flaconitine
CAS:<p>Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.</p>Formula:C36H49NO12Purezza:98% - 99.84%Colore e forma:SolidPeso molecolare:687.77Vanillic Acid
CAS:<p>Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.</p>Formula:C8H8O4Purezza:99.82%Colore e forma:White Odourless Crystals Or PowderPeso molecolare:168.152-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>Formula:C11H10N2OSPurezza:99.48%Colore e forma:SolidPeso molecolare:218.27BOT-64
CAS:<p>BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole</p>Formula:C15H15NO2SPurezza:99.73%Colore e forma:SolidPeso molecolare:273.35
