NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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Ethacrynic acid
CAS:<p>Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。</p>Formula:C13H12Cl2O4Purezza:98.61% - 99.85%Colore e forma:Crystals Physical Description White Solid (Ntp 1992)Peso molecolare:303.14Flaconitine
CAS:<p>Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.</p>Formula:C36H49NO12Purezza:98% - 99.84%Colore e forma:SolidPeso molecolare:687.77Vanillic Acid
CAS:<p>Vanillic Acid (Acide vanillique) is used as a condiment in food, which used in wine. It is an intermediate in the production of vanillin from ferulic acid.</p>Formula:C8H8O4Purezza:99.82%Colore e forma:White Odourless Crystals Or PowderPeso molecolare:168.152-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
CAS:<p>2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.</p>Formula:C11H10N2OSPurezza:99.48%Colore e forma:SolidPeso molecolare:218.27BOT-64
CAS:<p>BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole</p>Formula:C15H15NO2SPurezza:99.73%Colore e forma:SolidPeso molecolare:273.3518α-Glycyrrhetinic acid
CAS:<p>18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.</p>Formula:C30H46O4Purezza:98.54% - 99.68%Colore e forma:SolidPeso molecolare:470.68(E/Z)-IT-603
CAS:<p>(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.</p>Formula:C11H9BrN2O3SPurezza:99.35%Colore e forma:SolidPeso molecolare:329.17MLN120B
CAS:<p>MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).</p>Formula:C19H15ClN4O2Purezza:98.92%Colore e forma:SolidPeso molecolare:366.8Asperulosidic acid
CAS:<p>Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.</p>Formula:C18H24O12Purezza:99.47%Colore e forma:SolidPeso molecolare:432.38BX795
CAS:<p>BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.</p>Formula:C23H26IN7O2SPurezza:98% - 99.57%Colore e forma:SolidPeso molecolare:591.47ISOGINKGETIN
CAS:<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Formula:C32H22O10Purezza:98% - 99.72%Colore e forma:SolidPeso molecolare:566.51PTP1B-IN-1
CAS:PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)Formula:C8H8N2O3SPurezza:99.27%Colore e forma:SolidPeso molecolare:212.23Galloylpaeoniflorin
CAS:<p>Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress.</p>Formula:C30H32O15Purezza:99.82%Colore e forma:SolidPeso molecolare:632.57AZD3264
CAS:<p>AZD3264 is a new type IKK2 inhibitor.</p>Formula:C21H23N5O4SPurezza:98.98% - 99.17%Colore e forma:SolidPeso molecolare:441.5IRAK4-IN-7
CAS:IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.Formula:C21H19N7O3Purezza:99.5%Colore e forma:SolidPeso molecolare:417.42Iron sucrose
CAS:<p>Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.</p>Formula:C18H24Fe2O24Purezza:99.97%Colore e forma:SolidPeso molecolare:736.1yangonin
CAS:<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Formula:C15H14O4Purezza:98.82% - 99.55%Colore e forma:Pale Yellow PowderPeso molecolare:258.27Cyclo(his-pro)
CAS:<p>Cyclo(his-pro) is a cyclic dipeptide that shields against oxidative damage by activating Nrf2.</p>Formula:C11H14N4O2Purezza:99.87%Colore e forma:SolidPeso molecolare:234.25Astaxanthin
CAS:<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>Formula:C40H52O4Purezza:95.1% - 99.79%Colore e forma:Needles From Acetone/Light Petroleum SolidPeso molecolare:596.847,4'-Dihydroxyflavone
CAS:<p>7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti.</p>Formula:C15H10O4Purezza:99.39% - 99.6%Colore e forma:SolidPeso molecolare:254.24Rucaparib
CAS:<p>Rucaparib (PF-01367338) is a orally PARP inhibitor and a H6PD inhibitor. Rucaparib exhibits antitumor activity against CRPC. Cost-effective and quality-assured.</p>Formula:C19H18FN3OPurezza:98.24% - 99.80%Colore e forma:SolidPeso molecolare:323.36GSK8612
CAS:<p>GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .</p>Formula:C17H17BrF3N7O2SPurezza:99.46% - 99.8%Colore e forma:SolidPeso molecolare:520.33Avicularin
CAS:<p>Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.</p>Formula:C20H18O11Purezza:97.02% - 99.94%Colore e forma:White PowderPeso molecolare:434.35Sodium Aescinate
CAS:<p>Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.</p>Formula:C54H83NaO23Purezza:95.17%Colore e forma:SolidPeso molecolare:1123.21Berbamine
CAS:<p>Berbamine is a natural product extracted from Phellodendron amurense.</p>Formula:C37H40N2O6Purezza:98.92% - 99.67%Colore e forma:White Crystal PowderPeso molecolare:608.72Ginsenoside Rb3
CAS:<p>Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.</p>Formula:C53H90O22Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:1079.27Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Formula:C7H4O6Purezza:99.03%Colore e forma:SolidPeso molecolare:184.1Licochalcone D
CAS:<p>Licochalcone D may treat melanoma and heart injury, halt cell spread, and reduce inflammation and allergies.</p>Formula:C21H22O5Purezza:99.03% - 99.9%Colore e forma:SolidPeso molecolare:354.4Muscone
CAS:<p>Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.</p>Formula:C16H30OPurezza:98.97% - ≥98%Colore e forma:Colourless Liquid LiquidPeso molecolare:238.41Eclitasertib
CAS:<p>Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).</p>Formula:C19H18N6O3Purezza:99.85%Colore e forma:SolidPeso molecolare:378.38Specnuezhenide
CAS:<p>Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling.Cost-effective and quality-assured.</p>Formula:C31H42O17Purezza:98% - 99.93%Colore e forma:SolidPeso molecolare:686.66Isoquercetin
CAS:<p>1.</p>Formula:C21H20O12Purezza:98.08% - 99.76%Colore e forma:SolidPeso molecolare:464.38WITHAFERIN A
CAS:<p>WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/</p>Formula:C28H38O6Purezza:97.41% - 99.99%Colore e forma:SolidPeso molecolare:470.6Ginsenoside Rd
CAS:<p>Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.</p>Formula:C48H82O18Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:947.15Dehydroevodiamine
CAS:<p>Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant</p>Formula:C19H15N3OPurezza:99.54%Colore e forma:SolidPeso molecolare:301.34Dauricine
CAS:<p>1.</p>Formula:C38H44N2O6Purezza:99.24% - 99.75%Colore e forma:White PowderPeso molecolare:624.77Dendrophenol
CAS:<p>Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.</p>Formula:C17H20O5Purezza:98.2% - 99.36%Colore e forma:SolidPeso molecolare:304.34Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurezza:98.89% - 99.28%Colore e forma:SolidPeso molecolare:265.25Diethylmaleate
CAS:<p>Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.</p>Formula:C8H12O4Purezza:98%Colore e forma:Colourless LiquidPeso molecolare:172.18SC-514
CAS:<p>SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.</p>Formula:C9H8N2OS2Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:224.3Ac2-26 acetate
<p>Ac2-26 acetate is an active N-terminal peptide of annexin A1(AnxA1).</p>Formula:C141H210N32O44SPurezza:98%Colore e forma:SolidPeso molecolare:3089.43IRAK inhibitor 6
CAS:<p>IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4, IC50: 160 nM).</p>Formula:C20H20N4O3SPurezza:99.44%Colore e forma:SolidPeso molecolare:396.462-Hydroxychalcone
CAS:<p>2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated. It inhibits invasion of breast cancer cells.</p>Formula:C15H12O2Purezza:99.6%Colore e forma:SolidPeso molecolare:224.25Neochlorogenic acid
CAS:<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Formula:C16H18O9Purezza:99.12% - 99.54%Colore e forma:White PowderPeso molecolare:354.31Triacetylresveratrol
CAS:<p>Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.</p>Formula:C20H18O6Purezza:99.81%Colore e forma:Off White PowderPeso molecolare:354.35AS-2444697
CAS:<p>AS-2444697, an IRAK-4 inhibitor (C50=21 nM), offers renal protection via anti-inflammatory effects on human and rat IRAK-4.</p>Formula:C19H21ClN6O4Purezza:97.17%Colore e forma:SolidPeso molecolare:432.862,5-Dihydroxyacetophenone
CAS:<p>2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.</p>Formula:C8H8O3Purezza:99.75%Colore e forma:Yellow PowderPeso molecolare:152.15Phellodendrine
CAS:<p>Phellodendrine may treat nephritis by blocking macrophage and T cell activity in glomeruli.</p>Formula:C20H24NO4Purezza:98.7% - 99.94%Colore e forma:SolidPeso molecolare:342.41Micheliolide
CAS:<p>Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.</p>Formula:C15H20O3Purezza:98% - 99.37%Colore e forma:SolidPeso molecolare:248.32Isovitexin
CAS:<p>1.</p>Formula:C21H20O10Purezza:99.79% - 99.97%Colore e forma:SolidPeso molecolare:432.38
