NF-κB
Il fattore nucleare kappa-light-chain-enhancer delle cellule B attivate (NF-κB) è un fattore di trascrizione che regola l'espressione di geni coinvolti nelle risposte immunitarie, nell'infiammazione, nella sopravvivenza cellulare e nella proliferazione. NF-κB viene attivato in risposta a vari stimoli, tra cui citochine, agenti patogeni e segnali di stress. La disregolazione della segnalazione di NF-κB è associata a malattie infiammatorie croniche, cancro e disturbi autoimmuni. Presso CymitQuimica, offriamo una selezione completa di modulatori della via NF-κB per supportare la tua ricerca su infiammazione, oncologia e regolazione immunitaria.
Trovati 443 prodotti di "NF-κB"
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Robinin
CAS:<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Formula:C33H40O19Purezza:98.78% - 99.13%Colore e forma:SolidPeso molecolare:740.66Engeletin
CAS:<p>1.</p>Formula:C21H22O10Purezza:99.72% - 99.99%Colore e forma:SolidPeso molecolare:434.39Polygalasaponin F
CAS:<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Formula:C53H86O23Purezza:98% - 99.83%Colore e forma:SolidPeso molecolare:1091.24Embelin
CAS:<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Formula:C17H26O4Purezza:97.07% - 99.88%Colore e forma:SolidPeso molecolare:294.39Triptolide
CAS:<p>Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.</p>Formula:C20H24O6Purezza:97.19% - 99.97%Colore e forma:White To Off-White SolidPeso molecolare:360.4Barlerin
CAS:<p>Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injury</p>Formula:C19H28O12Purezza:99.83% - ≥95%Colore e forma:SolidPeso molecolare:448.42TBK1/IKKε-IN-5
CAS:<p>TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).</p>Formula:C28H31N7O3Purezza:98.77%Colore e forma:SolidPeso molecolare:513.59Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Formula:C17H16O4Purezza:99.87% - ≥95%Colore e forma:SolidPeso molecolare:284.31Tyrosol
CAS:<p>Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most</p>Formula:C8H10O2Purezza:99.24% - 99.86%Colore e forma:SolidPeso molecolare:138.16PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.47SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Formula:C10H5ClN4O5SPurezza:99.64%Colore e forma:SolidPeso molecolare:328.69IRAK-1-4 Inhibitor I
CAS:<p>IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.</p>Formula:C20H21N5O4Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:395.41Tomatidine
CAS:<p>Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.</p>Formula:C27H45NO2Purezza:99.94% - 99.98%Colore e forma:SolidPeso molecolare:415.6511-Keto-β-boswellic acid
CAS:11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Formula:C30H46O4Purezza:99.68%Colore e forma:SolidPeso molecolare:470.68RIPA-56
CAS:<p>RIPA-56 is an inhibitor of RIP1</p>Formula:C13H19NO2Purezza:99.53% - 99.93%Colore e forma:SolidPeso molecolare:221.3Zimlovisertib
CAS:<p>Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).</p>Formula:C18H20FN3O4Purezza:98.21%Colore e forma:SolidPeso molecolare:361.37Malachite green oxalate
CAS:<p>Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.</p>Formula:C23H25N2·C2HO4C2H2O4Colore e forma:Dark Green Crystals With A Metallic LusterPeso molecolare:463.51Sarsasapogenin
CAS:<p>Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.</p>Formula:C27H44O3Purezza:90% - 99.73%Colore e forma:White Or Off-Withe PowderPeso molecolare:416.64Obtusifolin
CAS:Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.Formula:C16H12O5Purezza:99.78% - 99.99%Colore e forma:SolidPeso molecolare:284.26Neferine
CAS:<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Formula:C38H44N2O6Purezza:98.81% - 99.65%Colore e forma:SolidPeso molecolare:624.77Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Formula:C21H20O13Purezza:97.57% - 98.97%Colore e forma:SolidPeso molecolare:480.38Aconine
CAS:1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.Formula:C25H41NO9Purezza:99.61% - 99.93%Colore e forma:SolidPeso molecolare:499.59Madecassic acid
CAS:<p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>Formula:C30H48O6Purezza:98.80% - 99.69%Colore e forma:SolidPeso molecolare:504.7Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formula:C21H28BN3O5Purezza:95.52% - 99.46%Colore e forma:SolidPeso molecolare:413.28Deoxyelephantopin
CAS:<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Formula:C19H20O6Purezza:99.6% - 99.71%Colore e forma:SolidPeso molecolare:344.36JH-X-119-01
CAS:<p>JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.</p>Formula:C25H20N6O3Purezza:98.42%Colore e forma:SolidPeso molecolare:452.46Aristolochic acid A
CAS:<p>Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.</p>Formula:C17H11NO7Purezza:99.85% - 99.97%Colore e forma:Yellow PowderPeso molecolare:341.27Indole-3-carbinol
CAS:<p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>Formula:C9H9NOPurezza:98.59% - >99.99%Colore e forma:SolidPeso molecolare:147.17(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Formula:C13H18O2Purezza:99.51% - 99.86%Colore e forma:Colourless Crystalline SolidPeso molecolare:206.28GSK-872
CAS:<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>Formula:C19H17N3O2S2Purezza:99.87% - 99.94%Colore e forma:SolidPeso molecolare:383.493'-Sialyllactose sodium
CAS:3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.Formula:C23H38NNaO19Purezza:>99.99%Colore e forma:SolidPeso molecolare:655.53Gatralimab
CAS:<p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion & repopulation in Phase 1, supporting its study for relapsing MS.</p>Purezza:95%Colore e forma:Liquid1,3-Dibenzyl-5-fluorouracil
CAS:<p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>Formula:C18H15FN2O2Colore e forma:SolidPeso molecolare:310.32Kamebakaurin
CAS:<p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>Formula:C20H30O5Purezza:98.05%Colore e forma:SolidPeso molecolare:350.45E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formula:C21H30O6Purezza:99.52%Colore e forma:SolidPeso molecolare:378.46IMD-catechol
CAS:<p>IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.</p>Formula:C31H34N6O3Purezza:98%Colore e forma:SolidPeso molecolare:538.64PHA-408
CAS:<p>PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.</p>Formula:C29H27ClFN7O2Purezza:98%Colore e forma:SolidPeso molecolare:560.02AP-1/NF-κB activation inhibitor 1
CAS:<p>AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal</p>Formula:C13H11F3N4O4Purezza:99.52% - 99.91%Colore e forma:SolidPeso molecolare:344.25TBK1/IKKε-IN-4
CAS:<p>TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM</p>Formula:C28H35N7O4Colore e forma:SolidPeso molecolare:533.62NF-κB-IN-3
CAS:<p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>Formula:C24H18ClF3N2O2Colore e forma:SolidPeso molecolare:458.86HSR1304
CAS:<p>HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.</p>Formula:C24H21ClN2O3Colore e forma:SolidPeso molecolare:420.89ABD-350
CAS:<p>ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.</p>Formula:C19H22F2O2Colore e forma:SolidPeso molecolare:320.37MHY884
CAS:<p>MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.</p>Formula:C15H14ClNO3SPurezza:98%Colore e forma:SolidPeso molecolare:323.79IT-901
CAS:<p>IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.</p>Formula:C17H14N2O4SPurezza:98.06%Colore e forma:SolidPeso molecolare:342.37Asperbisabolane L
<p>Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.</p>Formula:C12H14O3Colore e forma:SolidPeso molecolare:206.24CID-2858522
CAS:<p>CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).</p>Formula:C28H39N3O3Purezza:96.12%Colore e forma:SolidPeso molecolare:465.63IMD-biphenylB
CAS:<p>IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.</p>Formula:C35H33N5O3Purezza:98%Colore e forma:SolidPeso molecolare:571.671-Dehydro-[10]-gingerdione
CAS:<p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>Formula:C21H30O4Colore e forma:SolidPeso molecolare:346.46Bay 65-1942 free base
CAS:Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.Formula:C22H25N3O4Purezza:98%Colore e forma:SolidPeso molecolare:395.45TRAF-STOP inhibitor 6877002
CAS:<p>TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.</p>Formula:C17H17NOPurezza:99.76%Colore e forma:SolidPeso molecolare:251.32
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