Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 79 prodotti di "Nrf2"
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TAT 14
CAS:<p>TAT 14: a 14-mer peptide Nrf2 activator, anti-inflammatory, boosts Nrf2 protein, targets Keap1, no effect on mRNA.</p>Formula:C137H230N48O39Purezza:98%Colore e forma:SolidPeso molecolare:3173.59S217879
<p>S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway.</p>Formula:C29H30N4O7SColore e forma:SolidPeso molecolare:578.64Keap1-Nrf2-IN-9
CAS:<p>Keap1-Nrf2-IN-9 inhibits Keap1-Nrf2 PPI with 0.575 µM IC50, boosts Nrf2 genes, non-toxic in ARPE19 cells.</p>Formula:C31H30N2O11S2Colore e forma:SolidPeso molecolare:670.71Deacetylgedunin
CAS:<p>Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.</p>Formula:C26H32O6Colore e forma:SolidPeso molecolare:440.53Anticonvulsant agent 10
<p>Anticonvulsant agent 10 (Compound 6d) is an inhibitor targeting the Keap1-Nrf2 interaction, with a strong activity showing an ED50 of 0.04 mmol/kg. By inhibiting the Keap1-Nrf2 binding, it activates the Nrf2/ARE pathway, providing anticonvulsant and neuroprotective effects, making it useful for research in epilepsy and neuroprotection.</p>Colore e forma:Odour SolidKeap1-IN-1
<p>Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.</p>Formula:C17H21Cl2N2O5PS3Colore e forma:SolidPeso molecolare:531.434Keap1-Nrf2-IN-3
CAS:<p>Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.</p>Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.652Keap1-Nrf2-IN-27
<p>Keap1-Nrf2-IN-27 is an inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with a KD2 value of 0.119 μM. It suppresses the expression of pro-inflammatory cytokines TNF-α and IL-6 in an LPS-induced RAW264.7 cell model.</p>Colore e forma:Odour SolidMonascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formula:C21H26O5Purezza:98%Colore e forma:SolidPeso molecolare:358.43CBR-470-2
CAS:<p>CBR-470-2 activates NRF2 signaling, aiding in glycolysis research.</p>Formula:C12H13Cl2NO6S2Colore e forma:SolidPeso molecolare:402.26ML334
CAS:<p>ML334 (LH601A) is an NRF2 activator that inhibits cardiac fibroblast activation and proliferation ameliorating myocardial infarction-induced cardiac fibrosis.</p>Formula:C26H26N2O5Purezza:98.06% - 98.06%Colore e forma:SolidPeso molecolare:446.49I-152
CAS:<p>Bepranemab (UCB 0107) is a humanized IgG monoclonal antibody against tau for the study of Alzheimer's disease (AD) and tau proteinopathies.</p>Formula:C9H16N2O3S2Purezza:98.36%Colore e forma:SolidPeso molecolare:264.37Anti-NFE2L2 Antibody (9K94)
<p>Anti-NFE2L2 Antibody (9K94) is a Mouse antibody targeting NFE2L2. Anti-NFE2L2 Antibody (9K94) can be used in ELISA, WB, IHC, IF, FCM.</p>Purezza:>95%Colore e forma:Odour LiquidAnti-Phospho-NFE2L2 (Ser40) Antibody (6V851)
<p>Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) is an antibody targeting Phospho-NFE2L2 (Ser40). Anti-Phospho-NFE2L2 (Ser40) Antibody (6V851) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidAnti-NFE2L2 Antibody (6K859)
<p>Anti-NFE2L2 Antibody (6K859) is an antibody targeting NFE2L2. Anti-NFE2L2 Antibody (6K859) can be used in ELISA, IF.</p>Colore e forma:Odour LiquidDimethyl fumarate-d6
CAS:<p>Dimethyl fumarate D6 is a deuterium labeled Dimethyl fumarate. can induces upregulation of antioxidant gene expression.</p>Formula:C6H8O4Purezza:98%Colore e forma:SolidPeso molecolare:150.16KI696 isomer
CAS:<p>KI696 isomer is an isomer of KI696, a low affinity probe for the study of immune and metabolic diseases.</p>Formula:C28H30N4O6SPurezza:99.8%Colore e forma:SolidPeso molecolare:550.63Brusatol
CAS:<p>Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.</p>Formula:C26H32O11Purezza:99.35% - 99.95%Colore e forma:SolidPeso molecolare:520.53Trilobatin
CAS:<p>Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially</p>Formula:C21H24O10Purezza:97.16%Colore e forma:SolidPeso molecolare:436.41AEM1
CAS:<p>AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.</p>Formula:C20H14FN3O2SPurezza:98.37% - 99.88%Colore e forma:SolidPeso molecolare:379.41
