Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 84 prodotti per "Nrf2".
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BPK-29
CAS:BPK-29 disrupts NR0B1 binding and modifies C274, inhibiting growth in KEAP1-mutant cancers.Formula:C26H32ClN3O3Purezza:98%Colore e forma:SolidPeso molecolare:470AI-3
CAS:Nrf2/Keap1 and Keap1/Cul3 interaction inhibitorFormula:C11H13ClO3S2Purezza:98%Colore e forma:SolidPeso molecolare:292.8WN1316
CAS:WN1316 is a unique neuroprotectant against oxidative injury, being a highly promising remedy for the treatment of amyotrophic lateral sclerosis (ALS).Formula:C20H26Cl3N5OColore e forma:SolidPeso molecolare:458.81Dihydrolipoic acid
CAS:Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.Formula:C8H16O2S2Purezza:97.51%Colore e forma:Yellow To Orange LiquidPeso molecolare:208.34K67
CAS:K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.Formula:C29H30N2O7S2Purezza:98.43%Colore e forma:Yellow SolidPeso molecolare:582.688DDO-7263
CAS:DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.Formula:C14H9F2N3OPurezza:99.85%Colore e forma:White SolidPeso molecolare:273.2376Nrf2 activator-7
CAS:Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.Formula:C35H32N2O11S2Colore e forma:SolidPeso molecolare:720.77Nrf2-IN-1
CAS:Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Formula:C21H22ClN3O2Purezza:95.00% - 99.68%Colore e forma:SolidPeso molecolare:383.871WRR139
CAS:WRR139 is an NGLY1 inhibitor that impairs Nrf1 processing and sensitizes cancer cells to proteasome inhibitors.Formula:C25H32N2O4SPurezza:99.90%Colore e forma:White SolidPeso molecolare:456.6Keap1-Nrf2-IN-16
CAS:Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.Formula:C73H114N16O26Colore e forma:SolidPeso molecolare:1631.78Keap1-Nrf2-IN-15
CAS:Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescenceFormula:C39H35N3O12S2Colore e forma:SolidPeso molecolare:801.84Keap1-IN-1
Keap1-IN-1 (Compound 27) is an inhibitor of Keap1, functioning by covalently modifying the Cys151 residue on the BTB domain of KEAP1, thereby disrupting the interaction between Keap and Nrf. It enhances the mRNA expression of the antioxidant response element (ARE) dependent gene NQO1, with an EC50 of 160 nM, and exhibits cytotoxicity in U2OS cells, with an EC50 of 527 nM.Formula:C17H21Cl2N2O5PS3Colore e forma:SolidPeso molecolare:531.434Nrf2-IN-3
CAS:Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.Formula:C22H26N4O4SPurezza:97.75%Colore e forma:SolidPeso molecolare:442.53Nrf2 degrader 1
CAS:Nrf2 degrader 1 is a PROTAC degrading Nrf2, inhibiting A549 and LK-2 cells (IC₅₀ = 100 nM and 40 nM).Formula:C45H42N6O8SColore e forma:SolidPeso molecolare:826.92CPDT
CAS:CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.Formula:C6H6S3Colore e forma:SolidPeso molecolare:174.307Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Formula:C20H17BrO3Colore e forma:SolidPeso molecolare:385.25Keap1-Nrf2-IN-3
CAS:Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.Formula:C31H34N6O3Colore e forma:SolidPeso molecolare:538.652Keap1-Nrf2-IN-5
CAS:Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).Formula:C23H30N4O6SColore e forma:SolidPeso molecolare:490.57NFE2L2 activator 3
CAS:NFE2L2 activator 3 (Compound 3) is an activator of NFE2L2/NRF2, specifically enhancing the activity of NAD(P)H:quinone oxidoreductase (NQO1), with an EC50 of less than 1 nM. It is useful for researching respiratory diseases such as chronic obstructive pulmonary disease.Formula:C29H33ClN4O5S2Peso molecolare:617.18CYP2E1-IN-1
CAS:CYP2E1-IN-1 (Compound 10) is an orally active inhibitor of cytochrome P450 2E1 (CYP2E1) with a dissociation constant (Kd) of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. It alleviates pancreatic damage by activating the Nrf2/HO-1 signaling pathway and inhibiting ROS production. CYP2E1-IN-1 demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing inflammation and oxidative stress in severe acute pancreatitis (SAP). It is suitable for the study of SAP and other inflammation-related conditions.Formula:C6H7NOSPeso molecolare:141.191
