Nrf2
Nrf2 è un fattore di trascrizione che regola l'espressione di proteine antiossidanti ed enzimi di detossificazione, svolgendo un ruolo fondamentale nella difesa cellulare contro lo stress ossidativo e l'infiammazione. L'attivazione della segnalazione Nrf2 fornisce protezione contro varie malattie, tra cui il cancro, la neurodegenerazione e i disturbi cardiovascolari. I modulatori di Nrf2 sono oggetto di studio per le loro potenziali applicazioni terapeutiche nella riduzione dei danni ossidativi e dell'infiammazione. Presso CymitQuimica, offriamo una gamma di modulatori della via Nrf2 di alta qualità per supportare la tua ricerca sullo stress ossidativo, l'infiammazione e la prevenzione delle malattie.
Trovati 78 prodotti di "Nrf2"
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CAS:<p>Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor</p>Formula:C11H13ClO3S2Purezza:98%Colore e forma:SolidPeso molecolare:292.8Nrf2 activator-4
CAS:<p>Nrf2 activator-4 is an Nrf2 activator for the treatment of fatty liver disease associated with metabolic dysfunction in humans.</p>Formula:C23H24ClF3N2O3Purezza:98.53%Colore e forma:SolidPeso molecolare:468.9K67
CAS:<p>K67 competitively inhibits the interaction between Nrf2-ETGE and Keap1 and can be used to study cancer.</p>Formula:C29H30N2O7S2Purezza:98.43%Colore e forma:SolidPeso molecolare:582.69DDO-7263
CAS:<p>DDO-7263, a 1,2,4-Oxadiazole, boosts Nrf2 by binding Rpn6, blocking 26S proteasome assembly, and has anti-inflammatory effects.</p>Formula:C14H9F2N3OPurezza:99.85%Colore e forma:SolidPeso molecolare:273.24CDDO-EA
CAS:<p>CDDO-EA (CDDO ethyl amide) is an activator of the Nrf2/antioxidant response element.</p>Formula:C33H46N2O3Purezza:99.66%Colore e forma:SolidPeso molecolare:518.73Keap1-Nrf2-IN-15
CAS:<p>Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence</p>Formula:C39H35N3O12S2Colore e forma:SolidPeso molecolare:801.84Keap1-Nrf2-IN-16
CAS:<p>Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.</p>Formula:C73H114N16O26Colore e forma:SolidPeso molecolare:1631.78Keap1-Nrf2-IN-6
<p>Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM</p>Formula:C30H34N4O8SColore e forma:SolidPeso molecolare:610.68Nrf2-IN-1
CAS:<p>Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).</p>Formula:C21H22ClN3O2Purezza:95.00% - 99.68%Colore e forma:SolidPeso molecolare:383.87Nrf2 activator-7
CAS:<p>Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.</p>Formula:C35H32N2O11S2Colore e forma:SolidPeso molecolare:720.77Nrf2-IN-3
CAS:<p>Nrf2-IN-3 is an NRF2 inhibitor that selectively sensitizes xenografts of mouse mKEAP1 cancer cells to cisplatin.</p>Formula:C22H26N4O4SPurezza:98.07%Colore e forma:SolidPeso molecolare:442.53CPDT
CAS:<p>CPDT is an orally active and potent inducer of phase 2 enzymes as well as an activator of Nrf2. CPDT enhances the activity of critical phase 2 enzymes, such as glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and gamma-glutamylcysteine synthetase, and increases glutathione levels both in the bladder of rats and in bladder cells in vitro.</p>Formula:C6H6S3Colore e forma:SolidPeso molecolare:174.307Nrf2 activator-2
<p>Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.</p>Formula:C20H17BrO3Colore e forma:SolidPeso molecolare:385.25Nrf2 activator-6
CAS:<p>Nrf2 activator-6, a tetrahydroisoquinoline, inhibits Kelch-Nrf2 at 5 nM IC50 (WO2021214470A1).</p>Formula:C31H37ClFN5O5Colore e forma:SolidPeso molecolare:614.11Keap1-Nrf2-IN-5
CAS:<p>Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).</p>Formula:C23H30N4O6SColore e forma:SolidPeso molecolare:490.57VVD-130037
CAS:<p>VVD-130037 is a KEAP1 activator with potential antitumor activity.VVD-130037 inhibits tumor growth in advanced solid tumors by degrading NRF2.</p>Formula:C17H17ClN4O2Purezza:99.01% - 99.92%Colore e forma:SolidPeso molecolare:344.8KI696
CAS:<p>KI696 is a high-affinity probe that potently inhibits the interaction of Keap1 and NRF2.</p>Formula:C28H30N4O6SPurezza:99.74%Colore e forma:SolidPeso molecolare:550.63NSC23925
CAS:NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).Formula:C22H26Cl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:421.36
