CXCR
I CXCR sono una sottoclasse di GPCR che si legano alle chemochine, piccole proteine segnale che guidano il movimento delle cellule immunitarie verso i siti di infiammazione, infezione o lesione. I CXCR svolgono ruoli cruciali nelle risposte immunitarie, nella metastasi del cancro e nelle malattie infiammatorie. I modulatori dei CXCR sono studiati per il loro potenziale nel trattamento delle malattie autoimmuni, del cancro e delle condizioni infiammatorie croniche. Presso CymitQuimica, offriamo una gamma di modulatori di CXCR di alta qualità per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 155 prodotti di "CXCR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
HF50731
CAS:HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).Formula:C26H46N4Colore e forma:SolidPeso molecolare:414.67ICT5040
CAS:ICT5040 is a CXCR4 antagonist.Formula:C10H8F3N3OSColore e forma:SolidPeso molecolare:275.25SB-332235
CAS:SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.Formula:C13H10Cl3N3O4SColore e forma:SolidPeso molecolare:410.66VUF11211
CAS:VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.Formula:C26H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:504.49TN-14003
CAS:TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Formula:C90H141N33O18S2Colore e forma:SolidPeso molecolare:2037.42CXCR4 antagonist 8
CAS:CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.Formula:C21H26N6Colore e forma:SolidPeso molecolare:362.47HF51116
CAS:HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Formula:C29H46N8OColore e forma:SolidPeso molecolare:522.73SX-517
CAS:SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Formula:C19H16BFN2O3SColore e forma:SolidPeso molecolare:382.22KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Formula:C32H37N7O2Colore e forma:SolidPeso molecolare:551.68IT1t
CAS:IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Formula:C21H34N4S2Purezza:98%Colore e forma:SolidPeso molecolare:406.65VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Formula:C31H41N5O2Purezza:98%Colore e forma:SolidPeso molecolare:515.69GSK812397
CAS:GSK812397 inhibits X4-tropic HIV-1 with high potency, targeting CXCR4 receptor noncompetitively and showing broad efficacy and good pharmacokinetics.Formula:C24H32N6OColore e forma:SolidPeso molecolare:420.55Burixafor hydrobromide
CAS:<p>Burixafor hydrobromide is an oral CXCR4 blocker with anti-angiogenic properties, potentially treating choroid neovascularization.</p>Formula:C27H52BrN8O3PPurezza:98%Colore e forma:SolidPeso molecolare:647.644SRT3190
CAS:SRT3190 is an antagonist of CXCR2.Formula:C18H23F2N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:475.53Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Formula:C17H17Cl2FN4O4SPurezza:98.65% - 99.78%Colore e forma:SolidPeso molecolare:463.31IT1t dihydrochloride
CAS:<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Formula:C21H36Cl2N4S2Purezza:99.91%Colore e forma:SolidPeso molecolare:479.57NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurezza:97.08%Colore e forma:SolidPeso molecolare:395.54Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Formula:C21H27N5Purezza:98.56%Colore e forma:SolidPeso molecolare:349.47AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Formula:C19H25N5OS2Purezza:98.73% - 99.68%Colore e forma:SolidPeso molecolare:403.56AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Formula:C15H14F2N4O2S2Purezza:98.35% - 99.67%Colore e forma:SolidPeso molecolare:384.42
