CXCR
I CXCR sono una sottoclasse di GPCR che si legano alle chemochine, piccole proteine segnale che guidano il movimento delle cellule immunitarie verso i siti di infiammazione, infezione o lesione. I CXCR svolgono ruoli cruciali nelle risposte immunitarie, nella metastasi del cancro e nelle malattie infiammatorie. I modulatori dei CXCR sono studiati per il loro potenziale nel trattamento delle malattie autoimmuni, del cancro e delle condizioni infiammatorie croniche. Presso CymitQuimica, offriamo una gamma di modulatori di CXCR di alta qualità per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 155 prodotti di "CXCR"
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TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formula:C23H32N4Purezza:98%Colore e forma:SolidPeso molecolare:364.53NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:468.46Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formula:C11H12F3NNaO6S2Colore e forma:SolidPeso molecolare:398.32CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.Formula:C21H30N6Colore e forma:SolidPeso molecolare:366.5CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColore e forma:SolidPeso molecolare:362.38AZD0233
CAS:AZD0233 is an orally-active CX3CR1 antagonist. AZD0233 can regulate the CX3CR1/CX3CL1 signaling axis, and has excellent physicochemical properties, metabolic stability, low toxicity and CYP inhibitory characteristics.Formula:C19H29FN6O4SPeso molecolare:456.54CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formula:C15H17N5O3Colore e forma:SolidPeso molecolare:315.33CXCR2-IN-2
CAS:CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Formula:C60H80N14O14Purezza:98%Colore e forma:SolidPeso molecolare:1221.36CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formula:C17H17FN2O4SColore e forma:SolidPeso molecolare:364.39(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:603.59E6130
CAS:E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.Formula:C28H37ClF3N3O3Colore e forma:SolidPeso molecolare:556.06AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formula:C34H58Br8N8Colore e forma:SolidPeso molecolare:1218.13AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formula:C34H50N8Colore e forma:SolidPeso molecolare:570.81CXCR2-IN-1
CAS:<p>CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.</p>Formula:C19H20Cl2FN3O4SPurezza:99.89%Colore e forma:SolidPeso molecolare:476.35CXCR2 antagonist 5
<p>CXCR2 antagonist 5 (compound 25) binds strongly (IC50=0.013μM) and mobilizes calcium (IC50=0.1μM).</p>Formula:C15H14F2N4O2SColore e forma:SolidPeso molecolare:352.36ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formula:C25H25F3N10O2SColore e forma:SolidPeso molecolare:586.59Paeoniflorin-6′-O-benzene sulfonate
CAS:Paeoniflorin-6′-O-benzene sulfonate (CP-25) acts as an inhibitor of G protein-coupled receptor kinase 2 (GRK2), preventing its translocation to the cell membrane and inhibiting the JAK1/STAT3 signaling pathway. It suppresses HaCaT cell proliferation induced by IL-17A/CXCL2. In mouse models, CP-25 reduces the levels of inflammatory cytokines and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3, and CXCL9, thereby alleviating psoriasis induced by Imiquimod.Formula:C29H32O13SColore e forma:SolidPeso molecolare:620.622EMU-116
CAS:EMU-116 is an orally active antagonist of CXCR4, utilized in cancer research.Formula:C25H35N5Colore e forma:SolidPeso molecolare:405.58
