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TLR

TLR

I recettori Toll-like (TLR) sono una classe di proteine che svolgono un ruolo fondamentale nel sistema immunitario innato riconoscendo i pattern molecolari associati ai patogeni (PAMP) e iniziando risposte immunitarie. I TLR sono coinvolti nel rilevamento di un'ampia gamma di patogeni, tra cui batteri, virus e funghi, e sono essenziali per l'attivazione delle vie di segnalazione infiammatorie. La disregolazione della segnalazione dei TLR è associata a malattie infiammatorie croniche, disturbi autoimmuni e cancro. Presso CymitQuimica, offriamo una varietà di modulatori TLR di alta qualità per supportare la tua ricerca sull'immunità innata, l'infiammazione e le malattie infettive.

Trovati 76 prodotti di "TLR"

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  • TLR7/8-IN-1
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    TLR7/8-IN-1

    CAS:
    <p>TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research.Cost-effective and quality-assured.</p>
    Formula:C29H40N8O2
    Purezza:99.83%
    Colore e forma:Solid
    Peso molecolare:532.68

    Ref: TM-T38078

  • Rabeximod
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    Rabeximod

    CAS:
    <p>Rabeximod, an immunomodulator, eases autoimmune diseases, inhibits arthritis, and aids brain recovery post-injury by blocking inflammation.</p>
    Formula:C22H24ClN5O
    Purezza:99.99%
    Colore e forma:Solid
    Peso molecolare:409.91

    Ref: TM-T34249

  • BBIQ
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    BBIQ

    CAS:
    BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1
    Formula:C21H22N4
    Purezza:99.71%
    Colore e forma:Solid
    Peso molecolare:330.43

    Ref: TM-T14513

  • M62812
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    M62812

    CAS:
    TLR4 inhibitor blocks LPS-induced NF-κB (IC50=2.4μg/mL), cytokines in PBMCs/HUVECs, and extends life in septic shock mice.
    Formula:C13H13Cl2N3OS
    Purezza:99.07%
    Colore e forma:Solid
    Peso molecolare:330.23

    Ref: TM-T37292

  • SM360320
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    SM360320

    CAS:
    <p>SM360320 (CL-087) is a selective TLR7 agonist that blocks HCV replication in hepatocytes and aids immunology research.</p>
    Formula:C15H17N5O3
    Purezza:99.13%
    Colore e forma:Solid
    Peso molecolare:315.33

    Ref: TM-T19675

  • Logo CymitQuimica
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    1Z105

    CAS:
    1Z105, an orally active TLR4/MD2 ligand, facilitates dendritic cell maturation and antigen presentation, thereby preventing arthritis.
    Formula:C25H26N4O2S
    Peso molecolare:446.57

    Ref: TM-T200347

  • TLR7 agonist 23
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    TLR7 agonist 23

    CAS:
    <p>TLR7 agonist23 (compound 12b) is a potent agonist of Toll-like receptor-7 (TLR7), with an EC50 value of 0.15 uM. It is suitable for research in immune diseases.</p>
    Formula:C21H22N4O2
    Colore e forma:Solid
    Peso molecolare:362.42

    Ref: TM-T88779

  • TLR9-IN-1
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    TLR9-IN-1

    CAS:
    <p>TLR9-IN-1: selective, potent human TLR9 inhibitor (IC50: 7 nM), useful for researching immune-related diseases.</p>
    Formula:C23H31N7O
    Colore e forma:Solid
    Peso molecolare:421.54

    Ref: TM-T62254

  • CU-CPD107
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    CU-CPD107

    CAS:
    <p>CU-CPD107 selectively activates TLR8 and ssRNA, inhibits TLR8 with R848 (IC50=13.7 μM), and coactivates with ssRNA.</p>
    Formula:C16H21IN2O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:400.25

    Ref: TM-T35349

  • ABR-238901
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    ABR-238901

    CAS:
    ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products
    Formula:C11H9BrClN3O4S
    Purezza:98.63% - 98.71%
    Colore e forma:Solid
    Peso molecolare:394.63

    Ref: TM-T39115

  • SARM1-IN-4
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    SARM1-IN-4

    CAS:
    SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor that reduces plasma neurofilament light chain (NfL) levels in a mouse model following a 50 mg/kg oral dose. By inhibiting the NAD+ hydrolase activity of SARM1, it prevents programmed axon degeneration, making it useful for research in neurodegenerative and neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathy.
    Formula:C13H17F2N3O2
    Colore e forma:Solid
    Peso molecolare:285.29

    Ref: TM-T206825

  • SARM1-IN-5
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    SARM1-IN-5

    CAS:
    SARM1-IN-5 (compound 1-23-a) is an inhibitor of SARM1, useful for researching diseases related to axonal degeneration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
    Formula:C18H17FN6O
    Colore e forma:Solid
    Peso molecolare:352.37

    Ref: TM-T207193

  • TLR7 agonist 28
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    TLR7 agonist 28

    CAS:
    TLR7 agonist28 (compound 3) is a potent TLR7 agonist. This compound can be combined with anti-tumor monoclonal antibodies (mAb) for use in cancer immunotherapy.
    Formula:C26H25N9O7
    Colore e forma:Solid
    Peso molecolare:575.533

    Ref: TM-T204940

  • Creatine ethyl ester
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    Creatine ethyl ester

    CAS:
    Creatine ethyl ester (CEE) is a readily available form of creatine commonly used in supplements. It can upregulate TLRs (TLR2, 3, 4, and TLR7) over a short period.
    Formula:C6H13N3O2
    Colore e forma:Solid
    Peso molecolare:159.186

    Ref: TM-T206807

  • LHC-165
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    LHC-165

    CAS:
    LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
    Formula:C29H32F2N3O7P
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:603.55

    Ref: TM-T15751

  • TLR7/8/9 antagonist 2
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    TLR7/8/9 antagonist 2

    CAS:
    <p>TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.</p>
    Formula:C23H31N7
    Purezza:98%
    Colore e forma:Soild
    Peso molecolare:405.54

    Ref: TM-T72035

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