Segnalazione JAK/STAT
Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.
Sottocategorie di "Segnalazione JAK/STAT"
Trovati 345 prodotti di "Segnalazione JAK/STAT"
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JAK2 Inhibitor V
CAS:JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.Formula:C23H24N2OPurezza:98.36% - 99.15%Colore e forma:SolidPeso molecolare:344.45Ref: TM-T3042
2mg37,00€5mg54,00€10mg80,00€25mg148,00€50mg259,00€100mg477,00€500mg1.063,00€1mL*10mM (DMSO)59,00€Golidocitinib
CAS:Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM).Formula:C25H31N9O2Purezza:98.87% - 99.88%Colore e forma:SolidPeso molecolare:489.57Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formula:C25H26F2N6O2Purezza:99.58%Colore e forma:SoildPeso molecolare:480.51Ref: TM-T67907
1mg96,00€2mg139,00€5mg227,00€10mg354,00€25mg653,00€50mg938,00€100mg1.454,00€500mg2.822,00€KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Formula:C60H74ClN10O14PSPurezza:98.12%Colore e forma:SolidPeso molecolare:1257.78Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Formula:C16H18N6OPurezza:99.95%Colore e forma:SolidPeso molecolare:310.35Ref: TM-T15096
1mg169,00€5mg311,00€10mg487,00€25mg929,00€50mg1.415,00€100mg2.062,00€200mg2.775,00€1mL*10mM (DMSO)349,00€WDR5-IN-6
CAS:WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6Formula:C13H8Cl2N2O2SPurezza:99.69%Colore e forma:SoildPeso molecolare:327.19Gusacitinib
CAS:Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).Formula:C24H28N8O2Purezza:98.06% - 99.94%Colore e forma:SolidPeso molecolare:460.53Ref: TM-T14331
1mg42,00€5mg88,00€10mg123,00€25mg188,00€50mg350,00€100mg522,00€200mg750,00€1mL*10mM (DMSO)116,00€Brepocitinib P-Tosylate
CAS:<p>Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).</p>Formula:C25H29F2N7O4SPurezza:99.82% - 99.97%Colore e forma:SolidPeso molecolare:561.6Uzansertib phosphate
CAS:Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase, inhibiting PIM1, PIM2 and PIM3.Formula:C26H29F3N5O7PPurezza:99.75% - 99.79%Colore e forma:SolidPeso molecolare:611.51Ilginatinib hydrochloride
CAS:Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C21H21ClFN7Purezza:99.55%Colore e forma:SolidPeso molecolare:425.89Ref: TM-T12266L2
1mg70,00€5mg150,00€10mg215,00€25mg358,00€50mg517,00€100mg707,00€200mg973,00€1mL*10mM (DMSO)166,00€Bromisoval
CAS:Bromisoval (Isobromyl) is a mild hypnotic and sedative with potential toxicity.Formula:C6H11BrN2O2Purezza:98.86%Colore e forma:SolidPeso molecolare:223.07Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Formula:C21H20FN7Purezza:98.4% - 99.01%Colore e forma:SolidPeso molecolare:389.43Ref: TM-T12266
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)133,00€Ilginatinib maleate
CAS:<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Formula:C25H24FN7O4Purezza:99.74% - 99.82%Colore e forma:SolidPeso molecolare:505.5Pim-1 kinase inhibitor 8
CAS:Pim-1 kinase inhibitor 8 is a Pim-1 kinase inhibitor with anticancer activity that inhibits cell migration and can be studied in breast cancer.Formula:C14H17N3O3Purezza:99.81%Colore e forma:SoildPeso molecolare:275.3N-(3-Aminopropyl)cyclohexylamine
CAS:N-(3-Aminopropyl)cyclohexylamine inhibits spermine synthase; used in neuro disease research.Formula:C9H20N2Purezza:98.05% - 98.82%Colore e forma:Pale Yellow Clear LiquidPeso molecolare:156.2685KT-333 ammonium
CAS:KT-333 ammonium (Compound A) acts as a molecular glue that targets and promotes the degradation of the STAT3 protein through the ubiquitin-proteasome system. This compound achieves selective degradation by binding simultaneously to the STAT3 protein and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). It exhibits strong selectivity and efficacy in degrading STAT3, possessing notable antitumor properties. KT-333 ammonium is particularly useful for research on hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].Formula:C60H77ClN11O14PSColore e forma:SolidPeso molecolare:1274.81JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Purezza:98%Colore e forma:Odour SolidAxltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Formula:C63H107N19O20S2Purezza:98%Colore e forma:SolidPeso molecolare:1514.77KT-333 diammonium
CAS:KT-333 diammonium functions as a molecular glue that targets and degrades the STAT3 protein. It selectively mediates the degradation of STAT3 via the ubiquitin-proteasome pathway by attaching to STAT3 and the E3 ubiquitin ligase von Hippel-Lindau protein (VHL). This compound exhibits strong specificity in degrading STAT3 and demonstrates significant antitumor activity. KT-333 diammonium is applicable in researching hematologic malignancies, including large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL).Formula:C60H80ClN12O14PSColore e forma:SolidPeso molecolare:1291.84JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formula:C14H10ClN3OS2Purezza:99.64%Colore e forma:SolidPeso molecolare:335.83SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFormula:C43H45N13O9SPurezza:98%Colore e forma:SolidPeso molecolare:919.96STAT4-IN-1
STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.Colore e forma:Odour SolidAc-GpYLPQTV-NH2 acetate
Ac-GpYLPQTV-NH2 acetate is a STAT3 inhibitor with an IC50 value of 0.33 μM. It also exhibits antitumor properties.Formula:C38H60N9O14P·xC2H4O2Colore e forma:SolidPeso molecolare:897.91 (free base)JAK1/TYK2-IN-1
CAS:JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Formula:C18H20F3N7OColore e forma:SolidPeso molecolare:407.401LH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Formula:C29H31F3N6O2SColore e forma:SolidPeso molecolare:584.66Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formula:C16H16ClN5O2Colore e forma:SolidPeso molecolare:345.78SD-2301
CAS:SD-2301 is a PROTAC degrader of STAT3.Formula:C64H80N13O15PS2Colore e forma:SolidPeso molecolare:1366.50JAK-IN-29
JAK-IN-29 (Compound 3) is a potent inhibitor of Janus kinases (JAK) [1].Formula:C17H14ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:355.78HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Formula:C60H69N17O11SColore e forma:SolidPeso molecolare:1236.36STAT3 degrader-1
CAS:STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].Formula:C58H63F5N9O12PSColore e forma:SolidPeso molecolare:1236.2OICR41114
OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand, Dimethyl-F-OICR-9429-COOH, an E3 ligase ligand, OICR-8268-acrylic acid, and a PROTAC linker, Amino-PEG9-amine. Notably, the conjugate of the E3 ligase ligand and the linker is OICR-8268-acrylic acid-amino-PEG9-amine.Formula:C70H83Cl2F6N9O15Colore e forma:SolidPeso molecolare:1475.36Pim-1 kinase inhibitor 11
<p>Pim-1 kinase inhibitor 11 (10f) is an inhibitor of PIM-1 with an IC50 value of 0.18 μM. It exhibits anticancer activity by inducing apoptosis and causing cell cycle arrest.</p>Colore e forma:Odour SolidPROTAC STAT3 degrader-3
PROTACSTAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anti-cancer properties.Formula:C33H29F5N6O9SPeso molecolare:780.16369STAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formula:C36H61N8O12PColore e forma:SolidPeso molecolare:828.89JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formula:C30H32N8O5SColore e forma:SolidPeso molecolare:616.69R8-T198wt
CAS:Cell-permeable peptide blocking Pim-1 kinase, halts DU145 cell growth, causes G1 arrest and apoptosis, inert to RPWE-1 cells at 10-20 μM.Formula:C111H211N59O26SPurezza:98%Colore e forma:SolidPeso molecolare:2820.33VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Formula:C27H27N3O3Colore e forma:SolidPeso molecolare:441.522STAT3-IN-41
STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.Formula:C22H30F3NO7Colore e forma:SolidPeso molecolare:477.471Eflepedocokin alfa
CAS:Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.Colore e forma:LiquidSTAT3 ligand 5
STAT3ligand 5 is a STAT3 ligand, serving as a target protein ligand for the synthesis of the PROTAC degrader [SD-436].Formula:C36H39F4N6O12PSColore e forma:SolidPeso molecolare:886.76JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Colore e forma:Odour SolidOSM-SMI-10B
OSM-SMI-10B, a variant of OSM-SMI-10, inhibits OSM-induced STAT3 activation in cancer cells.Formula:C21H14O7Colore e forma:SolidPeso molecolare:378.33Neocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Formula:C31H42O8Purezza:98%Colore e forma:SolidPeso molecolare:542.66PROTAC TYK2 degrader-1
CAS:PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.Formula:C40H41N13O7Peso molecolare:815.84Pumecitinib
CAS:<p>Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.</p>Formula:C17H20N8O2SPurezza:99.94%Colore e forma:SoildPeso molecolare:400.46JAK-2/3-IN-1
CAS:JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.Formula:C20H12ClN3OColore e forma:SolidPeso molecolare:345.79APTSTAT3-9R
APTSTAT3-9R-9R blocks STAT3 (Ki: 231 nmol/L), hindering cancer cell growth and resistance.Formula:C223H330N80O51Purezza:98%Colore e forma:SolidPeso molecolare:4947.51STAT3-IN-39
CAS:STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Formula:C20H17F3N2O3SColore e forma:SolidPeso molecolare:422.42SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Formula:C36H36N10O5Colore e forma:SolidPeso molecolare:688.74STAT3-IN-37
CAS:STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formula:C23H25Cl2N5O2Colore e forma:SolidPeso molecolare:474.38Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Formula:C25H28N6O3Colore e forma:SolidPeso molecolare:460.53Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour SolidRef: TM-L1600
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaSTAT3 HiBiT degrader 1
CAS:STAT3HiBiT degrader 1 is a potent degrader of STAT3HiBiT, exhibiting a DC50 of less than 0.05 μM in A549 cells.Formula:C58H63F4N10O14PSColore e forma:SolidPeso molecolare:1263.21PM-81I
CAS:PM-81I: Potent STAT6 inhibitor for allergic and pulmonary conditions, cancer research. Reduces STAT6 phosphorylation.Formula:C43H58F2N3O10PColore e forma:SolidPeso molecolare:845.91SJ1008030
CAS:<p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>Formula:C42H43N13O7SColore e forma:SolidPeso molecolare:873.94JI069
CAS:<p>JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.</p>Formula:C15H12Cl2N2O4SPurezza:98.01%Colore e forma:SolidPeso molecolare:387.24MR44397
MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.Formula:C23H26N4O2SColore e forma:SolidPeso molecolare:422.54AS2553627
CAS:AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38DBL-6-13
DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.Formula:C25H38N4O3Colore e forma:SolidPeso molecolare:442.59JAK2-IN-10
CAS:JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Formula:C33H33D3FN9O2Colore e forma:SolidPeso molecolare:612.71TYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Formula:C23H21FN4O2Colore e forma:SolidPeso molecolare:404.16485Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Formula:C144H227N41O47Colore e forma:SolidPeso molecolare:3284.59SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Formula:C41H46N12O5SColore e forma:SolidPeso molecolare:818.95Deuruxolitinib
CAS:Deuruxolitinib functions as an inhibitor of JAK1/2.Formula:C17H18N6Colore e forma:SolidPeso molecolare:314.41PROTAC TYK2 degradation agent1
CAS:PROTAC TYK2 Agent1 selectively degrades TYK2, with a 14 nM DC50, for autoimmune research.Formula:C55H69N13O7SPurezza:98%Colore e forma:SolidPeso molecolare:1056.28Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
CAS:Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.Formula:C88H138N20O34P2Purezza:98%Colore e forma:SolidPeso molecolare:2082.1DU-14 (PTP1B/TC-PTP PROTAC)
CAS:DU-14 (PTP1B/TC-PTPPROTAC) is a potent and selective dual PROTAC degrader for PTP1B and TC-PTP, exhibiting IC50 values of 24.2 nM and 30.1 nM for the phosphatase activity of PTP1B and TC-PTP, respectively. It enhances IFN-γ signaling, promotes T cell activation, and possesses antitumor activity.Formula:C74H85BrF2N9O14PSPeso molecolare:1505.46WDR5 ligand 2
CAS:<p>WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.</p>Formula:C29H31F3N4O4Colore e forma:SolidPeso molecolare:556.576PROTAC STAT3 degrader-2
CAS:<p>PROTAC STAT3 degrader-2 selectively breaks down STAT3 (DC50: 3.54μM, Molm-16) with cancer research potential.</p>Formula:C59H60F2N9O13PColore e forma:SolidPeso molecolare:1172.13Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedColore e forma:Odour SolidRef: TM-L2200
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaJAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Formula:C22H23FN4O3SColore e forma:SolidPeso molecolare:442.51AK-2292
AK-2292: potent STAT5 PROTAC degrader, DC50 0.10 μM, degrades STAT5A/B, may shrink leukemia tumors in mice.Formula:C52H54F2N7O10PS2Colore e forma:SolidPeso molecolare:1070.13TP-5801 TFA
TP-5801 TFA is an orally active inhibitor of TNK1, a non-receptor tyrosine kinase, with an IC50 value of 1.40 nM, demonstrating anti-tumor activity [1].Formula:C26H32BrF3N8O3Purezza:98%Colore e forma:SolidPeso molecolare:641.48STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).Formula:C30H33FN4O3SColore e forma:SolidPeso molecolare:548.67FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidJAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidCMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formula:C46H59N9O7Purezza:98%Colore e forma:SolidPeso molecolare:850.03S-Ruxolitinib
CAS:<p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>Formula:C17H18N6Purezza:98%Colore e forma:SolidPeso molecolare:306.37Povorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Formula:C23H25F5N7O5PPurezza:99.57%Colore e forma:SolidPeso molecolare:605.45Ref: TM-T39113L
1mg48,00€5mg101,00€10mg154,00€25mg250,00€50mg359,00€100mg487,00€200mg655,00€1mL*10mM (DMSO)Prezzo su richiestaTYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Colore e forma:Odour SolidPim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Formula:C11H9NO3SPurezza:99.78%Colore e forma:SolidPeso molecolare:235.26Atinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Formula:C16H17FN6O3Purezza:99.36%Colore e forma:SolidPeso molecolare:360.35Ref: TM-T39646
1mg138,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€1mL*10mM (DMSO)264,00€DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Formula:C26H35N7O5Colore e forma:SolidPeso molecolare:525.6SD-436
CAS:SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.Formula:C58H62F4N9O14PSPurezza:99.34%Colore e forma:SolidPeso molecolare:1248.2Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Formula:C17H17N7O2SPurezza:99.88%Colore e forma:SolidPeso molecolare:383.43Ref: TM-T38571
1mg92,00€5mg230,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€1mL*10mM (DMSO)251,00€CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formula:C22H19F2N5O2Purezza:99.38%Colore e forma:SolidPeso molecolare:423.42Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Formula:C32H33F4N9O5Colore e forma:SolidPeso molecolare:699.66AK-1690
CAS:AK-1690 is a potent and selective STAT6 PROTAC degrader that induces degradation of STAT6 proteins in cells and depletes STAT6 proteins in mouse tissues.Formula:C51H56F2N5O11PSPurezza:99.95%Colore e forma:SolidPeso molecolare:1016.055,15-DPP
CAS:5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].Formula:C32H22N4Colore e forma:SolidPeso molecolare:462.54Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Formula:C20H18FN5O3Purezza:98.05%Colore e forma:SolidPeso molecolare:395.39Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formula:C26H24N2O11P2Purezza:97.18%Colore e forma:SolidPeso molecolare:602.42FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purezza:97% - 97.90%Colore e forma:SolidPeso molecolare:464.55Ref: TM-T6838
2mg46,00€5mg66,00€10mg93,00€25mg124,00€50mg197,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)72,00€Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurezza:98.03% - ≥95%Colore e forma:SolidPeso molecolare:425.5RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Formula:C23H25NO·HClPurezza:98.05%Colore e forma:SolidPeso molecolare:367.91SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurezza:99.11%Colore e forma:SolidPeso molecolare:414.48Ref: TM-T9195
1mg80,00€5mg183,00€10mg298,00€25mg512,00€50mg817,00€100mg1.311,00€1mL*10mM (DMSO)167,00€Ritlecitinib
CAS:Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.Formula:C15H19N5OPurezza:98.82% - 99.92%Colore e forma:SolidPeso molecolare:285.34Ref: TM-T5382
2mg39,00€5mg56,00€10mg96,00€25mg216,00€50mg306,00€100mg430,00€200mg628,00€1mL*10mM (DMSO)77,00€JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purezza:99.94% - 99.94%Colore e forma:SolidPeso molecolare:350.37Protosappanin A
CAS:<p>Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.</p>Formula:C15H12O5Purezza:99.42% - 99.82%Colore e forma:SolidPeso molecolare:272.25
