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Segnalazione JAK/STAT

Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 322 prodotti di "Segnalazione JAK/STAT"

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  • JAK-IN-11
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    JAK-IN-11

    CAS:
    <p>JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.</p>
    Formula:C23H22FN5O4S
    Purezza:99.75%
    Colore e forma:Solid
    Peso molecolare:483.52

    Ref: TM-T12549

  • CX-6258
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    CX-6258

    CAS:
    <p>CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.</p>
    Formula:C26H24ClN3O3
    Purezza:97.46%
    Colore e forma:Solid
    Peso molecolare:461.94

    Ref: TM-T1834

  • JAK-IN-20
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    JAK-IN-20

    CAS:
    <p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>
    Formula:C28H30FN7O2
    Colore e forma:Solid
    Peso molecolare:515.58

    Ref: TM-T63581

  • Niclosamide monohydrate
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    Niclosamide monohydrate

    CAS:
    <p>Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication.</p>
    Formula:C13H10Cl2N2O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:345.14

    Ref: TM-T23068

  • Peficitinib hydrochloride
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    Peficitinib hydrochloride

    CAS:
    <p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>
    Formula:C18H23ClN4O2
    Colore e forma:Solid
    Peso molecolare:362.86

    Ref: TM-T61365

  • TK4b
    Targetmol
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    TK4b

    CAS:
    <p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) &amp; 19.40 nM (JAK2).</p>
    Formula:C21H22N2O2
    Colore e forma:Solid
    Peso molecolare:334.41

    Ref: TM-T61020

  • TK4g
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    TK4g

    CAS:
    <p>TK4g, a potent JAK inhibitor, has IC50s of 12.61 nM (JAK2) &amp; 15.80 nM (JAK3); promising for lymphoid diseases &amp; leukemia research.</p>
    Formula:C19H19N3O4S
    Colore e forma:Solid
    Peso molecolare:385.44

    Ref: TM-T61698

  • JAK-2/3-IN-2
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    JAK-2/3-IN-2

    CAS:
    <p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 &amp; JAK3 inhibitor with IC50s of 23.85 nM (JAK2) &amp; 18.9 nM (JAK3).</p>
    Formula:C19H19ClN2OS
    Colore e forma:Solid
    Peso molecolare:358.89

    Ref: TM-T61323

  • XZH-5
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    XZH-5

    CAS:
    <p>XZH-5 is an inhibitor of STAT3.</p>
    Formula:C22H25F6N5O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:537.46

    Ref: TM-T26340

  • JAK-IN-14
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    JAK-IN-14

    CAS:
    <p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>
    Formula:C19H15FN4O
    Purezza:98.27%
    Colore e forma:Solid
    Peso molecolare:334.35

    Ref: TM-T9764

  • TyK2-IN-2
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    TyK2-IN-2

    CAS:
    TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
    Formula:C16H18N6O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:310.35

    Ref: TM-T13232

  • JAK-IN-18
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    JAK-IN-18

    CAS:
    <p>"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."</p>
    Formula:C27H28F2N6O3
    Colore e forma:Solid
    Peso molecolare:522.55

    Ref: TM-T63658

  • JAK3-IN-12
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    JAK3-IN-12

    CAS:
    <p>JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.</p>
    Formula:C19H19N5O4S
    Colore e forma:Solid
    Peso molecolare:413.45

    Ref: TM-T62114

  • Tyk2-IN-5
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    Tyk2-IN-5

    CAS:
    Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
    Formula:C21H19FN8O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:434.43

    Ref: TM-T13234

  • Tyk2-IN-7
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    Tyk2-IN-7

    CAS:
    Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).
    Formula:C18H15D3N6O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:401.46

    Ref: TM-T13235

  • MS-1020
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    MS-1020

    CAS:
    MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.
    Formula:C21H18N2O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:346.38

    Ref: TM-T28113

  • 1,2,3,4,5,6-Hexabromocyclohexane
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    1,2,3,4,5,6-Hexabromocyclohexane

    CAS:
    <p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>
    Formula:C6H6Br6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:557.54

    Ref: TM-T22462

  • OICR-0547
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    OICR-0547

    CAS:
    <p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>
    Formula:C28H29F3N4O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:542.55

    Ref: TM-T12290

  • JAK3-IN-9
    Targetmol
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    JAK3-IN-9

    CAS:
    <p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>
    Formula:C17H23N5O4S
    Colore e forma:Solid
    Peso molecolare:393.46

    Ref: TM-T61814

  • EP009
    Targetmol
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    EP009

    CAS:
    <p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>
    Formula:C14H24O2
    Colore e forma:Solid
    Peso molecolare:224.34

    Ref: TM-T27274