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Segnalazione JAK/STAT

Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 322 prodotti di "Segnalazione JAK/STAT"

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  • INCB16562
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    INCB16562

    CAS:
    <p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>
    Formula:C19H11Cl2N5
    Colore e forma:Solid
    Peso molecolare:380.23

    Ref: TM-T68306

  • BP-5-087
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    BP-5-087

    CAS:
    <p>BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.</p>
    Formula:C36H30F8N2O6S
    Colore e forma:Solid
    Peso molecolare:770.69

    Ref: TM-T70167

  • Galiellalactone
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    Galiellalactone

    CAS:
    <p>inhibits IL-6-mediated JAK/STAT signal transduction</p>
    Formula:C11H14O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:194.23

    Ref: TM-T22796

  • CP-690550A
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    CP-690550A

    CAS:
    <p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>
    Formula:C15H21N5O2
    Colore e forma:Solid
    Peso molecolare:303.36

    Ref: TM-T31074

  • GDC-4379
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    GDC-4379

    CAS:
    <p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>
    Formula:C21H18ClF2N7O3
    Colore e forma:Solid
    Peso molecolare:489.86

    Ref: TM-T63280

  • Peficitinib hydrobromide
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    Peficitinib hydrobromide

    CAS:
    <p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>
    Formula:C18H23BrN4O2
    Colore e forma:Solid
    Peso molecolare:407.312

    Ref: TM-T33905

  • Povorcitinib
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    Povorcitinib

    CAS:
    <p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>
    Formula:C23H22F5N7O
    Colore e forma:Solid
    Peso molecolare:507.469

    Ref: TM-T39113

  • (2R,5S)-Ritlecitinib
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    (2R,5S)-Ritlecitinib

    CAS:
    <p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>
    Formula:C15H19N5O
    Colore e forma:Solid
    Peso molecolare:285.34

    Ref: TM-T60565

  • YM-341619
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    YM-341619

    CAS:
    <p>YM-341619 (AS1617612), potent STAT6 inhibitor; IC50: 0.70 nM; hinders IL-4-induced Th2 in mice; may aid allergic disease research.</p>
    Formula:C22H21F3N6O2
    Colore e forma:Solid
    Peso molecolare:458.44

    Ref: TM-T62860

  • TUL01101
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    TUL01101

    CAS:
    <p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>
    Formula:C22H25F2N5O2
    Colore e forma:Solid
    Peso molecolare:429.46

    Ref: TM-T73392

  • Stafia-1-dipivaloyloxymethyl ester
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    Stafia-1-dipivaloyloxymethyl ester

    CAS:
    <p>Stafia-1 suppresses pSTAT5a in a dose-dependent manner (0-200 μM) without affecting pSTAT5b.</p>
    Formula:C37H48FO13P
    Colore e forma:Solid
    Peso molecolare:750.74

    Ref: TM-T35917

  • MM-206
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    MM-206

    CAS:
    <p>MM-206, a cell-permeable, non-cytotoxic naphthalene sulfonamide compound, it effectively inhibits STAT3 DNA-binding activity.</p>
    Formula:C22H12F5NO3S2
    Colore e forma:Solid
    Peso molecolare:497.46

    Ref: TM-T28075

  • MC0704
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    MC0704

    <p>MC0704: STAT3 inhibitor, IC50=2.13μM, promotes apoptosis &amp; cell arrest, anti-breast cancer, for mTNBC research.</p>
    Formula:C29H21BrN4O2
    Colore e forma:Solid
    Peso molecolare:537.41

    Ref: TM-T73501

  • STAT3-IN-15
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    STAT3-IN-15

    <p>STAT3-IN-15: Potent, oral STAT3 inhibitor for IPF, blocks STAT3 phosphorylation, cell migration, and EMT.</p>
    Formula:C20H17F3N2O3S
    Colore e forma:Solid
    Peso molecolare:422.42

    Ref: TM-T73035

  • Thi-DPPY
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    Thi-DPPY

    CAS:
    <p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>
    Formula:C28H28ClN5O4S
    Colore e forma:Solid
    Peso molecolare:566.07

    Ref: TM-T64008

  • HJC0149
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    HJC0149

    CAS:
    <p>HJC0149 is a potent orally bioavailable signal transducer and activator of transcription 3 inhibitor.</p>
    Formula:C15H10ClNO4S
    Colore e forma:Solid
    Peso molecolare:335.76

    Ref: TM-T24142

  • TYK2-IN-11
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    TYK2-IN-11

    CAS:
    <p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>
    Formula:C18H17N5O3S
    Colore e forma:Solid
    Peso molecolare:383.42

    Ref: TM-T61658

  • SYK/JAK-IN-1
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    SYK/JAK-IN-1

    CAS:
    <p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>
    Formula:C24H26N8O3
    Colore e forma:Solid
    Peso molecolare:474.52

    Ref: TM-T63086

  • PF-00956980
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    PF-00956980

    CAS:
    <p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>
    Formula:C18H26N6O
    Colore e forma:Solid
    Peso molecolare:342.44

    Ref: TM-T71089

  • LLL12
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    LLL12

    CAS:
    <p>LLL12 inhibits STAT3 phosphorylation, boosting Cisplatin and Paclitaxel effects against ovarian cancer cell activities.</p>
    Formula:C14H9NO5S
    Colore e forma:Solid
    Peso molecolare:303.29

    Ref: TM-T71099