Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 322 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

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5,15-DPP
CAS:
- 22112-89-6
5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].
Formula:C₃₂H₂₂N₄
Colore e forma:Solid
Peso molecolare:462.54
Ref: TM-T21501
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Ifidancitinib
CAS:
- 1236667-40-5
Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.
Formula:C₂₀H₁₈FN₅O₃
Purezza:98.05%
Colore e forma:Solid
Peso molecolare:395.39
Ref: TM-T38623
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FLLL32
CAS:
- 1226895-15-3
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
Formula:C₂₈H₃₂O₆
Purezza:97% - 97.90%
Colore e forma:Solid
Peso molecolare:464.55
Ref: TM-T6838
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Filgotinib
CAS:
- 1206161-97-8
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
Formula:C₂₁H₂₃N₅O₃S
Purezza:98.03% - ≥95%
Colore e forma:Solid
Peso molecolare:425.5
Ref: TM-T1929
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RGB-286638 free base
CAS:
- 784210-88-4
RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.
Formula:C₂₉H₃₅N₇O₄
Purezza:98% - 99.91%
Colore e forma:Solid
Peso molecolare:545.63
Ref: TM-T2378
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JAK3-IN-6
CAS:
- 1443235-95-7
JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM
Formula:C₁₉H₁₈N₄O₃
Purezza:99.94% - 99.94%
Colore e forma:Solid
Peso molecolare:350.37
Ref: TM-T5492
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Ritlecitinib
CAS:
- 1792180-81-4
Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.
Formula:C₁₅H₁₉N₅O
Purezza:98.82% - 99.92%
Colore e forma:Solid
Peso molecolare:285.34
Ref: TM-T5382
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SHR0302
CAS:
- 1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,
Formula:C₁₈H₂₂N₈O₂S
Purezza:99.11%
Colore e forma:Solid
Peso molecolare:414.48
Ref: TM-T9195
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AG490
CAS:
- 133550-30-8
AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.
Formula:C₁₇H₁₄N₂O₃
Purezza:98.6% - 99.85%
Colore e forma:Yellow Solid
Peso molecolare:294.3
Ref: TM-T2600
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RO8191
CAS:
- 691868-88-9
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
Formula:C₁₄H₅F₆N₅O
Purezza:98% - 98.85%
Colore e forma:Solid
Peso molecolare:373.21
Ref: TM-T22142
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SMI-16a
CAS:
- 587852-28-6
SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (
Formula:C₁₃H₁₃NO₃S
Purezza:99.99%
Colore e forma:Solid
Peso molecolare:263.31
Ref: TM-T3989
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SAR-20347
CAS:
- 1450881-55-6
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
Formula:C₂₁H₁₈ClFN₄O₄
Purezza:98.99% - 99.77%
Colore e forma:Solid
Peso molecolare:444.84
Ref: TM-T4210
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XL019
CAS:
- 945755-56-6
XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.
Formula:C₂₅H₂₈N₆O₂
Purezza:99.19%
Colore e forma:Solid
Peso molecolare:444.53
Ref: TM-T3072
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Gandotinib
CAS:
- 1229236-86-5
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).
Formula:C₂₃H₂₅ClFN₇O
Purezza:99.33% - 99.86%
Colore e forma:Solid
Peso molecolare:469.94
Ref: TM-T2638
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Momelotinib HCl
CAS:
- 1380317-28-1
Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
Formula:C₂₃H₂₄Cl₂N₆O₂
Colore e forma:Solid
Peso molecolare:487.38
Ref: TM-T70823
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Atractylenolide I
CAS:
- 73069-13-3
Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.
Formula:C₁₅H₁₈O₂
Purezza:97.55% - 99.92%
Colore e forma:Solid
Peso molecolare:230.3
Ref: TM-T5S0167
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TCS-PIM-1-4a
CAS:
- 327033-36-3
SMI-4a, a Pim inhibitor, activates AMPK, halts mTORC1, and kills various myeloid/lymphoid cells (IC50=0.8-40μM).
Formula:C₁₁H₆F₃NO₂S
Purezza:99.89%
Colore e forma:Solid
Peso molecolare:273.23
Ref: TM-T4215
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Peficitinib
CAS:
- 944118-01-8
Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Formula:C₁₈H₂₂N₄O₂
Purezza:98.67% - 99.4%
Colore e forma:Solid
Peso molecolare:326.39
Ref: TM-T6933
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Tofacitinib Citrate
CAS:
- 540737-29-9
Tofacitinib Citrate (CP-690550 citrate) is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
Formula:C₂₂H₂₈N₆O₈
Purezza:99.19% - 99.75%
Colore e forma:Solid
Peso molecolare:504.49
Ref: TM-T2398
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Gusacitinib HCl
CAS:
- 2228989-14-6
Gusacitinib (ASN-002/EN-3351), a potent SYK/JAK inhibitor, has strong antitumor activity in various cancers.
Formula:C₂₄H₂₉ClN₈O₂
Colore e forma:Solid
Peso molecolare:497
Ref: TM-T69766