Segnalazione JAK/STAT

Gli inibitori della segnalazione JAK/STAT sono composti che interrompono la via della Janus chinasi (JAK) e del trasduttore e attivatore della trascrizione (STAT), coinvolta nella segnalazione delle citochine, nella crescita cellulare e nella risposta immunitaria. Questi inibitori sono strumenti importanti per studiare la regolazione di questa via e il suo ruolo in diverse malattie, tra cui tumori, disturbi immunitari e condizioni infiammatorie. Gli inibitori JAK/STAT sono anche in fase di sviluppo come terapie mirate per queste malattie. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità della segnalazione JAK/STAT per supportare la tua ricerca in biologia molecolare, oncologia e immunologia.

Sottocategorie di "Segnalazione JAK/STAT"

Trovati 322 prodotti di "Segnalazione JAK/STAT"

Purezza (%)

100

prodotti per pagina.

+ Info
WP1066
CAS:
- 857064-38-1
WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.
Formula:C₁₇H₁₄BrN₃O
Purezza:98.92% - 99.73%
Colore e forma:Solid
Peso molecolare:356.22
Ref: TM-T2156
+ Info
TP-3654
CAS:
- 1361951-15-6
TP-3654 is a second-generation Pim kinase inhibitor (Ki values against Pim-1/3: 5/42 nM).
Formula:C₂₂H₂₅F₃N₄O
Purezza:99.8% - 99.95%
Colore e forma:Solid
Peso molecolare:418.46
Ref: TM-T4523
+ Info
Protosappanin A
CAS:
- 102036-28-2
Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.
Formula:C₁₅H₁₂O₅
Purezza:99.42% - 99.82%
Colore e forma:Solid
Peso molecolare:272.25
Ref: TM-TJS1779
+ Info
BD750
CAS:
- 892686-59-8
BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in
Formula:C₁₄H₁₃N₃OS
Purezza:99.02%
Colore e forma:Solid
Peso molecolare:271.34
Ref: TM-T8546
+ Info
Peficitinib
CAS:
- 944118-01-8
Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.
Formula:C₁₈H₂₂N₄O₂
Purezza:98.67% - 99.4%
Colore e forma:Solid
Peso molecolare:326.39
Ref: TM-T6933
+ Info
ZM39923 hydrochloride
CAS:
- 1021868-92-7
ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.
Formula:C₂₃H₂₅NO·HCl
Purezza:98.05%
Colore e forma:Solid
Peso molecolare:367.91
Ref: TM-T6145
+ Info
SHR0302
CAS:
- 1445987-21-2
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,
Formula:C₁₈H₂₂N₈O₂S
Purezza:99.11%
Colore e forma:Solid
Peso molecolare:414.48
Ref: TM-T9195
+ Info
Napabucasin
CAS:
- 83280-65-3
Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.
Formula:C₁₄H₈O₄
Purezza:98.43% - 99.85%
Colore e forma:Solid
Peso molecolare:240.21
Ref: TM-T3218
+ Info
Golotimod
CAS:
- 229305-39-9
Golotimod (SCV 07) is an antimicrobial active dipeptide with immunomodulatory activity for the study of recurrent genital herpes simplex virus 2 infections.
Formula:C₁₆H₁₉N₃O₅
Purezza:99.88% - 99.98%
Colore e forma:Solid
Peso molecolare:333.34
Ref: TM-T11449L
+ Info
GS-829845
CAS:
- 1257705-09-1
GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life
Formula:C₁₇H₁₉N₅O₂S
Purezza:99.93%
Colore e forma:Solid
Peso molecolare:357.43
Ref: TM-T67905
+ Info
Cerdulatinib hydrochloride
CAS:
- 1369761-01-2
Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.
Formula:C₂₀H₂₈ClN₇O₃S
Purezza:99.85%
Colore e forma:Solid
Peso molecolare:482
Ref: TM-T6104
+ Info
CX-6258 hydrochloride
CAS:
- 1353859-00-3
CX-6258 hydrochloride (Pim-Kinase Inhibitor X) is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
Formula:C₂₆H₂₄ClN₃O₃·HCl
Purezza:96.03% - 98.60%
Colore e forma:Solid
Peso molecolare:498.4
Ref: TM-T6148
+ Info
NVP-BSK805
CAS:
- 1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
Formula:C₂₇H₂₈F₂N₆O
Purezza:98%
Colore e forma:Solid
Peso molecolare:490.55
Ref: TM-T5049
+ Info
Solrikitug
CAS:
- 2768721-24-8
Solrikitug,Anti-CRLF2 humanized IgG1κ monoclonal antibody.
Purezza:95%
Colore e forma:Liquid
Ref: TM-T9901A-527
+ Info
ZM39923
CAS:
- 273727-89-2
ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).
Formula:C₂₃H₂₅NO
Purezza:98%
Colore e forma:Solid
Peso molecolare:331.45
Ref: TM-T17295
+ Info
TLC1566-0618
CAS:
- 708218-62-6
TLC1566-0618 shows antitumor activity and targets stat.
Formula:C₂₀H₁₅NO₃S₃
Purezza:98%
Colore e forma:Solid
Peso molecolare:413.53
Ref: TM-T121011
+ Info
Golotimod TFA
CAS:
- 2828433-07-2
Golotimod TFA (SCV 07 TFA) is a dipeptide exhibiting immunomodulatory and antibacterial activity, alleviates radiation-induced oral mucositis.
Formula:C₁₈H₂₀F₃N₃O₇
Purezza:98%
Colore e forma:Soild
Peso molecolare:447.36
Ref: TM-T11449L2
+ Info
(3S,4S)-Tofacitinib
CAS:
- 1092578-47-6
(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.
Formula:C₁₆H₂₀N₆O
Purezza:98%
Colore e forma:Solid
Peso molecolare:312.37
Ref: TM-T13426L
+ Info
SD-1029
CAS:
- 118372-34-2
SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.
Formula:C₂₅H₃₂Br₂Cl₂N₂O₃
Colore e forma:Solid
Peso molecolare:639.25
Ref: TM-T24774
+ Info
K00135
CAS:
- 869650-21-5
K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
Formula:C₁₈H₁₈N₄O
Purezza:98.16%
Colore e forma:Solid
Peso molecolare:306.36
Ref: TM-T27704