STAT
Le proteine STAT sono componenti critici della via di segnalazione JAK/STAT, che trasmette segnali extracellulari da citochine e fattori di crescita al nucleo cellulare, influenzando l'espressione genica. Le proteine STAT sono coinvolte nella regolazione delle risposte immunitarie, della crescita cellulare, della differenziazione e della sopravvivenza. La disregolazione della segnalazione STAT è implicata in varie malattie, tra cui cancro, disturbi autoimmuni e infiammazione cronica. Presso CymitQuimica, offriamo una gamma completa di modulatori della via STAT per supportare la tua ricerca sulla trasduzione del segnale, immunologia e sviluppo terapeutico.
Trovati 98 prodotti di "STAT"
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Niclosamide
CAS:<p>Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.</p>Formula:C13H8Cl2N2O4Purezza:98.47% - 99.1%Colore e forma:Pale Yellow Crystals SolidPeso molecolare:327.12Fludarabine
CAS:<p>Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation.</p>Formula:C10H12FN5O4Purezza:99.65% - 99.89%Colore e forma:White SolidPeso molecolare:285.23STAT3-IN-1
CAS:<p>STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor</p>Formula:C28H29NO6Purezza:95.89% - 95.89%Colore e forma:SolidPeso molecolare:475.53Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formula:C27H42O3Purezza:99.87%Colore e forma:Flaky Or Needle CrystalPeso molecolare:414.62L002
CAS:L002 is a potent inhibitor of acetyltransferase p300 with an IC50 of 1.98 μM, blocking histone and p53 acetylation, and may treat cardiac hypertrophy.Formula:C15H15NO5SPurezza:98.59%Colore e forma:SolidPeso molecolare:321.35Nifuroxazide
CAS:Nifuroxazide (Diarlidan), an oral nitrofuran antidiarrheal, blocks STAT1/3/5 activation.Formula:C12H9N3O5Purezza:99.79% - 99.95%Colore e forma:Yellow SolidPeso molecolare:275.22Niclosamide olamine
CAS:<p>Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.</p>Formula:C15H15Cl2N3O5Purezza:99.89%Colore e forma:Bright Yellow Crystalline Physical Description Yellow Solid Insoluble In Water (Ntp 1992)Peso molecolare:388.20UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Formula:C26H35NO5Purezza:98.50%Colore e forma:SolidPeso molecolare:441.56Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purezza:99.13% - 99.92%Colore e forma:SolidPeso molecolare:414.45Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formula:C19H28O8Purezza:97.67% - 99.9%Colore e forma:White Crystalline PowderPeso molecolare:384.42Neocucurbitacin A
CAS:<p>Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].</p>Formula:C31H42O8Purezza:98%Colore e forma:SolidPeso molecolare:542.66STAT3-IN-41
<p>STAT3-IN-41 (Compound 16) is a prodrug of compound 1. It gradually releases compound 1, which inhibits the STAT3 signaling pathway. STAT3-IN-41 exhibits antitumor activity against lung cancer, hepatocellular carcinoma, and pancreatic cancer.</p>Formula:C22H30F3NO7Colore e forma:SolidPeso molecolare:477.471Eflepedocokin alfa
CAS:<p>Eflepedocokin alfa is a recombinant IL-22/IgG2-Fc protein, potentially protecting cells and enhancing immune function and tissue repair.</p>Colore e forma:LiquidSTAT3-IN-37
CAS:STAT3-IN-37 (Compound 101) is an inhibitor of STAT3, with an IC50 of 15 nM as measured by DNA-HTRF assay and 2 nM as determined through human whole blood SOCS3 qPCR assay.Formula:C23H25Cl2N5O2Colore e forma:SolidPeso molecolare:474.38STAT3-IN-39
CAS:STAT3-IN-39 (compound 10K) is an orally active inhibitor of STAT3, demonstrating effective inhibition of STAT3 phosphorylation with an IC50 of 0.47 μM in NIH-3T3 cells. It hinders TGF-β1-induced fibrotic responses and prevents epithelial-mesenchymal transition in A549 cells. STAT3-IN-39 is applicable for research related to idiopathic pulmonary fibrosis.Formula:C20H17F3N2O3SColore e forma:SolidPeso molecolare:422.42STAT3-IN-23
CAS:STAT3-IN-23 (PY*LKTK) acts as a potent inhibitor of STAT3 [1].Formula:C36H61N8O12PPeso molecolare:828.89MNK8
CAS:MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formula:C15H12N2O2Purezza:99.74%Colore e forma:SolidPeso molecolare:252.27STAT4-IN-1
<p>STAT4-IN-1 is a STAT4 inhibitor with a Ki of 0.35 μM. It holds promise for research into autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.</p>Colore e forma:Odour Solid(R)-Lisofylline
CAS:(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM).Formula:C13H20N4O3Purezza:99.50% - 99.85%Colore e forma:SolidPeso molecolare:280.32JAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Colore e forma:Odour SolidCMD178
CMD178 is an important polypeptide that consistently reduces the expression of Foxp3 and STAT5 by inhibiting the IL-2/s IL-2Rα signaling pathway.Formula:C46H59N9O7Purezza:98%Colore e forma:SolidPeso molecolare:850.03STX-0119
CAS:<p>STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.</p>Formula:C22H14N4O3Purezza:99.61%Colore e forma:SolidPeso molecolare:382.37STAT5-IN-3
<p>STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer properties. It works by blocking the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites, significantly reducing the expression of the STAT5B protein. This leads to the inhibition of downstream gene transcription, thereby preventing the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 has significant potential in overcoming chemotherapy resistance.</p>Formula:C25H27N5OColore e forma:SolidPeso molecolare:413.51Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Formula:C30H26N2O2Colore e forma:SolidPeso molecolare:446.54STAT3-IN-31
<p>STAT3-IN-31 (compound K2071), derived from STATtic, acts as an inhibitor of both STAT3 and mitotic processes. This compound interrupts mitotic progression and impacts the formation of the mitotic spindle. Additionally, STAT3-IN-31 hampers migration in glioblastoma cells, suppresses cellular proliferation within tumor spheroids, induces senescence in glioblastoma, and inhibits the growth of Temozolomide-resistant cells while reducing the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein (MCP-1).</p>Formula:C16H15NO3SColore e forma:SolidPeso molecolare:301.36STAT3-IN-34
<p>STAT3-IN-34 (Compound 15E) acts as a STAT3 inhibitor, blocking both the nuclear translocation and the transcriptional regulator activity of STAT3. It effectively inhibits HaCaT cell proliferation with an IC50 value of 0.008 μM. Additionally, STAT3-IN-34 reduces IL-17A expression and mitigates Imiquimod-induced psoriasis in mouse models.</p>Formula:C19H16N2O4SColore e forma:SolidPeso molecolare:368.41Balsalazide
CAS:Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Formula:C17H15N3O6Purezza:99.31%Colore e forma:Yellow To Orange Crystalline PowderPeso molecolare:357.32Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formula:C26H24N2O11P2Purezza:97.18%Colore e forma:SolidPeso molecolare:602.42SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formula:C21H13ClF3N3O2Purezza:98.44%Colore e forma:SolidPeso molecolare:431.8SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Formula:C29H27F5N2O5SPurezza:98% - 99.12%Colore e forma:SolidPeso molecolare:610.59SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurezza:99.56%Colore e forma:SolidPeso molecolare:336.15Pimozide
CAS:Pimozide: antipsychotic that blocks type 2 dopamine, alpha-adrenergic, and 5-HT2 receptors, reducing tics and delusions.Formula:C28H29F2N3OPurezza:99.63% - >99.99%Colore e forma:SolidPeso molecolare:461.55WP1066
CAS:<p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>Formula:C17H14BrN3OPurezza:98.92% - 99.73%Colore e forma:SolidPeso molecolare:356.22Cucurbitacin I
CAS:<p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>Formula:C30H42O7Purezza:96.69% - 99.8%Colore e forma:SolidPeso molecolare:514.65RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purezza:99.30%Colore e forma:SolidPeso molecolare:312.37Cryptotanshinone
CAS:Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.Formula:C19H20O3Purezza:97.94% - ≥95%Colore e forma:Orange Needle CrystalPeso molecolare:296.36Scutellarin
CAS:Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.Formula:C21H18O12Purezza:97.12% - 99.75%Colore e forma:SolidPeso molecolare:462.36Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purezza:99.97% - >99.99%Colore e forma:SolidPeso molecolare:346.42AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formula:C16H14Cl2N8OPurezza:>99.99%Colore e forma:SolidPeso molecolare:405.24Atranorin
CAS:Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formula:C19H18O8Purezza:98.76% - 99.57%Colore e forma:SolidPeso molecolare:374.34HO-3867
CAS:HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.Formula:C28H30F2N2O2Purezza:91.18% - 99.21%Colore e forma:SolidPeso molecolare:464.55S3I-201
CAS:S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Formula:C16H15NO7SPurezza:97.83%Colore e forma:SolidPeso molecolare:365.36Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formula:C25H24O6Purezza:98.68% - 99.8%Colore e forma:SolidPeso molecolare:420.45STAT5-IN-1
CAS:<p>STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.</p>Formula:C16H11N3O3Purezza:99.44% - ≥95%Colore e forma:SolidPeso molecolare:293.28Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formula:C14H8O4Purezza:98.43% - 99.85%Colore e forma:SolidPeso molecolare:240.21Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purezza:96.66% - 99.93%Colore e forma:SolidPeso molecolare:332.39HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formula:C15H14Cl3N3O4Purezza:99.01% - 99.06%Colore e forma:SolidPeso molecolare:406.64Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formula:C14H5F6N5OPurezza:98% - 98.85%Colore e forma:SolidPeso molecolare:373.21
