MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 902 prodotti per "MAPK".
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HI-TOPK-032
CAS:HI-TOPK-032 is an effective and specific inhibitor of TOPK.Formula:C20H11N5OSPurezza:98.52%Colore e forma:SolidPeso molecolare:369.4AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formula:C32H40N8O5SPurezza:98.96%Colore e forma:SolidPeso molecolare:648.78Ref: TM-T14360
1mg54,00€2mg77,00€5mg114,00€1mL*10mM (DMSO)164,00€10mg167,00€25mg281,00€50mg401,00€100mg567,00€500mg1.161,00€MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formula:C22H24N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:388.47MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:358.39Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Formula:C19H18FN3O4Purezza:99.84%Colore e forma:SolidPeso molecolare:371.36Ref: TM-T68134
1mg122,00€5mg289,00€1mL*10mM (DMSO)311,00€10mg432,00€25mg707,00€50mg973,00€100mg1.333,00€500mg2.665,00€ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purezza:99.87%Colore e forma:SolidPeso molecolare:339.43ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Formula:C25H20N4O2Purezza:99.72% - 99.79%Colore e forma:SolidPeso molecolare:408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formula:C5H3N5O2S3Purezza:98.39%Colore e forma:SolidPeso molecolare:261.3MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formula:C15H12ClN5Purezza:98.07%Colore e forma:White SolidPeso molecolare:297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purezza:97.78%Colore e forma:SolidPeso molecolare:430.84Ref: TM-T10376
1mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formula:C25H19ClF2N4O3SPurezza:97.46%Colore e forma:SolidPeso molecolare:528.96Ref: TM-T40286
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg86,00€5mg177,00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurezza:99.03%Colore e forma:Yellow SolidPeso molecolare:528.49MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Colore e forma:Odour SolidZ16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formula:C18H17N3O4SPurezza:99.18%Colore e forma:SolidPeso molecolare:371.41Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Colore e forma:Odour SolidERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Formula:C23H20ClN5O2SPeso molecolare:465.10262MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Colore e forma:Odour SolidRef: TM-L1400
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaKRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Colore e forma:SolidPeso molecolare:1088.24Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurezza:99.82%Colore e forma:SolidPeso molecolare:319.38Ref: TM-T67942
1mg54,00€5mg116,00€10mg172,00€1mL*10mM (DMSO)180,00€25mg278,00€50mg371,00€100mg510,00€200mg687,00€ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Formula:C36H43N7O3Colore e forma:SolidPeso molecolare:621.34274
