MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 894 prodotti di "MAPK"
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(S)-p38 MAPK Inhibitor III
CAS:(S)-p38 MAPK inhibitor III: a cell-permeable, methylsulfanylimidazole; IC50s: 0.90 µM for p38 MAPK, 0.37 µM TNF-α, 0.044 µM IL-1β.Formula:C23H21FN4SColore e forma:SolidPeso molecolare:404.5J30-8
CAS:J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formula:C17H9ClFN3O2SPurezza:99.90%Colore e forma:SolidPeso molecolare:373.79ZG-10
CAS:ZG-10 (JNK-IN-2) is an inhibitor of JNK, blocking JNK1, JNK2, and JNK3, and is used in studies of SARS-CoV-2 virus infection.Formula:C28H27N7O2Purezza:99.41% - 99.91%Colore e forma:SolidPeso molecolare:493.56(R)-PD 0325901CL
CAS:(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.Formula:C16H14ClF2IN2O4Colore e forma:SolidPeso molecolare:498.65RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Formula:C23H25N3O3Colore e forma:SolidPeso molecolare:391.46RAF-IN-1
CAS:RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.Formula:C26H22F3N3O4Colore e forma:SolidPeso molecolare:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Formula:C30H39ClN8OPurezza:98%Colore e forma:SolidPeso molecolare:563.14Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Formula:C22H15N3O5SColore e forma:SolidPeso molecolare:433.44RSK2-IN-3
CAS:<p>RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.</p>Formula:C24H26N4O5Colore e forma:SolidPeso molecolare:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Formula:C18H20N6O4SColore e forma:SolidPeso molecolare:416.45Nek2-IN-5
CAS:Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).Formula:C15H12N6OPurezza:98.11%Colore e forma:SolidPeso molecolare:292.3HPK1-IN-28
CAS:HPK1-IN-28 inhibits HPK1, boosts anti-tumor immunity, and shows promise in immune disease research per patent WO2021175270A1.Formula:C25H22F3N5O4Colore e forma:SolidPeso molecolare:513.47JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Formula:C24H21BrFN5O5SColore e forma:SolidPeso molecolare:590.42TAK1/MAP4K2 inhibitor 1
CAS:TAK1/MAP4K2 inhibitor 1 (compound 5) is a dual kinase inhibitor of TAK1 and MAP4K2 with IC50 values of 41.1 nM and 18.2 nM, respectively.Formula:C29H31F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:552.59Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formula:C26H28BrF3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:565.43p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Formula:C12H4Cl6O4SColore e forma:SolidPeso molecolare:456.94KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Formula:C30H37N3O5Colore e forma:SolidPeso molecolare:519.63KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Formula:C32H33F2N5O5SColore e forma:SolidPeso molecolare:637.7JNK3 inhibitor-4
CAS:<p>JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.</p>Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Formula:C26H28N6OColore e forma:SolidPeso molecolare:440.54
