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MAPK

MAPK

Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.

Trovati 894 prodotti di "MAPK"

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  • KRAS inhibitor-17
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    KRAS inhibitor-17

    CAS:
    KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.
    Formula:C21H18Cl2FN3O2S
    Colore e forma:Solid
    Peso molecolare:466.36

    Ref: TM-T62981

  • BRAF V600E/CRAF-IN-2
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    BRAF V600E/CRAF-IN-2

    CAS:
    Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.
    Formula:C30H30F3N5O2
    Colore e forma:Solid
    Peso molecolare:549.59

    Ref: TM-T63882

  • KRAS4b-PDEδ stabilizer C19
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    KRAS4b-PDEδ stabilizer C19

    CAS:
    KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via
    Formula:C18H20Cl2N2O3
    Colore e forma:Solid
    Peso molecolare:383.27

    Ref: TM-T32419

  • SCH 51344
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    SCH 51344

    CAS:
    SCH 51344 inhibits Ras induced malignant transformation. SCH 51344 prevents anchorage-independent growth of oncogene transformed fibroblasts [1].
    Formula:C16H20N4O3
    Colore e forma:Solid
    Peso molecolare:316.36

    Ref: TM-T21676

  • LX-3
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    LX-3

    CAS:
    LX-3 activates p38 MAPK, enabling expression of genes normally silenced by DNA methylation.
    Formula:C20H13BrN4OS
    Colore e forma:Solid
    Peso molecolare:437.31

    Ref: TM-T69321

  • KRAS G12C inhibitor 47
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    KRAS G12C inhibitor 47

    CAS:
    KRAS G12C inhibitor 47 strongly blocks KRAS G12C (IC50: 0.172 μM) and p-ERK in cells; promising for pancreatic, colorectal, lung cancers.
    Formula:C30H28ClFN4O3
    Colore e forma:Solid
    Peso molecolare:547.02

    Ref: TM-T63863

  • SOS1-IN-3
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    SOS1-IN-3

    CAS:
    SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity.
    Formula:C21H21F3N4O
    Colore e forma:Solid
    Peso molecolare:402.41

    Ref: TM-T61963

  • SOS1 activator 1
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    SOS1 activator 1

    CAS:
    SOS1 activator 1 enhances SOS1's GDP-GTP exchange on Ras (Kd: 44 nM).
    Formula:C26H32ClFN6
    Colore e forma:Solid
    Peso molecolare:483.02

    Ref: TM-T63201

  • RMM-46
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    RMM-46

    CAS:
    RMM-46 is a reversible covalent inhibitor with high ligand efficiency and selectivity for MSK/RSK family kinases.
    Formula:C24H26N4O5
    Purezza:98.89%
    Colore e forma:Solid
    Peso molecolare:450.49

    Ref: TM-T26103

  • 6-T-GDP
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    6-T-GDP

    CAS:
    6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.
    Formula:C10H15N5O10P2S
    Colore e forma:Solid
    Peso molecolare:459.27

    Ref: TM-T88704

  • GDC-0879
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    GDC-0879

    CAS:
    GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.
    Formula:C19H18N4O2
    Purezza:99.62%
    Colore e forma:Solid
    Peso molecolare:334.37

    Ref: TM-T6320

  • mSIRK
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    mSIRK

    CAS:
    mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.
    Formula:C93H150N20O25
    Purezza:99.26%
    Colore e forma:Solid
    Peso molecolare:1948.31

    Ref: TM-T80548

  • Tpl2-IN-I
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    Tpl2-IN-I

    CAS:
    Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.
    Formula:C21H14ClFN6
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:404.83

    Ref: TM-T26284

  • NSC1011
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    NSC1011

    CAS:
    NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).
    Formula:C23H18N2O3
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:370.4

    Ref: TM-T28201

  • AZD6703 free base
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    AZD6703 free base

    CAS:
    AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).
    Formula:C24H27N5O2
    Colore e forma:Solid
    Peso molecolare:417.5

    Ref: TM-T26721

  • Kobe2601
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    Kobe2601

    CAS:
    Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.
    Formula:C13H10FN5O4S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:351.31

    Ref: TM-T24267

  • GSK329
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    GSK329

    CAS:
    GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.
    Formula:C19H14Cl2F3N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:472.25

    Ref: TM-T24109

  • HCI-2184
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    HCI-2184

    CAS:
    HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.
    Formula:C23H28ClN7O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:502.03

    Ref: TM-T24130

  • GSK649A
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    GSK649A

    CAS:
    GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.
    Formula:C15H12ClFN6OS
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:378.81

    Ref: TM-T27486

  • CP-281384
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    CP-281384

    CAS:
    CP-281384 is a potent, p38alpha-selective inhibitor.
    Formula:C18H14F2N4O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:340.33

    Ref: TM-T27062