MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 894 prodotti di "MAPK"
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RBC6
CAS:RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.Formula:C16H14Cl2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:365.21CP-944629
CAS:CP-944629 is a novel, potent, and selective inhibitor of p38alpha.Formula:C19H15F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.34BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formula:C29H32ClN5O4Purezza:98.81%Colore e forma:SolidPeso molecolare:550.05PF-05381941
CAS:PF-05381941 is a selective and potent dual inhibitor of TAK1 and p38α that inhibits the kinase activity of TAK1 by binding to its active site.Formula:C27H26N6O2Purezza:98.04%Colore e forma:SolidPeso molecolare:466.53MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Formula:C24H20N4O4Purezza:98%Colore e forma:SolidPeso molecolare:428.44PAF (C16)
CAS:<p>PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability.</p>Formula:C26H54NO7PPurezza:98%Colore e forma:SolidPeso molecolare:523.68B-Raf IN 13
CAS:<p>B-Raf IN 13 is a potent B-Raf inhibitor with anticancer activity.B-Raf IN 13 has an IC50 of 3.55 nM in the BRAF V600E enzyme assay.</p>Formula:C19H19ClFN3O4SPurezza:99.41% - >99.99%Colore e forma:SoildPeso molecolare:439.89KRAS G12D inhibitor 10
CAS:KRAS G12D inhibitor 10 targets KRAS G12D in cancer research (WO2021108683A1, compound 34).Formula:C33H41ClN8O2Colore e forma:SolidPeso molecolare:617.18GGTI-286
CAS:GGTI-286: GGTase I inhibitor, cell-permeable, IC50=2μM. Strongly blocks Rap1A geranylation; less effective on H-Ras, Ras4B IC50=1μM.Formula:C23H31N3O3SColore e forma:SolidPeso molecolare:429.58LY-2584702 hydrochloride
CAS:<p>Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.</p>Formula:C21H20ClF4N7Purezza:98%Colore e forma:SolidPeso molecolare:481.88MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purezza:97.23%Colore e forma:OilPeso molecolare:508.65KYA1797
CAS:KYA1797 inhibits Wnt/ß-catenin, targeting axin, and promotes ß-catenin/Ras decay, halting APC/KRAS mutant CRC growth.Formula:C17H12N2O6S2Purezza:98%Colore e forma:SolidPeso molecolare:404.42RSK2-IN-2
CAS:RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 ( RSK2 ) kinase which also inhibits MSK1, MSK2, and RSK3 [1].Formula:C16H11N5OColore e forma:SolidPeso molecolare:289.29GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purezza:98%Colore e forma:SolidPeso molecolare:304.38B-Raf IN 8
CAS:B-Raf IN 8: strong B-Raf inhibitor (70.65 nM IC50); combats liver, colon, breast & prostate cancer with IC50s from 9.78 to 29.85 μM.Formula:C18H17N3O2Colore e forma:SolidPeso molecolare:307.35(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formula:C18H16N6S2Colore e forma:SolidPeso molecolare:380.49HPK1-IN-24
CAS:HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].Formula:C19H14FN5Colore e forma:SolidPeso molecolare:331.35Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Colore e forma:SolidPeso molecolare:403.9
