Ras
Le proteine Ras sono piccole GTPasi che agiscono come interruttori molecolari nella via di segnalazione MAPK, controllando la crescita, la differenziazione e la sopravvivenza cellulare. Ras attivato avvia una cascata di segnalazione che include Raf, MEK ed ERK, portando a varie risposte cellulari. Le mutazioni nei geni Ras sono comuni nei tumori, rendendo Ras un importante focus della ricerca sul cancro. Presso CymitQuimica, offriamo una gamma di modulatori di Ras per supportare la tua ricerca in biologia del cancro, trasduzione del segnale e sviluppo terapeutico.
Trovati 175 prodotti per "Ras".
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K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formula:C31H33ClN4O4Purezza:99.41%Colore e forma:White SolidPeso molecolare:561.071Ketoconazole
CAS:Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Formula:C26H28Cl2N4O4Purezza:99.53% - 99.95%Colore e forma:White SolidPeso molecolare:531.43ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purezza:97.78%Colore e forma:SolidPeso molecolare:430.84BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purezza:99.2% - 99.66%Colore e forma:SolidPeso molecolare:462.47MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purezza:96.76% - 97.3%Colore e forma:Yellow SolidPeso molecolare:565.7085HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Formula:C19H21N3OSPurezza:98.05%Colore e forma:SolidPeso molecolare:339.455MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formula:C22H18N4Purezza:98.07% - 99.52%Colore e forma:SolidPeso molecolare:338.41MAPK Inhibitor Library
A unique collection of xnum cancer cell differentiation inducing compounds for high throughput and high content screening;Colore e forma:Odour SolidSotorasib-D7
Sotorasib-D7 is a deuterium-labeled version of Sotorasib. Sotorasib (T8684) (AMG-510) is a potent, orally bioavailable, selective covalent inhibitor of KRAS G12C. It locks KRAS G12C in the inactive GDP-bound state and causes regression of locally advanced or metastatic non-small cell lung cancer (NSCLC) with KRAS G12C mutation.MC 976
CAS:MC 976 is a derivative of Vitamin D3.Formula:C27H42O3Purezza:98%Colore e forma:SolidPeso molecolare:414.63pan-KRAS-IN-8
pan-KRAS-IN-8 (Compound 38) is an inhibitor of the human tumor mutated gene KRAS. It effectively suppresses the proliferation of KRAS mutant cells AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.07 nM and 0.18 nM, respectively.Formula:C48H61N7O7SPeso molecolare:879.43532GGDPS-IN-1
GGDPS-IN-1 (Compound 37) is an inhibitor of geranylgeranyl diphosphate synthase (GGDPS) with an IC50 of 49.4 nM, disrupting protein geranylgeranylation in myeloma cells.Formula:C15H28N4O6P2Colore e forma:SolidPeso molecolare:422.14841RAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 Free Base is a highly potent RAS GTPase inhibitor with antitumor activity.Formula:C25H27ClFN5Colore e forma:White SolidPeso molecolare:451.97ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formula:C26H24FNO5Purezza:98.82%Colore e forma:Yellow SolidPeso molecolare:449.47KRAS-IN-47
CAS:KRAS-IN-47 (Example 28) is a KRAS inhibitor with an IC50 value of less than 50 nM for KRAS G12V. It is applicable in cancer research.Formula:C33H29F5N6O2Peso molecolare:638.64KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Colore e forma:SolidPeso molecolare:1088.24TAT-PAK18 R192A
TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.Formula:C143H247N55O37Peso molecolare:3326.91369(RS)-G12Di-1
(RS)-G12Di-1 is a selective covalent inhibitor of K-Ras-G12D.Formula:C37H35FN6O4Colore e forma:SolidPeso molecolare:646.27038ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Formula:C36H43N7O3Colore e forma:SolidPeso molecolare:621.34274KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Colore e forma:Odour Solid
