Ras
Le proteine Ras sono piccole GTPasi che agiscono come interruttori molecolari nella via di segnalazione MAPK, controllando la crescita, la differenziazione e la sopravvivenza cellulare. Ras attivato avvia una cascata di segnalazione che include Raf, MEK ed ERK, portando a varie risposte cellulari. Le mutazioni nei geni Ras sono comuni nei tumori, rendendo Ras un importante focus della ricerca sul cancro. Presso CymitQuimica, offriamo una gamma di modulatori di Ras per supportare la tua ricerca in biologia del cancro, trasduzione del segnale e sviluppo terapeutico.
Trovati 156 prodotti di "Ras"
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KRAS G12C inhibitor 14
CAS:KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of 18 nM [1].Formula:C24H19ClF2N4O3Purezza:98%Colore e forma:SolidPeso molecolare:484.88KRAS G12C inhibitor 32
CAS:KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Formula:C29H30Cl3FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:635.94pan-KRAS-IN-4
CAS:Pan-KRAS-IN-4 (compound 5) is a potent KRAS inhibitor, demonstrating IC50 values of 0.37 nM for Kras G12C and 0.19 nM for Kras G12V [1].Formula:C36H34F2N6O3Purezza:98%Colore e forma:SolidPeso molecolare:636.69SOS1/KRAS-IN-1
CAS:SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Formula:C24H26F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:457.49ARS-1323
CAS:ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Formula:C21H17ClF2N4O2Purezza:99.53%Colore e forma:SolidPeso molecolare:430.84KRas G12C inhibitor 1
CAS:KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.Formula:C31H38N6O3Purezza:98%Colore e forma:SolidPeso molecolare:542.67BDP9066
CAS:BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formula:C20H24N6Purezza:98.18%Colore e forma:SolidPeso molecolare:348.44Pan-RAS-IN-1
CAS:Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Formula:C36H41Cl2F3N6O2Purezza:99.77%Colore e forma:SolidPeso molecolare:717.65PAT-IN-1
CAS:PAT-IN-1, a protein acyl transferases (PAT) inhibitor, competitively inhibits Erf2 autopalmitoylation (WO2017011518A1; compound 13) [1].Formula:C45H68N4OColore e forma:SolidPeso molecolare:681.05KRAS inhibitor-31
CAS:<p>KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.</p>Formula:C33H30F3N5O4Colore e forma:SolidPeso molecolare:617.62XMU-MP-9
CAS:XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of K-Ras. It enhances the interaction and induces conformational changes within the Nedd4-1/K-Ras complex. Furthermore, XMU-MP-9 facilitates the ubiquitination and degradation of various K-Ras mutants and inhibits the proliferation of cells with these mutants. This compound is useful in cancer research.Formula:C19H13ClFN3OSColore e forma:SolidPeso molecolare:385.84J-104871
CAS:<p>J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.</p>Formula:C38H32N2O12Purezza:98%Colore e forma:SolidPeso molecolare:708.67AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Formula:C24H16FN3OS2Colore e forma:SolidPeso molecolare:445.53KRAS inhibitor-37
CAS:KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.Formula:C32H33ClFN7O3Colore e forma:SolidPeso molecolare:618.10KRAS inhibitor-35
CAS:<p>KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.</p>Formula:C38H32F4N6O3SColore e forma:SolidPeso molecolare:728.76SOF-436
CAS:SOF-436 is a KRAS inhibitor that can suppress SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and inhibit the interaction between KRAS and the effector protein RAF. SOF-436 is applicable to cancer research.Formula:C15H13F2NO4S2Colore e forma:SolidPeso molecolare:373.395ZCL279
CAS:ZCL279 is a small molecule modulator (SMM) that inhibits the interaction between CDC42 and intersectin (ITSN). At lower concentrations (<10 μM), ZCL279 activates Cdc42, a cytoplasmic small GTPase in the Ras superfamily, while at higher concentrations (<10 μM) it significantly inhibits it.Formula:C24H18N2O7S2Colore e forma:SolidPeso molecolare:510.539Dorrigocin A
CAS:Dorrigocin A, an analog of Migrastatin, inhibits the carboxymethyltransferase involved in Ras processing, reversing the morphology of Ras-transformed NIH/3T3 cells. Dorrigocin A holds potential for research as an anticancer and anti-arthritis agent.Formula:C27H41NO8Colore e forma:SolidPeso molecolare:507.616KRAS G12D inhibitor 26
CAS:<p>KRAS G12D inhibitor 26 (Compound 64B) is an inhibitor of KRAS G12D with an IC50 ≤ 100 nM.</p>Formula:C35H44ClFN8O2Purezza:99.93%Colore e forma:SolidPeso molecolare:663.23KRAS inhibitor-32
CAS:KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formula:C29H35FN10OS2Colore e forma:SolidPeso molecolare:622.78
