ERK
ERK è una proteina chiave nella via di segnalazione MAPK (Mitogen-Activated Protein Kinase), coinvolta nella trasmissione dei segnali dai recettori di superficie cellulare al DNA nel nucleo della cellula. ERK svolge un ruolo cruciale nella regolazione di vari processi cellulari, tra cui la proliferazione, la differenziazione e la sopravvivenza. La disregolazione della segnalazione ERK è associata allo sviluppo del cancro e di altre malattie, rendendola un importante bersaglio per l'intervento terapeutico. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di ERK di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 202 prodotti di "ERK"
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MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:358.39ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurezza:99.89%Colore e forma:SoildPeso molecolare:337.8Methylthiouracil
CAS:Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.Formula:C5H6N2OSPurezza:99.89% - >99.99%Colore e forma:Crystals Saturated Aqueous Solution Is Neutral Or Slightly Acidic (Ntp 1992)Peso molecolare:142.18CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formula:C22H21F3N6O2Purezza:99.42%Colore e forma:SolidPeso molecolare:458.44(E/Z)-BCI
CAS:<p>(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS</p>Formula:C22H23NOPurezza:99.94%Colore e forma:SolidPeso molecolare:317.42Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurezza:99% - 99.99%Colore e forma:Off-White To Yellow SolidPeso molecolare:414.77Honokiol
CAS:Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.Formula:C18H18O2Purezza:99.65% - 99.94%Colore e forma:Dark Brown To White Fine Powder With Pleasant Odor Spicy And Slightly Bitter TastePeso molecolare:266.33Lidocaine Hydrochloride hydrate
CAS:<p>Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.</p>Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82Lidocaine
CAS:<p>Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.</p>Formula:C14H22N2OPurezza:99.95% - >99.99%Colore e forma:Needles From Benzene Or Alcohol SolidPeso molecolare:234.34AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formula:C32H40N8O5SPurezza:98.96%Colore e forma:SolidPeso molecolare:648.78ERK5-IN-6
CAS:<p>ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.</p>Formula:C23H21N3Purezza:98.59%Colore e forma:SoildPeso molecolare:339.43Urolithin B
CAS:Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormula:C13H8O3Purezza:99.45%Colore e forma:SolidPeso molecolare:212.2LUT014
CAS:<p>LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.</p>Formula:C27H19F3N8OPurezza:99.03%Colore e forma:SolidPeso molecolare:528.49Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formula:C14H23ClN2OPurezza:99.81% - 99.92%Colore e forma:White Crystal PowderPeso molecolare:270.798Mefloquine
CAS:<p>Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.</p>Formula:C17H16F6N2OPurezza:99.89%Colore e forma:SolidPeso molecolare:378.31MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purezza:97.3% - 99.07%Colore e forma:SolidPeso molecolare:565.71Firazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Formula:C22H25F3N2O4SColore e forma:SolidPeso molecolare:470.51KRAS G12C inhibitor 69
<p>KRAS G12C inhibitor 69 (Compound K09) is an inhibitor of the mutant RAS protein KRAS G12C with an IC50 of 4.36 nM. In the cell lines NCI-H358 and MIA-PACA-2, it suppresses ERK phosphorylation with IC50 values of 12 nM and 7 nM, respectively. Additionally, KRAS G12C inhibitor 69 hinders the proliferation of NCI-H358 and MIA-PACA-2 cancer cells, with IC50 values of 3.15 nM and 2.33 nM, respectively.</p>Formula:C29H29ClF3N5O3Colore e forma:SolidPeso molecolare:588.02MHJ-627
<p>MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading</p>Formula:C34H45BrN2O3Purezza:98%Colore e forma:SolidPeso molecolare:609.64PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Colore e forma:Odour SolidPROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purezza:98%Colore e forma:SolidPeso molecolare:1201.17STE-MEK1(13)
CAS:<p>STE-MEK1(13), a cell-permeable ERK1/2 inhibitor with IC50 values ranging from 13 to 30 μM, impedes the phosphorylation of ERK1/2, as demonstrated in studies [1</p>Formula:C86H153N19O17SPurezza:98%Colore e forma:SolidPeso molecolare:1757.32Endothelin-1 (1-31) (Human) TFA
Endothelin-1 (1-31) (Human) TFA, a potent vasoconstrictor and hypertensive agent, originates from the chymase-mediated selective hydrolysis of big ET-1 [1].Formula:C164H237F3N38O49S5Purezza:98%Colore e forma:SolidPeso molecolare:3742.18VSLRGDTRG
CAS:VSLRGDTRG is a synthetic peptide derived from the RGD motif in cadherin17 (CDH17) that binds to the α2β1 integrin, activating its signaling pathways. By promoting high-affinity conformational changes in β1 integrins through the RGD motif, VSLRGDTRG enhances cell adhesion and the phosphorylation of FAK and ERK1/2, thereby driving tumor proliferation and metastasis. This peptide is useful for research on cancers expressing CDH17, such as colorectal and pancreatic cancer.Formula:C38H69N15O14Colore e forma:SolidPeso molecolare:960.047Rineterkib hydrochloride
CAS:Rineterkib hydrochloride (B) is an oral RAF/ERK1/2 inhibitor for MAPK-driven cancers, including KRAS/BRAF-mutant NSCLC and CRC.Formula:C26H28BrClF3N5O2Colore e forma:SolidPeso molecolare:614.89LC-SF-14
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.Formula:C44H50Cl3N13O5SColore e forma:SolidPeso molecolare:977.28442PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:476.23GSK143
CAS:GSK143: Oral SYK inhibitor, pIC50=7.5, curbs pErk, anti-inflammatory, hinders immune cells in mice.Formula:C17H22N6O2Colore e forma:SolidPeso molecolare:342.403A-674563 HCl (552325-73-2(free base))
CAS:<p>A-674563: Oral Akt inhibitor (Ki: 11 nM for Akt1), also targets PKA/Cdk2, with 10-1800x selectivity over other kinases.</p>Formula:C22H23ClN4OPurezza:≥98%Colore e forma:SolidPeso molecolare:394.9Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Formula:C19H30O3Colore e forma:SolidPeso molecolare:306.44Astragaloside
CAS:Astragaloside, one of the main active ingredients in Astragalus membranaceus.Formula:C28H32O17Purezza:99.9%Colore e forma:Odour SolidPeso molecolare:640.544′-Demethylnobiletin
CAS:<p>4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and</p>Formula:C20H20O8Colore e forma:SolidPeso molecolare:388.37Edaxeterkib
CAS:Edaxeterkib is a potent extracellular signal- regulated kinase (ERK) inhibitor for the research of cancer.Formula:C26H27N7O2Colore e forma:SolidPeso molecolare:469.549Olomoucine
CAS:<p>Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.</p>Formula:C15H18N6OPurezza:99.77%Colore e forma:White Crystalline PowderPeso molecolare:298.34TRV055
CAS:TRV055: Gq-biased AT1R ligand, stimulates Gq signaling, aids Gq-biased agonist development.Formula:C42H57N9O9Peso molecolare:831.972Emodic acid
CAS:Emodic acid is a useful organic compound for research related to life sciences. The catalog number is T124807 and the CAS number is 478-45-5.Formula:C15H8O7Colore e forma:SolidPeso molecolare:300.222HDAC6-IN-61
HDAC6-IN-61 (Compound 4e) is an HDAC6 inhibitor with an IC50 of 73 nM, demonstrating greater selectivity compared to other HDAC isomers. It also acts as an activator of GPR40. HDAC6-IN-61 can increase the acetylation of tubulin and phosphorylation levels of ERK. This compound is relevant for studying neuroinflammation, including Alzheimer's disease.Colore e forma:Odour SolidROCK-IN-5
CAS:<p>ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.</p>Formula:C16H11ClFN3OSPurezza:99.72% - 99.83%Colore e forma:SolidPeso molecolare:347.79ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Formula:C28H31ClFN5O6SColore e forma:SolidPeso molecolare:620.09Laxiflorin B-4
<p>Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].</p>Purezza:98%Colore e forma:Odour SolidBTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Formula:C50H57F4N9O5Colore e forma:SolidPeso molecolare:940.04TAT-DEF-Elk-1
CAS:TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.Formula:C155H259N57O40Purezza:98%Colore e forma:SolidPeso molecolare:3561.136Anti-inflammatory agent 35
CAS:Anti-inflammatory agent 35 is a potent anti-inflammatory agent.Formula:C27H29NO8Purezza:99.98%Colore e forma:SoildPeso molecolare:495.52VSLRGDTRG acetate
<p>VSLRGDTRG acetate is a synthetic peptide of the RGD motif from cadherin17 (CDH17), capable of binding to α2β1 integrin and activating its signaling pathways. It facilitates the high-affinity conformational change of β1 integrin via the RGD motif, enhancing cell adhesion and phosphorylation of FAK and ERK1/2, thereby promoting tumor proliferation and metastasis. VSLRGDTRG acetate is applicable in research on cancers expressing CDH17, such as colon and pancreatic cancers.</p>Colore e forma:Odour SolidKinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Colore e forma:Odour SolidMK2-IN-5
CAS:<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Formula:C61H113N21O16Purezza:98%Colore e forma:SolidPeso molecolare:1396.68SOS1-IN-18
<p>SOS1-IN-18 (Compound 8) is an inhibitor of the Son of Sevenless 1 protein (SOS1) with a dissociation constant (KD) of 2.6 nM. It disrupts the SOS1-KRAS G12C interaction with an IC50 of 3.4 nM, inhibits ERK phosphorylation in H358 cells with an IC50 of 31 nM, and curtails the proliferation of H358 cells with an IC50 of 5 nM.</p>Formula:C26H29F3N4O2Colore e forma:SolidPeso molecolare:486.53PPM-3
<p>PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.</p>Formula:C54H69N11O6SPurezza:98%Colore e forma:SolidPeso molecolare:1000.26SCH772984 HCl
SCH772984 HCl selectively inhibits ERK1/2, acts like type I/II kinase inhibitors, and is potent at 4/1 nM IC50s in certain mutated tumor cells.Formula:C33H34ClN9O2Purezza:98%Colore e forma:SolidPeso molecolare:624.14MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidCHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Formula:C8H9Cl2NO3Purezza:99.57%Colore e forma:SoildPeso molecolare:238.07Fulipiftide
CAS:<p>Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.</p>Formula:C144H227N41O47Colore e forma:SolidPeso molecolare:3284.594-P-PDOT
CAS:<p>4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.</p>Formula:C19H21NOPurezza:99.91%Colore e forma:SolidPeso molecolare:279.38EPHB2 Protein, Cynomolgus, Recombinant (His)
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.Colore e forma:Lyophilized PowderPeso molecolare:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormula:C29H27F3N2O2Purezza:99.71%Colore e forma:SolidPeso molecolare:492.53EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formula:C14H18ClN3O3Purezza:97.55%Colore e forma:SolidPeso molecolare:311.76PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Formula:C23H18F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:437.42EphB2 Protein, Mouse, Recombinant (His)
EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Colore e forma:Lyophilized PowderPeso molecolare:75.2 kDa (predicted); 65 kDa (reducing conditions)ERK2 Protein, Human, Recombinant (GST)
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Colore e forma:Lyophilized PowderPeso molecolare:67 kDa (predicted); 67 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)TRPM4 inhibitor 8
CAS:<p>TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.</p>Formula:C11H17BrN2Purezza:97%Colore e forma:SolidPeso molecolare:257.17ERK2 Protein, Mouse, Recombinant (His & GST)
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Colore e forma:Lyophilized PowderPeso molecolare:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:84.6 kDa (predicted); 96.6 kDa (reducing conditions)SBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Formula:C27H35ClN4O2Purezza:99.42%Peso molecolare:483.05Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Formula:C23H16NaO6Purezza:99.73%Colore e forma:Yellow PowderPeso molecolare:411.36EphB2 Protein, Human, Recombinant (His & hFc)
<p>EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.</p>Colore e forma:Lyophilized PowderPeso molecolare:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)LM22B-10
CAS:<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formula:C27H33ClN2O4Purezza:98.18%Colore e forma:SolidPeso molecolare:485.01Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purezza:97.02% - 99.94%Colore e forma:White PowderPeso molecolare:434.35Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Formula:C22H26N2O4Purezza:98.61% - 99.94%Colore e forma:SolidPeso molecolare:382.45Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SoildPeso molecolare:390.07VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purezza:98.92% - ≥98%Colore e forma:SolidPeso molecolare:500.35HS-1793
CAS:<p>HS-1793, resveratrol-like, reduces HIF-1, VEGF in hypoxia, and curbs human breast cancer growth in mouse model.</p>Formula:C16H12O3Purezza:98.16% - 99.82%Colore e forma:SolidPeso molecolare:252.26ERK1/2 inhibitor 2
CAS:<p>ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable ERK 1/2 inhibitor, with potential antineoplastic activity.</p>Formula:C29H31ClFN5O5Purezza:98.99%Colore e forma:SolidPeso molecolare:584.04Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purezza:99% - 99.84%Colore e forma:Hydroscopic Brown Or Yellow PowderPeso molecolare:784.97magnolin
CAS:<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Formula:C23H28O7Purezza:98% - 99.77%Colore e forma:SolidPeso molecolare:416.46Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purezza:99.42% - 99.65%Colore e forma:SolidPeso molecolare:801.01Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33SEW2871
CAS:SEW 2871 is an orally available, highly selective S1P1 agonist. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.Formula:C20H10F6N2OSPurezza:99.96%Colore e forma:White SolidPeso molecolare:440.36BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purezza:97.84%Colore e forma:SolidPeso molecolare:440.54PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purezza:98.63% - >99.99%Colore e forma:Yellow SolidPeso molecolare:267.28Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purezza:97.03% - 99.90%Colore e forma:SolidPeso molecolare:317.34TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purezza:99.17% - 99.53%Colore e forma:White Solid PowderPeso molecolare:166.22SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C33H33N9O2Purezza:97.565% - 98.75%Colore e forma:SolidPeso molecolare:587.67Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formula:C25H26N6O2Purezza:99.67%Colore e forma:SolidPeso molecolare:442.51Periplocin
CAS:<p>Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.</p>Formula:C36H56O13Purezza:99.66% - 99.74%Colore e forma:SolidPeso molecolare:696.82SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formula:C15H8Cl2FN3OPurezza:99.56%Colore e forma:SolidPeso molecolare:336.15Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Formula:C13H8Cl2N4S2Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:355.27ERK5-IN-2
CAS:<p>ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.</p>Formula:C17H11BrFN3O2Purezza:99.01%Colore e forma:SolidPeso molecolare:388.19Asperulosidic acid
CAS:Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formula:C18H24O12Purezza:99.47%Colore e forma:SolidPeso molecolare:432.38CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Formula:C20H28O3Purezza:97.06% - 99.08%Colore e forma:SolidPeso molecolare:316.43Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formula:C6H9NOS2Purezza:97.55% - 99.67%Colore e forma:Slightly Yellowish LiquidPeso molecolare:175.27Acalabrutinib
CAS:Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formula:C26H23N7O2Purezza:98.94% - 99.64%Colore e forma:SolidPeso molecolare:465.51XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Formula:C26H30N6O3Purezza:98.21%Colore e forma:SolidPeso molecolare:474.55Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Formula:C20H22O6Purezza:99.11% - 99.64%Colore e forma:White Crystalline PowderPeso molecolare:358.39Peramivir Trihydrate
CAS:<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Formula:C15H28N4O4·3H2OPurezza:99.52% - ≥95%Colore e forma:SolidPeso molecolare:382.45Ulixertinib
CAS:<p>Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.</p>Formula:C21H22Cl2N4O2Purezza:99.31% - 99.95%Colore e forma:SolidPeso molecolare:433.33N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurezza:99.46% - 99.84%Colore e forma:SolidPeso molecolare:177.24(E/Z)-BIX 02189
CAS:(E/Z)-BIX 02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formula:C27H28N4O2Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:440.54Pluripotin
CAS:Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) andFormula:C27H25F3N8O2Purezza:98.77% - 98.82%Colore e forma:SolidPeso molecolare:550.53Tenuifoliside A
CAS:Tenuifoliside A has anti-apoptotic , neuroprotective activity.Formula:C31H38O17Purezza:98.99% - 99.91%Colore e forma:SolidPeso molecolare:682.62BAY885
CAS:<p>BAY885 is a new ERK5 inhibitor.</p>Formula:C25H28F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:515.53Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purezza:99.85% - 99.90%Colore e forma:SolidPeso molecolare:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formula:C22H27N7O2SPurezza:99.57% - >99.99%Colore e forma:SolidPeso molecolare:453.56ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purezza:97.70%Colore e forma:SolidPeso molecolare:459.54Tauroursodeoxycholate
CAS:Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.Formula:C26H45NO6SPurezza:98.77% - 99.93%Colore e forma:White SolidPeso molecolare:499.7Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:316.35UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Formula:C26H28N4O3Purezza:99.3% - 99.53%Colore e forma:SolidPeso molecolare:444.532,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purezza:99.75%Colore e forma:Yellow PowderPeso molecolare:152.15Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purezza:98.76% - >99.99%Colore e forma:SolidPeso molecolare:272.25Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purezza:99.43% - >99.99%Colore e forma:White PowderPeso molecolare:528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS:<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Formula:C56H81N13O14Purezza:99.91%Colore e forma:SolidPeso molecolare:1160.34GRK5-IN-2
CAS:GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.Formula:C20H20N4O4Purezza:99.92%Colore e forma:SolidPeso molecolare:380.46-OAU
CAS:6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.Formula:C12H21N3O2Purezza:98.14% - 99.01%Colore e forma:SolidPeso molecolare:239.31Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formula:C36H46N8O3Purezza:98.75% - 99.7%Colore e forma:SolidPeso molecolare:638.8DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Formula:C26H28F3N7O2Purezza:98.55% - 99.28%Colore e forma:SolidPeso molecolare:527.54AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Formula:C10H5N3O3Purezza:97.35%Colore e forma:SolidPeso molecolare:215.16ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purezza:99.71%Colore e forma:SolidPeso molecolare:747.85Epieriocalyxin A
CAS:<p>Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.</p>Formula:C20H24O5Purezza:97.00%Colore e forma:SolidPeso molecolare:344.4DMU-212
CAS:<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Formula:C18H20O4Purezza:99.86%Colore e forma:SolidPeso molecolare:300.35SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purezza:99.36%Colore e forma:SolidPeso molecolare:451.6RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurezza:98.87%Colore e forma:SolidPeso molecolare:480.46ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formula:C22H25ClFN7O2Purezza:99.55% - 99.76%Colore e forma:SolidPeso molecolare:473.93Methylnissolin
CAS:<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Formula:C17H16O5Purezza:99.68% - 99.98%Colore e forma:SolidPeso molecolare:300.31EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurezza:99.71%Colore e forma:SolidPeso molecolare:311.33Deltonin
CAS:Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formula:C45H72O17Purezza:98.77% - 99.79%Colore e forma:SolidPeso molecolare:885.04trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurezza:97.13% - 98.96%Colore e forma:White To Light Yellow Crystal PowderPeso molecolare:219.24Ravoxertinib
CAS:<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Formula:C21H18ClFN6O2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:440.86Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurezza:99.09% - 99.53%Colore e forma:SolidPeso molecolare:340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Formula:C71H114N16O28Purezza:95.29%Colore e forma:SolidPeso molecolare:1639.76Tauroursodeoxycholate sodium
CAS:Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.Formula:C26H44NNaO6SPurezza:97.90%Colore e forma:SolidPeso molecolare:521.69FR 180204
CAS:<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Formula:C18H13N7Purezza:98% - 99.74%Colore e forma:SolidPeso molecolare:327.34MRTX1133
CAS:<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Formula:C33H31F3N6O2Purezza:97.39% - 99.6%Colore e forma:SolidPeso molecolare:600.63KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formula:C21H17N5OPurezza:97.84%Colore e forma:SolidPeso molecolare:355.39AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72%Colore e forma:SolidPeso molecolare:461.23(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Formula:C25H24N4O2Purezza:97.39% - 98.38%Colore e forma:SolidPeso molecolare:412.48Tizaterkib
CAS:Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.Formula:C24H24F2N8O2Purezza:99.6% - 99.63%Colore e forma:SolidPeso molecolare:494.5ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formula:C14H17ClN2O3SPurezza:98.92% - 99.84%Colore e forma:SolidPeso molecolare:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:469.79PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Formula:C22H16F2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:406.38CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Formula:C22H17Cl2FN4O2Colore e forma:SolidPeso molecolare:459.3BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19ERK5-IN-3
CAS:<p>ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).</p>Formula:C24H23Cl2FN4O2Colore e forma:SolidPeso molecolare:489.37Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formula:C8H16O2S2Purezza:97.51%Colore e forma:Yellow To Orange LiquidPeso molecolare:208.34GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColore e forma:SolidPeso molecolare:462.47Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColore e forma:SolidPeso molecolare:276.13mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purezza:99.26%Colore e forma:SolidPeso molecolare:1948.312,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Formula:C12H10O2Purezza:99.66%Colore e forma:White To Grey-Brownish PowderPeso molecolare:186.21PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColore e forma:SolidPeso molecolare:296.11D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.4ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formula:C29H32ClN5O4Purezza:98.81%Colore e forma:SolidPeso molecolare:550.05UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Colore e forma:SolidPeso molecolare:403.9Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColore e forma:SolidPeso molecolare:456.89ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Colore e forma:SolidPeso molecolare:505.44GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purezza:98%Colore e forma:SolidPeso molecolare:304.38(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purezza:98.09%Colore e forma:SolidPeso molecolare:304.38NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purezza:99.75%Colore e forma:SolidPeso molecolare:330.092ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purezza:99.71% - 99.95%Colore e forma:SolidPeso molecolare:344.37RLX-33
CAS:<p>RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.</p>Formula:C24H19ClN4O4Purezza:99.89%Colore e forma:SolidPeso molecolare:462.89EVT801
CAS:EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formula:C19H21N5O3Purezza:97.4%Colore e forma:SolidPeso molecolare:367.4Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Formula:C20H24O5Purezza:98%Colore e forma:SolidPeso molecolare:344.4ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formula:C28H32ClFN6O5Colore e forma:SolidPeso molecolare:587.04ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purezza:98%Colore e forma:SolidPeso molecolare:586.08ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Formula:C18H12N6OColore e forma:SolidPeso molecolare:328.33MRS2693 trisodium
CAS:MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].Formula:C9H10IN2Na3O12P2Colore e forma:SolidPeso molecolare:596MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFormula:C18H20FN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:393.43KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purezza:98%Colore e forma:SolidPeso molecolare:590.09ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Formula:C23H20ClN7O2SColore e forma:SolidPeso molecolare:493.97(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purezza:98.73%Colore e forma:SolidPeso molecolare:500.35Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Formula:C21H19N3O4Purezza:97.36% - 99.88%Colore e forma:SolidPeso molecolare:377.39DL-threo dihydrosphingosine
CAS:DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.Formula:C18H39NO2Colore e forma:SolidPeso molecolare:301.51I-287
CAS:I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.Formula:C30H30ClFN4O4Colore e forma:SolidPeso molecolare:565.04K145 hydrochloride
CAS:<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Formula:C18H25ClN2O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:384.92CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purezza:98%Colore e forma:SolidPeso molecolare:1310.37SKI2496
CAS:SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formula:C35H36F7N5O5Colore e forma:SolidPeso molecolare:739.68Firazorexton hydrate
CAS:Firazorexton hydrate (TAK-994) is a brain-penetrant and orally active agonist of the orexin type 2 receptor (OX2R) with a potent EC50 of 19 nM.Formula:C22H25F3N2O4SH2OColore e forma:SolidPeso molecolare:497.53ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formula:C23H22FN7OSColore e forma:SolidPeso molecolare:463.53MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formula:C37H41N9O3SPurezza:96.15% - 97.19%Colore e forma:SolidPeso molecolare:691.84AL 8810
CAS:AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Formula:C24H31FO4Colore e forma:SolidPeso molecolare:402.5Hypothemycin
CAS:Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.Formula:C19H22O8Purezza:98%Colore e forma:SolidPeso molecolare:378.37ERK2 IN-1
CAS:<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Formula:C36H34FN7O2SPurezza:98%Colore e forma:SolidPeso molecolare:647.76KRAS inhibitor-27
CAS:<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Formula:C31H28ClF3N6O3SColore e forma:SolidPeso molecolare:657.106DOR agonist 2
CAS:Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formula:C29H26N2O3Colore e forma:SolidPeso molecolare:450.53(rel)-AR234960
CAS:(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formula:C27H30FN5O5SColore e forma:SolidPeso molecolare:555.63MAP855
CAS:MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Formula:C28H23ClF2N6O3Colore e forma:SolidPeso molecolare:564.97SHR2415
SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.Formula:C23H22ClN7O2Colore e forma:SolidPeso molecolare:463.92ERK1/2 inhibitor 6
CAS:ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.Formula:C27H29ClFN7O5Colore e forma:SolidPeso molecolare:586.01SOS1 activator 2
CAS:<p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>Formula:C26H28ClFN6Colore e forma:SolidPeso molecolare:478.992KRASG12C IN-15
CAS:<p>KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.</p>Formula:C31H32FN3O2Colore e forma:SolidPeso molecolare:497.603ERK-IN-2
CAS:ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].Formula:C16H18ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:347.80ATX inhibitor 26
CAS:ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.Formula:C18H19Cl2N7O3Colore e forma:SolidPeso molecolare:452.30KU004
CAS:<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Formula:C29H27ClFN4O2PColore e forma:SolidPeso molecolare:548.98Rineterkib
CAS:Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.Formula:C26H27BrF3N5O2Purezza:99.73%Colore e forma:SolidPeso molecolare:578.42Omtriptolide
CAS:Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.Formula:C24H28O9Purezza:98%Colore e forma:SolidPeso molecolare:460.479Ravoxertinib hydrochloride
CAS:<p>Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).</p>Formula:C21H19Cl2FN6O2Purezza:98%Colore e forma:SolidPeso molecolare:477.32
