ERK
ERK è una proteina chiave nella via di segnalazione MAPK (Mitogen-Activated Protein Kinase), coinvolta nella trasmissione dei segnali dai recettori di superficie cellulare al DNA nel nucleo della cellula. ERK svolge un ruolo cruciale nella regolazione di vari processi cellulari, tra cui la proliferazione, la differenziazione e la sopravvivenza. La disregolazione della segnalazione ERK è associata allo sviluppo del cancro e di altre malattie, rendendola un importante bersaglio per l'intervento terapeutico. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di ERK di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 205 prodotti di "ERK"
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A-674563 HCl (552325-73-2(free base))
CAS:<p>A-674563: Oral Akt inhibitor (Ki: 11 nM for Akt1), also targets PKA/Cdk2, with 10-1800x selectivity over other kinases.</p>Formula:C22H23ClN4OPurezza:≥98%Colore e forma:SolidPeso molecolare:394.9TAT-DEF-Elk-1
CAS:TAT-DEF-Elk-1 is a cell-penetrating peptide Elk-1 inhibitor.Formula:C155H259N57O40Purezza:98%Colore e forma:SolidPeso molecolare:3561.136CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Formula:C8H9Cl2NO3Purezza:99.57%Colore e forma:SoildPeso molecolare:238.07Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Formula:C23H16NaO6Purezza:99.73%Colore e forma:Yellow PowderPeso molecolare:411.36GPR34 receptor antagonist 3
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner,Colore e forma:Odour SolidERK2 Protein, Human, Recombinant (GST)
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Colore e forma:Lyophilized PowderPeso molecolare:67 kDa (predicted); 67 kDa (reducing conditions)EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Formula:C14H18ClN3O3Purezza:97.55%Colore e forma:SolidPeso molecolare:311.76SBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Formula:C27H35ClN4O2Purezza:99.42%Peso molecolare:483.05EPHB2 Protein, Cynomolgus, Recombinant (His)
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression.Colore e forma:Lyophilized PowderPeso molecolare:59.09 kDa (predicted). Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.ERK2 Protein, Mouse, Recombinant (His & GST)
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Colore e forma:Lyophilized PowderPeso molecolare:69.1 kDa (predicted); 60 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag.Colore e forma:Lyophilized PowderPeso molecolare:75.2 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (hFc)
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:84.6 kDa (predicted); 96.6 kDa (reducing conditions)EphB2 Protein, Mouse, Recombinant (His)
EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:59.3 kDa (predicted); 65 kDa (reducing conditions)EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)EphB2 Protein, Human, Recombinant (His & hFc)
EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:86 kDa (predicted); 90-100 kDa (reducing condition, due to glycosylation)ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFormula:C29H27F3N2O2Purezza:99.71%Colore e forma:SolidPeso molecolare:492.53TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Formula:C11H17BrN2Purezza:99.84%Colore e forma:SolidPeso molecolare:257.17PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Formula:C23H18F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:437.42N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurezza:99.46% - 99.84%Colore e forma:SolidPeso molecolare:177.24Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Formula:C16H16F3N5Purezza:99.97%Colore e forma:SolidPeso molecolare:335.33SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purezza:99.36%Colore e forma:SolidPeso molecolare:451.6Corynoxeine
CAS:Corynoxeine inhibits ERK1/2, curbs VSMC growth induced by PDGF-BB, and may prevent vascular diseases and restenosis post-angioplasty.Formula:C22H26N2O4Purezza:98.61% - 99.94%Colore e forma:SolidPeso molecolare:382.45Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purezza:99.66% - 99.74%Colore e forma:SolidPeso molecolare:696.82Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purezza:99.42% - 99.65%Colore e forma:SolidPeso molecolare:801.01DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Formula:C26H28F3N7O2Purezza:98.55% - 99.28%Colore e forma:SolidPeso molecolare:527.54Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Formula:C25H26N6O2Purezza:99.67%Colore e forma:SolidPeso molecolare:442.51SCH772984
CAS:<p>SCH772984 is an ERK inhibitor and is highly selective and ATP-competitive. SCH772984 exhibits antitumor activity. Cost-effective and quality-assured.</p>Formula:C33H33N9O2Purezza:97.565% - 98.75%Colore e forma:SolidPeso molecolare:587.67VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purezza:98.92% - ≥98%Colore e forma:SolidPeso molecolare:500.35magnolin
CAS:<p>Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.</p>Formula:C23H28O7Purezza:98% - 99.77%Colore e forma:SolidPeso molecolare:416.46Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Formula:C21H22Cl2N4O2Purezza:99.31% - 99.95%Colore e forma:SolidPeso molecolare:433.33AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72%Colore e forma:SolidPeso molecolare:461.23ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purezza:97.70%Colore e forma:SolidPeso molecolare:459.54Peramivir Trihydrate
CAS:<p>Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles are</p>Formula:C15H28N4O4·3H2OPurezza:99.52% - ≥95%Colore e forma:SolidPeso molecolare:382.45TBHQ
CAS:TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.Formula:C10H14O2Purezza:99.17% - 99.53%Colore e forma:White Solid PowderPeso molecolare:166.22Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purezza:99.43% - >99.99%Colore e forma:White PowderPeso molecolare:528.76Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Formula:C20H22O6Purezza:99.11% - 99.64%Colore e forma:White Crystalline PowderPeso molecolare:358.39Piperlongumine
CAS:Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L.Formula:C17H19NO5Purezza:97.03% - 99.90%Colore e forma:SolidPeso molecolare:317.34DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Formula:C26H28N4O3Purezza:99.3% - 99.53%Colore e forma:SolidPeso molecolare:444.53Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SoildPeso molecolare:390.07BAY885
CAS:BAY885 is a new ERK5 inhibitor.Formula:C25H28F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:515.53XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Formula:C26H30N6O3Purezza:98.21%Colore e forma:SolidPeso molecolare:474.55Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purezza:97.00%Colore e forma:SolidPeso molecolare:344.4Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purezza:99.85% - 99.90%Colore e forma:SolidPeso molecolare:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formula:C22H27N7O2SPurezza:99.57% - >99.99%Colore e forma:SolidPeso molecolare:453.566-OAU
CAS:6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.Formula:C12H21N3O2Purezza:98.14% - 99.01%Colore e forma:SolidPeso molecolare:239.31Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Formula:C20H18O11Purezza:97.02% - 99.94%Colore e forma:White PowderPeso molecolare:434.35Astragaloside IV
CAS:Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formula:C41H68O14Purezza:99% - 99.84%Colore e forma:Hydroscopic Brown Or Yellow PowderPeso molecolare:784.97Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purezza:99.71%Colore e forma:SolidPeso molecolare:747.85UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5
