Canale TRP/TRPV
canali TRP (Transient Receptor Potential), inclusa la sottofamiglia TRPV, sono un gruppo di canali ionici coinvolti in vari processi sensoriali, come la percezione della temperatura, la sensazione del dolore e l'osmoregolazione. I canali TRP sono ampiamente espressi in diversi tessuti e svolgono un ruolo nelle risposte fisiologiche agli stimoli ambientali. In particolare, i canali TRPV sono coinvolti nel rilevamento dei cambiamenti di temperatura e sono implicati in condizioni come il dolore cronico, l'infiammazione e il cancro. Presso CymitQuimica, offriamo una gamma completa di modulatori dei canali TRP/TRPV per supportare la tua ricerca in biologia sensoriale, gestione del dolore e trasduzione del segnale.
Trovati 110 prodotti per "Canale TRP/TRPV".
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AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Formula:C19H17F6N3OPurezza:99.84%Colore e forma:SolidPeso molecolare:417.35Ref: TM-T10300
1mg71,00€5mg161,00€1mL*10mM (DMSO)172,00€10mg235,00€25mg423,00€50mg627,00€100mg803,00€IAA65
CAS:IAA65 is a potent selective TRPA1 inhibitor; IC50 4.3 nM; blocks calcium influx; analgesic; used for inflammatory and neuropathic pain research.Formula:C16H13F6NO2Purezza:97.46%Colore e forma:SolidPeso molecolare:365.27TRPV1 agonist-1
CAS:TRPV1 agonist-1 (Compound 13) is a non-irritant TRPV1 agonist that is effective when administered orally. It shows EC50 values of 4.5 nM for humans and 0.57 nM for rats. TRPV1 agonist-1 has the capability to improve swallowing function in rats and is applicable for research on dysphagia.Formula:C28H35NO5Peso molecolare:465.58TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Formula:C24H20F6N5Na2O7PSPurezza:98%Colore e forma:SolidPeso molecolare:713.45ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Formula:C10H11Cl2NOColore e forma:SolidPeso molecolare:232.106ZA18
CAS:ZA18 is a selective TRPM2 channel inhibitor with an IC50 value of 6.2 μM. It effectively suppresses intracellular Ca2+ overload triggered by TRPM2 channel activation and significantly reduces H2O2-induced cell death in SH-SY5Y cells. ZA18 is applicable for research on ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases.Formula:C29H30N4OPeso molecolare:450.59TRPC3 agonist-1
CAS:TRPC3 agonist-1 (compound 4n) is a selective competitive activator of the TRPC3 channel, binding specifically to the L2 site of hTRPC3.Formula:C22H23F3N4O3Peso molecolare:448.45LY3526318
CAS:LY3526318 is an orally active, selective TRPA1 antagonist with an IC50 of 5-6 μM. It blocks the TRPA1 channel, inhibiting pain signal transduction mediated by this channel and demonstrating analgesic activity. LY3526318 is primarily utilized in research related to chronic pain, such as diabetic peripheral neuropathic pain, chronic lower back pain, and osteoarthritis-induced pain.Formula:C23H19F3N10O4Peso molecolare:556.46TRPM5 agonist-1
CAS:TRPM5 agonist-1 is an orally active TRPM5 agonist with a pEC50 value of 8.1. It displays excellent selectivity for related cation channels (TRPM8, TRPV1, TRPV4, TRPA1, TRPM4) with selectivity greater than 100-fold. TRPM5 agonist-1 induces local stimulation of gastrointestinal transit in mice and is useful for studying the promotion of gastric motility.Formula:C11H7Cl2N3S2Peso molecolare:316.22GSK2220691
CAS:SK2220691 is a potent TRPV4 inhibitor. It effectively suppresses pulmonary edema induced by GSK1016790. Additionally, SK2220691 inhibits the increase of crucial factors such as VEGF, keratinocyte-derived chemokine (KC; CXCL1), and granulocyte colony-stimulating factor (GCSF) induced by hydrochloric acid.Formula:C32H33N5O3Peso molecolare:535.64
