Canale TRP/TRPV
canali TRP (Transient Receptor Potential), inclusa la sottofamiglia TRPV, sono un gruppo di canali ionici coinvolti in vari processi sensoriali, come la percezione della temperatura, la sensazione del dolore e l'osmoregolazione. I canali TRP sono ampiamente espressi in diversi tessuti e svolgono un ruolo nelle risposte fisiologiche agli stimoli ambientali. In particolare, i canali TRPV sono coinvolti nel rilevamento dei cambiamenti di temperatura e sono implicati in condizioni come il dolore cronico, l'infiammazione e il cancro. Presso CymitQuimica, offriamo una gamma completa di modulatori dei canali TRP/TRPV per supportare la tua ricerca in biologia sensoriale, gestione del dolore e trasduzione del segnale.
Trovati 96 prodotti di "Canale TRP/TRPV"
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Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Formula:C16H11Cl3F3N3O3Purezza:98.04%Colore e forma:SolidPeso molecolare:456.63Ref: TM-T16687
1mg35,00€2mg52,00€5mg77,00€10mg97,00€25mg215,00€50mg363,00€100mg512,00€200mg738,00€500mg1.121,00€1mL*10mM (DMSO)86,00€Mavatrep
CAS:Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain.Formula:C25H21F3N2OPurezza:98.51% - 99.31%Colore e forma:SolidPeso molecolare:422.44Ref: TM-T16014
1mg66,00€2mgPrezzo su richiesta5mg144,00€10mg227,00€25mg406,00€50mg652,00€100mg938,00€200mg1.311,00€1mL*10mM (DMSO)159,00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Formula:C17H17N3O2SPurezza:99.9%Colore e forma:SolidPeso molecolare:327.4Ref: TM-T27308
1mg35,00€5mg78,00€10mg116,00€25mg190,00€50mg269,00€100mg383,00€200mg525,00€1mL*10mM (DMSO)88,00€SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
Formula:C17H21F3N4O2SPurezza:99.77%Colore e forma:SolidPeso molecolare:402.43MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Formula:C27H31FN6O2Purezza:98.83% - 99.44%Colore e forma:SolidPeso molecolare:490.57Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Formula:C18H16ClF3N2OSPurezza:99.66%Colore e forma:SolidPeso molecolare:400.85GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Formula:C20H15F4N3O5SPurezza:98%Colore e forma:SolidPeso molecolare:485.41PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Formula:C26H21FN2O3Purezza:99.84%Colore e forma:SolidPeso molecolare:428.45Ref: TM-T16483
1mg47,00€2mg60,00€5mg87,00€10mg145,00€25mg279,00€50mg425,00€100mg645,00€200mg895,00€1mL*10mM (DMSO)96,00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Formula:C16H19ClN2O3SPurezza:99.75%Colore e forma:SolidPeso molecolare:354.85A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Formula:C22H20ClF2N3O2Colore e forma:SolidPeso molecolare:431.86AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Formula:C24H26F3N3O2Purezza:99.93%Colore e forma:SolidPeso molecolare:445.48Ref: TM-T29968
1mg215,00€5mg523,00€10mg695,00€25mg1.054,00€50mg1.414,00€100mg1.900,00€200mg2.565,00€1mL*10mM (DMSO)537,00€AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Formula:C19H17F6N3OPurezza:99.84%Colore e forma:SolidPeso molecolare:417.35Ref: TM-T10300
1mg74,00€5mg170,00€10mg248,00€25mg445,00€50mg662,00€100mg848,00€1mL*10mM (DMSO)182,00€ELP-004
CAS:ELP-004 is a TRPC channel inhibitor that blocks Ca2+ entry mediated by TRPC channels. It serves as an osteoclast inhibitor by preventing osteoclast differentiation. ELP-004 also hinders basal Ca2+ levels and the associated translocation of NFATc1 in inflammatory osteoclastogenesis. Additionally, it reduces bone erosion in mouse models of rheumatoid arthritis.Formula:C10H11Cl2NOPeso molecolare:232.106TRPA1 Antagonist 1
CAS:TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.Formula:C24H20F6N5Na2O7PSPurezza:98%Colore e forma:SolidPeso molecolare:713.45Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].
Formula:C10H15Cl4N5O2Purezza:99.30%Colore e forma:SolidPeso molecolare:379.07Motugivatrep
CAS:Motugivatrep is a potent and selective TRPV1 antagonist that can be used to study TRPV1-related respiratory diseases.
Formula:C22H20F3NO3Purezza:99.22%Colore e forma:SolidPeso molecolare:403.39
