Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 208 prodotti di "Canale del sodio"
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Lamotrigine
CAS:Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.Formula:C9H7Cl2N5Purezza:99.76% - 99.95%Colore e forma:White To Pale Cream-Colored Powder Crystals From Isopropanol SolidPeso molecolare:256.09Methocarbamol
CAS:Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.Formula:C11H15NO5Purezza:99.96%Colore e forma:Crystals From Benzene SolidPeso molecolare:241.24Mexiletine hydrochloride
CAS:Mexiletine hydrochloride is a lidocaine-like antiarrhythmic (Class IB) and anesthetic, stabilizing heartbeats by inhibiting sodium in cardiac cells.Formula:C11H18ClNOPurezza:99.88%Colore e forma:White To Off-White SolidPeso molecolare:215.72Phenytoin sodium
CAS:Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .Formula:C15H11N2NaO2Purezza:99.88% - 99.92%Colore e forma:SolidPeso molecolare:274.25Mebeverine hydrochloride
CAS:Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gutFormula:C25H35NO5Purezza:99.81% - 99.81%Colore e forma:SolidPeso molecolare:429.55Nav1.8-IN-4
CAS:<p>Nav1.8-IN-4 is a potent Nav1.8 channel inhibitor with potential analgesic activity.Nav1.8-IN-4 can be used for pain and neurological related disorders.</p>Formula:C20H14F4N2O3Purezza:99.83%Colore e forma:SoildPeso molecolare:406.33DSP-2230
CAS:<p>DSP-2230 is a selective blocker of Nav1.7/Nav1.8.</p>Formula:C20H20F3N5O2Purezza:97.14%Colore e forma:SolidPeso molecolare:419.4Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Formula:C20H29N3O2Purezza:99.698% - 99.88%Colore e forma:Colorless Or Almost Colorless Powder SolidPeso molecolare:343.46Ranolazine dihydrochloride
CAS:<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>Formula:C24H35Cl2N3O4Purezza:99.30% - >99.99%Colore e forma:White Crystalline PowderPeso molecolare:500.46Oxybuprocaine hydrochloride
CAS:Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.Formula:C17H29ClN2O3Purezza:>99.99%Colore e forma:White Crystalline PowderPeso molecolare:344.88Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurezza:97% - 99.94%Colore e forma:Crystals White To Off-White PowderPeso molecolare:313.86Bupivacaine hydrochloride
CAS:Bupivacaine hydrochloride (Vivacaine) is a long-lasting, amide local anesthetic that blocks sodium channels, inhibiting nerve impulses and sensation.Formula:C18H28N2O·HClPurezza:99.89% - 99.9%Colore e forma:SolidPeso molecolare:324.89Ropivacaine
CAS:Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group.Formula:C17H26N2OPurezza:97.75% - >99.99%Colore e forma:SolidPeso molecolare:274.40Butamben
CAS:Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.Formula:C11H15NO2Purezza:99.43%Colore e forma:Crystals From Alc Physical Description Yellow Powder Insoluble In Water (Ntp 1992)Peso molecolare:193.24Oxcarbazepine
CAS:Oxcarbazepine (GP 47680), an anti-epileptic, reduces CNS disorganized electrical activity.Formula:C15H12N2O2Purezza:98.46%Colore e forma:Crystals From Ethanol SolidPeso molecolare:252.27Ropivacaine hydrochloride
CAS:Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activityFormula:C17H26N2O·HClPurezza:99.85% - 99.95%Colore e forma:SolidPeso molecolare:310.86Propafenone
CAS:<p>Propafenone: a drug for ventricular arrhythmias with mild beta-blocker activity, prolongs refractory period, and reduces heart automaticity.</p>Formula:C21H27NO3Purezza:99.02%Colore e forma:SolidPeso molecolare:341.44E 0747 FA
E 0747 FA is an antiarrhythmic compound that inhibits the voltage of action potential Vmax in Purkinje fibers of porcine heart.E 0747 FA inhibits Na channels in cardiac cells.Formula:C22H30ClN3O6Purezza:98.54%Colore e forma:SolidPeso molecolare:467.94NaV1.7 inhibitor-1
CAS:NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).Formula:C23H30FNO4SPurezza:99.89%Colore e forma:SolidPeso molecolare:435.55PF-04885614
CAS:<p>PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment.</p>Formula:C13H14F3N3OPurezza:98.02%Colore e forma:SolidPeso molecolare:285.27Diphenidol hydrochloride
CAS:Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.Formula:C21H28ClNOPurezza:99.15% - 99.33%Colore e forma:Crystals Soluble In Methanol WaterPeso molecolare:345.91Articaine hydrochloride
CAS:Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.Formula:C13H21ClN2O3SPurezza:99.76%Colore e forma:White Crystalline PowderPeso molecolare:320.84Amiloride hydrochloride
CAS:Amiloride hydrochloride (Amiloride HCl) 是上皮钠通道和尿激酶型纤溶酶原激活物受体的抑制剂，也是 polycystin-2通道阻断剂。Formula:C6H9Cl2N7OPurezza:99.72% - 99.95%Colore e forma:Physical Description Crystalline Solid Or Very Light Yellow Powder (Ntp 1992)Peso molecolare:266.09Tocainide
CAS:<p>Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus.</p>Formula:C11H16N2OPurezza:99.84%Colore e forma:SolidPeso molecolare:192.26Phenytoin
CAS:Phenytoin: a non-sedative hydantoin, antiepileptic with anticonvulsant effects, stabilizes neurons, prevents seizure spread, and relaxes muscles.Formula:C15H12N2O2Purezza:99.95%Colore e forma:Needles (Alcohol) Tasteless (Ntp 1992)Peso molecolare:252.27BIIB 722 Mesylate
CAS:<p>BIIB 722 Mesylate is a sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia.</p>Formula:C19H23F3N6O5SPurezza:99.57%Colore e forma:SoildPeso molecolare:504.483Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurezza:99.95% - >99.99%Colore e forma:Needles From Benzene Or Alcohol SolidPeso molecolare:234.34Topiramate
CAS:<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>Formula:C12H21NO8SPurezza:99.79% - 99.92%Colore e forma:White To Off-White Crystalline PowderPeso molecolare:339.36Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82Eleclazine hydrochloride
CAS:Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).Formula:C21H17ClF3N3O3Purezza:99.86%Colore e forma:SolidPeso molecolare:451.83Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Formula:C22H26N2O2Purezza:99.85% - 99.98%Colore e forma:White Crystalline SolidPeso molecolare:350.45Brompheniramine maleate
CAS:Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.Formula:C16H19BrN2·C4H4O4Purezza:99.80%Colore e forma:Crystal PowderPeso molecolare:435.31QX-314 chloride
CAS:<p>QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.</p>Formula:C16H27ClN2OPurezza:99.73%Colore e forma:SolidPeso molecolare:298.85Primidone
CAS:Primidone (NCI-C56360) is a potent anticonvulsant agent.Formula:C12H14N2O2Purezza:99.91%Colore e forma:Crystals (Ntp 1992)Peso molecolare:218.25Flunarizine dihydrochloride
CAS:<p>Flunarizine dihydrochloride: a calcium blocker also targeting calmodulin and histamine H1, used for migraine, vertigo, vascular disease, and epilepsy aid.</p>Formula:C26H28Cl2F2N2Purezza:99.53% - 99.89%Colore e forma:White Crystalline Powder Odorless And TastelessPeso molecolare:477.42Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formula:C14H23ClN2OPurezza:99.81% - 99.92%Colore e forma:White Crystal PowderPeso molecolare:270.798Meticrane
CAS:Meticrane (Arresten) is a sulphonamide-derivative with thiazide-like diuretic activity.Formula:C10H13NO4S2Purezza:99.16%Colore e forma:SolidPeso molecolare:275.34Disopyramide
CAS:Disopyramide, or Triombrin, a class I anti-arrhythmic with membrane-stabilizing effects, has heart depressant, anticholinergic, and anesthetic properties.Formula:C21H29N3OPurezza:99.62%Colore e forma:SolidPeso molecolare:339.47Tocainide hydrochloride
CAS:<p>Tocainide hydrochloride (2-amino-n-(2,6-dimethylphenyl)propanamide hydrochloride) is a sodium channel blocker.</p>Formula:C11H17ClN2OPurezza:97%Colore e forma:SolidPeso molecolare:228.72Phenazopyridine hydrochloride
CAS:Phenazopyridine HCl, an oral urinary analgesic, may cause nausea, anemia, and liver/kidney toxicity. Possibly carcinogenic.Formula:C11H12ClN5Purezza:99.27%Colore e forma:Brownish-Yellow Crystals Aqueous Solutions Are Yellow To Brick-Red And Slightly Acidic; They May Be Stabilized By The AdditionPeso molecolare:249.7Benzocaine
CAS:Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.Formula:C9H11NO2Purezza:99.16% - 99.88%Colore e forma:Rhombohedra From Ether DrypowderPeso molecolare:165.19GpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Colore e forma:Odour SolidIndenebart
Indenebart is a humanized IgG1λ2 monoclonal antibody targeting SNCA, with HumanIgG1lambda2, Isotype Control serving as the corresponding isotype control.Colore e forma:Odour LiquidCL-424032
CAS:CL-424032 is an inhibitor of sodium channels (sodium channel).Formula:C12H7F3N4O2Colore e forma:SolidPeso molecolare:296.21LTGO-33
CAS:<p>LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.</p>Formula:C21H17F4N3O3SPurezza:97.6%Colore e forma:SoildPeso molecolare:467.44ASG-5ME
ASG-5ME is a drug-antibody coupling targeting SLC44A4 that shows anti-tumor activity in xenograft models and may be used to study pancreatic and gastric cancer.Purezza:98.1% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.1% (SDS-PAGE); 98.5% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5 kDaSodium Channel Targeted Library
<p>A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;</p>Colore e forma:Odour SolidTrapencaine
CAS:<p>Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.</p>Formula:C22H34N2O3Purezza:98.96%Colore e forma:SolidPeso molecolare:374.52Zoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Formula:C17H16N6OPurezza:99.74%Colore e forma:SolidPeso molecolare:320.35Amlenetug
Amlenetug is a humanized IgG1κ antibody targeting SNCA, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidETD001
CAS:ETD001 is a long-acting ENaC inhibitor with an IC50 value of 57.5 nM in HBE cells. It is applicable for research in cystic fibrosis.Formula:C41H57F6N9O16Colore e forma:SolidPeso molecolare:1045.93Ion Channel Targeted Library
<p>A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;</p>Colore e forma:Odour SolidSolpecainol
CAS:solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Formula:C18H23NO3Purezza:99.71%Colore e forma:SoildPeso molecolare:301.38Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Formula:C31H42N2O6Peso molecolare:538.67Anthopleurin-A
CAS:Anthopleurin-A, a sodium channel toxin, is selective for cardiac channels and has a cardiotonic effect. It can be isolated from the sea anemone [1] [2].Formula:C220H326N64O67S6Peso molecolare:5131.72PF-06456384 trihydrochloride
CAS:PF-06456384 trihydrochloride is a selective NaV1.7 inhibitor acting through protein-ligand binding. intravenous infusion and pain research.Formula:C35H35Cl3F3N7O3S2Purezza:99.16%Colore e forma:SolidPeso molecolare:829.18Benzonatate (PEGn)
CAS:Benzonatate (PEGn) is a unique non-narcotic cough suppressant featuring sodium channel blocking properties and anesthetic effects on respiratory tract stretch receptors.Formula:(C2H4O)nC12H17NO2Colore e forma:SolidProTx II
CAS:<p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>Formula:C168H250N46O41S8Purezza:98%Colore e forma:SolidPeso molecolare:3826.59Mambalgin 1
CAS:ASIC1a inhibitor; IC50: 192 nM (human), 72 nM (dimer); inactive channel binding; selective; pain response delay.Formula:C272H429N85O84S10Purezza:98%Colore e forma:SolidPeso molecolare:6554.51APETx2
CAS:<p>ASIC3 inhibitor; IC50: 63 nM (rat), 175 nM (human). Blocks NaV1.8, NaV1.2; analgesic for acid/inflammatory pain.</p>Formula:C196H280N54O61S6Purezza:98%Colore e forma:SolidPeso molecolare:4561.06Zandatrigine
CAS:Zandatrigine (NBI-921352) is a blocker of sodium channel protein type 8 subunit alpha and can be used in studies about nervous system pathologies of epilepsyFormula:C22H25FN4O2S2Purezza:99.98%Colore e forma:SolidPeso molecolare:460.59Mepivacaine hydrochloride
CAS:Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties.Formula:C15H22N2O·HClPurezza:98.76% - 99.94%Colore e forma:White Or Off White Crystalline PowderPeso molecolare:282.811-(1-Methyl-1h-pyrazol-4-yl)-ethanone
CAS:1-(1-Methyl-1h-pyrazol-4-yl)-ethanone is a high purity biochemical reagent that can be used in research related to life sciences.Formula:C6H8N2OPurezza:99.92%Colore e forma:SolidPeso molecolare:124.14Myomodulin
CAS:Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A theFormula:C36H67N11O8S2Purezza:98%Colore e forma:SolidPeso molecolare:846.12SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Formula:C19H13ClN2O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:368.84Nav1.3 channel inhibitor 1
<p>Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM.</p>Formula:C19H15F2N3O3S2Purezza:98%Colore e forma:SolidPeso molecolare:435.47Zoniporide hydrochloride
CAS:Zoniporide hydrochloride: selective NHE-1 inhibitor, IC50 14 nM, >150x selectivity over other NHEs, inhibits platelet swelling (IC50 59 nM).Formula:C17H17ClN6OPurezza:99.68%Colore e forma:SolidPeso molecolare:356.81Nav1.7-IN-18
Nav1.7-IN-18 (Compound 31) is a Nav1.7 inhibitor with a Ki value of 4.9 nM and an IC50 of 13 nM, demonstrating analgesic effects in transgenic mice with inherited erythromelalgia (IEM).Formula:C30H33Cl2F2NO4Colore e forma:SolidPeso molecolare:580.49Veratridine
CAS:<p>Veratridine is a benzoate-cevane found in Veratrum and Schoenocaulon. It activates sodium channels to stay open longer than normal.</p>Formula:C36H51NO11Purezza:98.07% - 99.27%Colore e forma:Yellowish-White Amorphous Powder PowderPeso molecolare:673.79Ancistrotecine B
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].Formula:C26H31NO4Purezza:98%Colore e forma:SolidPeso molecolare:421.53Lifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Formula:C30H34N4O2Purezza:99.55%Colore e forma:SolidPeso molecolare:482.62GX 201
CAS:<p>GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.</p>Formula:C25H27ClF4N2O4SPurezza:99.81%Colore e forma:SolidPeso molecolare:563Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Formula:C176H269N51O48S6Purezza:98%Colore e forma:SolidPeso molecolare:4059.74OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Formula:C308H466N90O95S8Purezza:98%Colore e forma:SolidPeso molecolare:7206.1Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Formula:C174H278N52O51S6Purezza:98%Colore e forma:SolidPeso molecolare:4106.795-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurezza:97.87%Colore e forma:SolidPeso molecolare:200.36ProTx II TFA
ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 of 0.3 nM and demonstrating at least 100-fold selectivity overFormula:C168H250N46O41S8·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3826.59 (free base)NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Formula:C23H20ClN3O3Colore e forma:SolidPeso molecolare:421.11932Halazone
CAS:Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.Formula:C7H5Cl2NO4SPurezza:98.64%Colore e forma:Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Peso molecolare:270.09Analgesic agent-2
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the humanFormula:C21H21ClF2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:434.87Poneratoxin acetate
<p>Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain.</p>Formula:C129H215N33O31S·xC2H4O2Colore e forma:SolidPeso molecolare:2756.35 (free base)Bulleyaconitine A
CAS:Bulleyaconitine A, an analgesic and antiinflammatory drug isolated from Aconitum plants, has several potential targets, such as voltage-gated Na+ channels.Formula:C35H49NO9Purezza:99.56% - 99.76%Colore e forma:SolidPeso molecolare:627.7610,11-Dihydro-10-hydroxycarbamazepine-d4
CAS:10,11-Dihydro-10-hydroxycarbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxycarbamazepine.Formula:C15H10D4N2O2Peso molecolare:258.31Ethacizine hydrochloride
CAS:<p>Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity and can be used to study arrhythmias and myocardial infarction.</p>Formula:C22H28ClN3O3SPurezza:98.08% - 98.08%Colore e forma:SolidPeso molecolare:449.99AM-2099
CAS:AM-2099 is a selective voltage-gated sodium channel Nav1.7 inhibitor used in pain research.Formula:C19H13F3N4O3S2Colore e forma:SolidPeso molecolare:466.46Dibucaine hydrochloride
CAS:<p>Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.</p>Formula:C20H30ClN3O2Purezza:99.66%Colore e forma:White PowderPeso molecolare:379.92Mexiletine-d6 hydrochloride
CAS:Mexiletine D6 hydrochloride is a non-selective voltage-gated sodium channel blocker,is a Class IB antianhythmic.Formula:C11H18ClNOPurezza:98%Colore e forma:SolidPeso molecolare:221.76PF-04856264
CAS:PF-04856264 is a Nav1.7 blocker.,modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain analgesic.Formula:C20H15N5O3S2Purezza:97.43%Colore e forma:SolidPeso molecolare:437.5Mepivacaine
CAS:<p>Mepivacaine (Carbocaine) is an amide local anesthetic, blocking sodium channels for nerve blocks and epidurals.</p>Formula:C15H22N2OPurezza:99.35%Colore e forma:SolidPeso molecolare:246.35Triamterene D5
CAS:Triamterene D5 is a deuterium-labeled Triamterene and can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, used as a mild diuretic.Formula:C12H11N7Purezza:98%Colore e forma:SolidPeso molecolare:258.29BI-9627
CAS:BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) (EC50: 31 nM).Formula:C16H19F3N4O2Purezza:99.77%Colore e forma:SolidPeso molecolare:356.34Ranolazine
CAS:Ranolazine (RS 43285-003) inhibits calcium uptake, treats chronic angina by targeting sodium/calcium channels to modulate intracellular sodium.Formula:C24H33N3O4Purezza:98.13%Colore e forma:White SolidPeso molecolare:427.54Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Formula:C17H29ClN2O2Purezza:99.94% - 99.95%Colore e forma:White SolidPeso molecolare:328.88GNE-131
CAS:<p>GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM).</p>Formula:C23H30N4O3SPurezza:98.54% - 99.59%Colore e forma:SolidPeso molecolare:442.57Flecainide acetate
CAS:Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).Formula:C19H24F6N2O5Purezza:99.42%Colore e forma:SolidPeso molecolare:474.39Fosphenytoin disodium
CAS:Fosphenytoin disodium (ACC-9653) is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blockerFormula:C16H13N2Na2O6PPurezza:99.97%Colore e forma:White Crystalline PowderPeso molecolare:406.24DS-1971a
CAS:<p>DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.</p>Formula:C20H21ClFN5O3SPurezza:99.66%Colore e forma:SolidPeso molecolare:465.93Cariporide
CAS:Cariporide (HOE-642), an NHE1 inhibitor, reduces human platelet degranulation, platelet-leukocyte aggregates, and GPIIb/IIIa activation.Formula:C12H17N3O3SPurezza:95.4% - 99.88%Colore e forma:SolidPeso molecolare:283.35Rimeporide hydrochloride
CAS:Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Formula:C11H16ClN3O5S2Purezza:99.82%Colore e forma:SolidPeso molecolare:369.84Licarbazepine
CAS:<p>Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial</p>Formula:C15H14N2O2Purezza:99.11%Colore e forma:SolidPeso molecolare:254.28Nav1.8-IN-1
CAS:<p>Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8</p>Formula:C20H15ClF3N3O2Purezza:97.59%Colore e forma:SolidPeso molecolare:421.8QX-222 chloride
CAS:<p>QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.</p>Formula:C13H21ClN2OPurezza:97.37%Colore e forma:SolidPeso molecolare:256.77Carbamazepine
CAS:Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.Formula:C15H12N2OPurezza:99.78% - 99.79%Colore e forma:SolidPeso molecolare:236.27λ-Cyhalothrin
CAS:<p>λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.</p>Formula:C23H19ClF3NO3Purezza:99.76%Colore e forma:SolidPeso molecolare:449.85Rimeporide
CAS:<p>Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.</p>Formula:C11H15N3O5S2Purezza:97.66%Colore e forma:SolidPeso molecolare:333.38Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Formula:C17H21ClF6N2O3Purezza:97.79%Colore e forma:SolidPeso molecolare:450.81Raxatrigine
CAS:Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.Formula:C18H19FN2O2Purezza:98% - 99.43%Colore e forma:SolidPeso molecolare:314.35N-Me-aminopyrimidinone9
CAS:<p>N-Me-aminopyrimidinone9 is a sodium channel antagonist</p>Formula:C16H21N3OSPurezza:99.21%Colore e forma:SolidPeso molecolare:303.42Levobupivacaine
CAS:<p>Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.</p>Formula:C18H28N2OPurezza:99.72%Colore e forma:SolidPeso molecolare:288.43Propafenone hydrochloride
CAS:<p>Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.</p>Formula:C21H27NO3·HClPurezza:99.67%Colore e forma:White SolidPeso molecolare:377.9Benzocaine xHCl(94-09-7(free base))
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).Formula:C9H11NO2·xHClPurezza:99.37%Colore e forma:SolidPeso molecolare:N/AVX-150
CAS:<p>VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).</p>Formula:C21H17F4N2O7PPurezza:97.58%Colore e forma:SolidPeso molecolare:516.34PF-01247324
CAS:PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).Formula:C13H10Cl3N3OPurezza:99.22%Colore e forma:SolidPeso molecolare:330.6PF 05089771
CAS:PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.Formula:C18H12Cl2FN5O3S2Purezza:99.03% - 99.42%Colore e forma:SolidPeso molecolare:500.35PF-05186462
CAS:<p>PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.</p>Formula:C19H10ClF4N5O3S2Purezza:99.10% - 99.37%Colore e forma:SolidPeso molecolare:531.89Ralfinamide mesylate
CAS:<p>Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.</p>Formula:C18H23FN2O5SPurezza:99.83%Colore e forma:SolidPeso molecolare:398.45Ajmaline
CAS:Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.Formula:C20H26N2O2Purezza:99.67% - 99.87%Colore e forma:SolidPeso molecolare:326.43ICA-121431
CAS:<p>ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.</p>Formula:C23H19N3O3S2Purezza:98.06%Colore e forma:SolidPeso molecolare:449.55(+)-Kavain
CAS:(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.Formula:C14H14O3Purezza:97% - ≥95%Colore e forma:White Fine PowderPeso molecolare:230.26Benzamil
CAS:Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.Formula:C13H14ClN7OPurezza:99.79%Colore e forma:SolidPeso molecolare:319.7520(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purezza:98.11% - 99.93%Colore e forma:SolidPeso molecolare:785.01Dronedarone
CAS:<p>Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.</p>Formula:C31H44N2O5SPurezza:98.85% - 99.58%Colore e forma:SolidPeso molecolare:556.76Evenamide
CAS:<p>Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.</p>Formula:C16H26N2O2Purezza:96.74% - 99.15%Colore e forma:SolidPeso molecolare:278.39Metaflumizone
CAS:Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.Formula:C24H16F6N4O2Purezza:98.73%Colore e forma:SolidPeso molecolare:506.40Cyfluthrin
CAS:Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pestsFormula:C22H18Cl2FNO3Purezza:99.76%Colore e forma:SolidPeso molecolare:434.29A-803467
CAS:A-803467 is a selective NaV1.8 channel blocker.Formula:C19H16ClNO4Purezza:96.94% - 98%Colore e forma:SolidPeso molecolare:357.79Metergoline
CAS:Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.Formula:C25H29N3O2Purezza:99.83% - 99.97%Colore e forma:SolidPeso molecolare:403.52Tenapanor
CAS:Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.Formula:C50H66Cl4N8O10S2Purezza:99.49% - 99.85%Colore e forma:SolidPeso molecolare:1145.05Dimethyl lithospermate B
CAS:Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.Formula:C38H34O16Purezza:97.18% - 99.62%Colore e forma:SolidPeso molecolare:746.67Eslicarbazepine Acetate
CAS:Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Formula:C17H16N2O3Purezza:99.58% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:296.32Nicainoprol
CAS:Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.Formula:C21H27N3O3Purezza:99.54%Colore e forma:SolidPeso molecolare:369.46Sodium ionophore III
CAS:Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.Formula:C34H52N2O4Purezza:99.51% - 99.78%Colore e forma:SolidPeso molecolare:552.79BI 01383298
CAS:BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).Formula:C19H19Cl2FN2O3SPurezza:99.71%Colore e forma:SolidPeso molecolare:445.34GS967
CAS:<p>GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).</p>Formula:C14H7F6N3OPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:347.22Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFormula:C17H25ClN2OPurezza:99.01% - 99.80%Colore e forma:SolidPeso molecolare:308.85AZ194
CAS:CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.Formula:C34H31F2N3O3Purezza:99.61%Colore e forma:SolidPeso molecolare:567.62RY785
CAS:<p>RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.</p>Formula:C21H20N4O2SPurezza:99.78%Colore e forma:SolidPeso molecolare:392.476-Benzoylheteratisine
CAS:6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.Formula:C29H37NO6Purezza:99.87%Colore e forma:SolidPeso molecolare:495.61Benzonatate
CAS:Benzonatate is an antagonist of sodium channel protein.Formula:C30H53NO11Purezza:99.92%Colore e forma:Colorless To Faintly Yellow Oil LiquidPeso molecolare:603.74PF-06869206
CAS:PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).Formula:C15H14ClF3N4O2Purezza:99.79% - 99.88%Colore e forma:SolidPeso molecolare:374.75Levobupivacaine hydrochloride
CAS:<p>Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.</p>Formula:C18H28N2O·HClPurezza:99.74%Colore e forma:White Crystalline PowderPeso molecolare:324.893-Deoxyaconitine
CAS:3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thusFormula:C34H47NO10Purezza:98.31%Colore e forma:SolidPeso molecolare:629.74Ralfinamide
CAS:Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.Formula:C17H19FN2O2Purezza:99.41%Colore e forma:SolidPeso molecolare:302.34Benzocaine N-Glucoside (a/b mixture)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Formula:C15H21NO7Colore e forma:NeatPeso molecolare:327.33Propoxycaine hydrochloride
CAS:Propoxycaine hydrochloride is an ester local anesthetic that inhibits voltage-gated sodium channels, modulates nerve impulses, and induces loss of sensation.Formula:C16H27ClN2O3Purezza:97.25%Colore e forma:SolidPeso molecolare:330.85N-Formylguanidine
CAS:Prodotto controllatoFormula:C2H5N3OColore e forma:Off-WhitePeso molecolare:87.081Riluzole
CAS:<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formula:C8H5F3N2OSPurezza:99.71% - 99.88%Colore e forma:PowderPeso molecolare:234.2Propafenone-d5 HCl
CAS:Propafenone-d5 HCl is a deuterated compound of Propafenone HCl. Propafenone HCl has a CAS number of 34183-22-7. Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.Formula:C21H23D5ClNO3Peso molecolare:382.9410,11-Dihydro-10-hydroxy Carbamazepine-d4
CAS:10,11-Dihydro-10-hydroxy Carbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxy Carbamazepine. 10,11-Dihydro-10-hydroxy Carbamazepine has a CAS number of 29331-92-8. Licarbazepine is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.Formula:C15H10D4N2O2Peso molecolare:258.313-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS:Prodotto controllato<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Formula:C10H12ClNO3SColore e forma:NeatPeso molecolare:261.73N-(Chloroacetyl)-2,5-dimethylaniline
CAS:Prodotto controllato<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Formula:C10H12ClNOColore e forma:NeatPeso molecolare:197.66Deacetamide Acetonitrile-pentisomide
CAS:Prodotto controllato<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Formula:C19H31N3Colore e forma:NeatPeso molecolare:301.47Methocarbamol D5
CAS:Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.Formula:C11H15NO5Purezza:98%Colore e forma:SolidPeso molecolare:246.27Propafenone D7 hydrochloride
CAS:Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.Formula:C21H28ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:384.95Nav1.8-IN-14
CAS:Nav1.8-IN-14 (compound 20) is an effective selective inhibitor of Nav1.8. It is utilized in the research of pain-associated diseases.Formula:C18H17F5N4O3SPeso molecolare:464.411,2,4-Oxadiazol-3-amine
CAS:Prodotto controllato<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Formula:C2H3N3OColore e forma:NeatPeso molecolare:85.063-Deoxyyunaconitine
CAS:Prodotto controllato<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Formula:C35H49NO10Colore e forma:NeatPeso molecolare:643.766-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Prodotto controllato<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formula:C17H28N2O2Colore e forma:NeatPeso molecolare:292.416Clopamide
CAS:Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Formula:C14H20ClN3O3SPurezza:99.71%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:345.84Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formula:C16H17BrClN3O3Purezza:99.53%Colore e forma:Off-White SolidPeso molecolare:414.68GX-674
CAS:GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study ofFormula:C21H13ClF2N6O3S2Purezza:98.60%Colore e forma:SolidPeso molecolare:534.95Halofuginone hydrobromide
CAS:<p>Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.</p>Formula:C16H17BrClN3O3·HBrPurezza:97.01% - 99.73%Colore e forma:SolidPeso molecolare:495.59GX-585
CAS:<p>GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.</p>Formula:C24H25Cl2FN4O3SPurezza:99.02% - 99.03%Colore e forma:SolidPeso molecolare:539.45(5R)-BW-4030W92
CAS:(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.Formula:C11H9Cl2FN4Purezza:98.27%Colore e forma:SolidPeso molecolare:287.12Phenamil
CAS:Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.Formula:C12H12ClN7OPurezza:99.07%Colore e forma:SolidPeso molecolare:305.72GDC-0276
CAS:GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.Formula:C24H31FN2O4SPurezza:99.77%Colore e forma:SolidPeso molecolare:462.58NHE3-IN-2
CAS:NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.Formula:C15H12ClN5Colore e forma:SolidPeso molecolare:297.74PF 05089771 tosylate
CAS:PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.Formula:C18H12Cl2FN5O3S2·C7H8O3SPurezza:98.55%Colore e forma:SolidPeso molecolare:672.56DPI 201-106
CAS:<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Formula:C29H30N4O2Purezza:99.94%Colore e forma:SolidPeso molecolare:466.57GNE-0439
CAS:GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.Formula:C21H31NO3Purezza:99.60%Colore e forma:SolidPeso molecolare:345.48Sodium Channel inhibitor 2
CAS:Sodium Channel inhibitor 2 is a blocker of sodium channel.Formula:C26H25Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:466.4Nav1.7 inhibitor
CAS:Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.Formula:C15H11Cl3FNO4SPurezza:97.52%Colore e forma:SolidPeso molecolare:426.68E 0747
CAS:<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Formula:C21H28ClN3O4Purezza:95.17%Colore e forma:SolidPeso molecolare:421.92Elpetrigine
CAS:Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.Formula:C10H7Cl3N4Purezza:99.04% - 99.43%Colore e forma:SolidPeso molecolare:289.55TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Formula:C25H27F3N6O3Purezza:99.71%Colore e forma:SolidPeso molecolare:516.52Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFormula:C17H21NO2·HClPurezza:99.21%Colore e forma:White SolidPeso molecolare:307.82Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Formula:C15H25ClFNSiPurezza:99.97%Colore e forma:SolidPeso molecolare:301.9NaV1.2/1.6 channel blocker-1
CAS:NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.Formula:C14H14N2OSPurezza:99.54%Colore e forma:SolidPeso molecolare:258.34NHE3-IN-1
CAS:<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Formula:C12H10ClN3SPurezza:99.93%Colore e forma:SolidPeso molecolare:263.75Ralitoline
CAS:<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Formula:C13H13ClN2O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:296.77KR-32568
CAS:<p>KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).</p>Formula:C13H12FN3O2Purezza:99.91%Colore e forma:SolidPeso molecolare:261.25SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Formula:C19H19Cl3N2O3SPurezza:99.67%Colore e forma:SolidPeso molecolare:461.79(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Formula:C25H16ClF2N3O5SPurezza:99.6%Colore e forma:SolidPeso molecolare:543.93GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Formula:C25H29Cl2FN2O4SPurezza:99.877%Colore e forma:SolidPeso molecolare:543.486-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Formula:C6H8IN7OPurezza:98%Colore e forma:SolidPeso molecolare:321.08Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Formula:C14H12FN3O2Purezza:99.82%Colore e forma:SolidPeso molecolare:273.26Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Formula:C19H18ClN3O4S2Purezza:98%Colore e forma:SolidPeso molecolare:451.95Aneratrigine
CAS:Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].Formula:C19H20ClF2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:487.97PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Formula:C17H16ClN5O2Purezza:99.85%Colore e forma:SolidPeso molecolare:357.79Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Formula:C22H14F3NO5Purezza:99.91%Colore e forma:SolidPeso molecolare:429.35VGSCs-IN-1
CAS:<p>VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.</p>Formula:C12H12F3N3OSPurezza:99.88%Colore e forma:SolidPeso molecolare:303.3Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Formula:C19H21Cl2F2N5O2S2Purezza:98.37% - 99.16%Colore e forma:SolidPeso molecolare:524.43ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Colore e forma:SolidPeso molecolare:434.307N-Depropylpropafenone
CAS:N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.Formula:C18H21NO3Colore e forma:SolidPeso molecolare:299.36Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Formula:C22H21FN4O4Peso molecolare:424.42Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Formula:C23H15F4N3O2Peso molecolare:441.38Quinacainol dihydrochloride
CAS:<p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>Formula:C21H32Cl2N2OColore e forma:SolidPeso molecolare:399.398Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formula:C25H35BrN2Colore e forma:SolidPeso molecolare:443.463PF-05661014
CAS:<p>PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.</p>Formula:C17H16N4O3S2Colore e forma:SolidPeso molecolare:388.46Lubeluzole dihydrochloride
CAS:<p>Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.</p>Formula:C22H27Cl2F2N3O2SColore e forma:SolidPeso molecolare:506.44
