IDO
L'indoleamina 2,3-diossigenasi (IDO) è un enzima coinvolto nel catabolismo del triptofano, che porta alla produzione di chinurenina e altri metaboliti. L'IDO svolge un ruolo nella tolleranza immunitaria ed è spesso sovraregolato nel cancro e nelle condizioni infiammatorie croniche. Gli inibitori dell'IDO vengono esplorati come potenziali agenti immunoterapici nel cancro e nelle malattie autoimmuni. Presso CymitQuimica, forniamo inibitori dell'IDO per supportare la tua ricerca in immunologia, oncologia e regolazione metabolica.
Trovati 88 prodotti per "IDO".
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IDO antagonist-1
CAS:IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].Formula:C39H53N7O5Colore e forma:SolidPeso molecolare:699.88IDO1 ligand-1
CAS:IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.Formula:C29H34FN3O2Colore e forma:SolidPeso molecolare:475.598VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Formula:C29H27N5O3Colore e forma:SolidPeso molecolare:493.56Pronqodine A
CAS:Pronqodine A is a quinone isolated from Streptomyces, known for its enzyme inhibitory and anti-inflammatory properties. It targets NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = 131.5 nM). In SW 982 human synovial sarcoma cells, it suppresses bradykinin-induced production of prostaglandin E2 (PGE2), 6-keto PGF1α, and PGD2, with IC50 values of 9, 19, and 7 nM, respectively, and it also promotes the generation of reactive oxygen species (ROS) in these cells.Formula:C8H6N2O2SPeso molecolare:194.21IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Formula:C20H16BrN5O2SColore e forma:SolidPeso molecolare:470.34IDO1-IN-14
IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.Formula:C18H12Cl2FN3O2Colore e forma:SolidPeso molecolare:392.21IDO2-IN-1
CAS:IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.Formula:C21H21BrN10O3Colore e forma:SolidPeso molecolare:541.36IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Formula:C14H8Cl3NO2SColore e forma:SolidPeso molecolare:360.64
