Prolil-idrossilasi HIF/HIF
Il fattore inducibile dall'ipossia (HIF) è un fattore di trascrizione che svolge un ruolo cruciale nelle risposte cellulari ai bassi livelli di ossigeno (ipossia). L'attività di HIF è strettamente regolata dalle prolyl-idrossilasi HIF, che bersagliano HIF per la degradazione in condizioni normossiche. Gli inibitori della prolyl-idrossilasi HIF possono stabilizzare HIF, promuovendo l'espressione di geni coinvolti nell'angiogenesi, eritropoiesi e metabolismo. Questi inibitori sono di grande interesse per il trattamento di condizioni come anemia, malattie ischemiche e cancro. Presso CymitQuimica, offriamo inibitori di HIF/prolyl-idrossilasi HIF per supportare la tua ricerca in biologia dell'ipossia, terapia anticancro e regolazione metabolica.
Trovati 142 prodotti di "Prolil-idrossilasi HIF/HIF"
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HIF-IN-1
CAS:<p>HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.</p>Formula:C17H12N2OPurezza:99.48%Colore e forma:SolidPeso molecolare:260.29HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurezza:99.90% - >99.99%Colore e forma:SolidPeso molecolare:361.461,4-DPCA ethyl ester
CAS:<p>1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.</p>Formula:C15H12N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:268.27UNC6934
CAS:<p>UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.</p>Formula:C24H21N5O4Purezza:98.67%Colore e forma:SolidPeso molecolare:443.45TP0463518
CAS:TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).Formula:C20H18ClN3O6Purezza:99.52%Colore e forma:SolidPeso molecolare:431.83HNHA
CAS:<p>HNHA is an inhibitor of HDAC.</p>Formula:C17H21NO2SPurezza:98.04%Colore e forma:SolidPeso molecolare:303.42Ethyl 3,4-dihydroxybenzoate
CAS:<p>Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.</p>Formula:C9H10O4Purezza:99.88%Colore e forma:White Crystal Or PowderPeso molecolare:182.17Fraxinellone
CAS:<p>1.</p>Formula:C14H16O3Purezza:99.35% - 99.92%Colore e forma:SolidPeso molecolare:232.27AKBA
CAS:<p>AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.</p>Formula:C32H48O5Purezza:97.85% - 99.77%Colore e forma:SolidPeso molecolare:512.72Izilendustat hydrochloride
CAS:<p>Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.</p>Formula:C22H29Cl2N3O4Colore e forma:SolidPeso molecolare:470.39FG-2216
CAS:<p>FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.</p>Formula:C12H9ClN2O4Purezza:97.1% - >99.99%Colore e forma:SolidPeso molecolare:280.66N-Oxalylglycine
CAS:<p>N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.</p>Formula:C4H5NO5Purezza:99.23%Colore e forma:Colourless SolidPeso molecolare:147.09IDF-11774
CAS:<p>IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).</p>Formula:C23H32N2O2Purezza:98.05%Colore e forma:SolidPeso molecolare:368.51IOX2
CAS:<p>IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.</p>Formula:C19H16N2O5Purezza:98% - 99.59%Colore e forma:SolidPeso molecolare:352.34ZINC13466751
CAS:<p>ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).</p>Formula:C20H21N5O2Purezza:99.8%Colore e forma:SolidPeso molecolare:363.41Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Formula:C6H13NO5·H2SO4Purezza:99.64%Colore e forma:White CrystalPeso molecolare:277.25M1001
CAS:<p>M1001 is a HIF-2α agonist.</p>Formula:C17H17N3O2SPurezza:98.83%Colore e forma:SolidPeso molecolare:327.4Deoxyshikonin
CAS:<p>1.</p>Formula:C16H16O4Purezza:99.36% - ≥95%Colore e forma:SolidPeso molecolare:272.3VH-298
CAS:<p>VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.</p>Formula:C27H33N5O4SPurezza:99.17% - >99.99%Colore e forma:SolidPeso molecolare:523.65PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formula:C13H8N4Purezza:99.74%Colore e forma:SolidPeso molecolare:220.23GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Formula:C18H15N3O2Purezza:99.52%Colore e forma:SolidPeso molecolare:305.33B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purezza:99.66%Colore e forma:SolidPeso molecolare:396.83BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:525.53Chlorogenic Acid
CAS:<p>Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.</p>Formula:C16H18O9Purezza:98.84% - 99.67%Colore e forma:SolidPeso molecolare:354.31JNJ-42041935
CAS:<p>JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.</p>Formula:C12H6ClF3N4O3Purezza:99.58% - ≥95%Colore e forma:SolidPeso molecolare:346.65dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Formula:C5H8N2O5Purezza:99.93% - ≥95%Colore e forma:SolidPeso molecolare:176.13Dapagliflozin
CAS:<p>Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.</p>Formula:C21H25ClO6Purezza:99.5% - 99.93%Colore e forma:SolidPeso molecolare:408.87DMOG
CAS:<p>DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.</p>Formula:C6H9NO5Purezza:80.23% - 99.98%Colore e forma:SolidPeso molecolare:175.14MK-8617
CAS:<p>MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).</p>Formula:C24H21N5O4Purezza:99.38% - >99.99%Colore e forma:SolidPeso molecolare:443.45KC7F2
CAS:<p>KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.</p>Formula:C16H16Cl4N2O4S4Purezza:98% - 99.11%Colore e forma:SolidPeso molecolare:570.382,4-DPD
CAS:<p>2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)</p>Formula:C11H13NO4Purezza:99.74%Colore e forma:Yellow Solid CrystallinePeso molecolare:223.23HIF-2α-IN-4
CAS:<p>HIF-2a translation inhibitor is a compound used as a molecular building block.</p>Formula:C9H9N3O4S2Purezza:≥98%Colore e forma:SolidPeso molecolare:287.32PT-2385
CAS:<p>PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).</p>Formula:C17H12F3NO4SPurezza:98.91% - 99.55%Colore e forma:SolidPeso molecolare:383.34Oroxylin A
CAS:<p>Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.</p>Formula:C16H12O5Purezza:98.72% - 99.55%Colore e forma:SolidPeso molecolare:284.26IOX4
CAS:<p>IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)</p>Formula:C15H16N6O3Purezza:99.97%Colore e forma:SolidPeso molecolare:328.33Panaxadiol
CAS:<p>Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.</p>Formula:C30H52O3Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:460.73LW6
CAS:<p>LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.</p>Formula:C26H29NO5Purezza:98.1% - 98.22%Colore e forma:SolidPeso molecolare:435.51Belzutifan
CAS:<p>"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."</p>Formula:C17H12F3NO4SPurezza:99.34% - 99.88%Colore e forma:SolidPeso molecolare:383.34Amifostine trihydrate
CAS:<p>Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.</p>Formula:C5H15N2O3PS·3H2OPurezza:99.71% - 99.80%Colore e forma:SolidPeso molecolare:268.27PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formula:C13H20Cl4N2O3Purezza:97% - 99.79%Colore e forma:SolidPeso molecolare:394.12Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Formula:C16H16N2O4Purezza:98%Colore e forma:SolidPeso molecolare:300.31E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Formula:C21H30O6Purezza:99.52%Colore e forma:SolidPeso molecolare:378.46OHM1
CAS:<p>OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53</p>Formula:C24H42N6O5Colore e forma:SolidPeso molecolare:494.63CL67
CAS:<p>CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.</p>Formula:C38H42N10O2Colore e forma:SolidPeso molecolare:670.81ZK-261991
CAS:<p>ZK-261991 is an orally active inhibitor of VEGFR tyrosine kinase(IC50 of 5 nM, VEGFR2).</p>Formula:C24H25N7O2Purezza:98%Colore e forma:SolidPeso molecolare:443.5Dimethyl-bisphenol A
CAS:<p>DMBPA inhibits HIF-1α, promotes its degradation by detaching Hsp90, and reduces Vegfa mRNA expression.</p>Formula:C17H20O2Colore e forma:SolidPeso molecolare:256.34FM19G11
CAS:<p>FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).</p>Formula:C23H17N3O8Purezza:99.70%Colore e forma:SolidPeso molecolare:463.4GSK360A
CAS:<p>GSK360A is a novel prolyl hydroxylase (PHD) domain-containing enzyme inhibitor.</p>Formula:C17H17FN2O5Purezza:98%Colore e forma:SolidPeso molecolare:348.33HIF-1α-IN-3
CAS:<p>HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].</p>Formula:C19H17N5O2Colore e forma:SolidPeso molecolare:347.37TM6008
CAS:<p>TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.</p>Formula:C21H17N5O3Purezza:98%Colore e forma:SolidPeso molecolare:387.39
