Anidrasi carbonica
L'anidrasi carbonica è un enzima che catalizza la conversione reversibile del diossido di carbonio e acqua in bicarbonato e protoni. Questo enzima svolge un ruolo cruciale nel mantenimento dell'equilibrio acido-base, nella respirazione e nel trasporto di anidride carbonica nel sangue. Gli inibitori dell'anidrasi carbonica sono utilizzati nel trattamento del glaucoma, dell'epilessia e del mal di montagna, nonché nella ricerca sull'omeostasi acido-base e lo scambio gassoso. Presso CymitQuimica, offriamo una gamma di inibitori dell'anidrasi carbonica e reagenti di alta qualità per supportare la tua ricerca in enzimologia, fisiologia respiratoria e sviluppo terapeutico.
Trovati 220 prodotti per "Anidrasi carbonica".
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IPM-N001
IPM-N001 is a ligand for carbonic anhydrase IX (CAIX) with a Kd value of less than 0.0337 nM for hCAIX. When radiolabeled with 68Ga, it serves as a CAIX-targeting radionuclide tracer. [68Ga]Ga-IPM-N001 demonstrates excellent tumor uptake and significantly enhances the tumor-to-background ratio in PET/CT imaging studies using OS-RC-2 tumor-bearing mice. IPM-N001 is applicable for research on clear cell renal cell carcinoma.CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Formula:C23H21N5O3SColore e forma:SolidPeso molecolare:447.51Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formula:C7H6ClN3O4S2Purezza:98.46% - 98.91%Colore e forma:White SolidPeso molecolare:295.72CAIX/CAXII-IN-2
CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor, exhibiting Ki values of 8.9 nM for CAIX and 5.3 nM for CAXII. It is applicable in cancer research.Formula:C16H14N4O2SPeso molecolare:326.083755,6-Dihydro-2H-pyran-2-one
CAS:5,6-Dihydro-2H-pyran-2-one is a carbonic anhydrase 1/9 inhibitor that inhibits KB cell viability.Formula:C5H6O2Colore e forma:SolidPeso molecolare:98.0999hCAIX-IN-17
hCA IX-IN-1 inhibits hCA I/II/IX/XII with Ki of 331.4/28.4/9.4/17.8 nM, has anticancer properties.Formula:C19H18N2O3SColore e forma:SolidPeso molecolare:354.42Carbonic anhydrase-IN-37
Carbonic anhydrase-IN-37 (compound 9a) is a potent and orally active inhibitor of carbonic anhydrase (CA), exhibiting Ki values of 9.7 nM for hCA VA and 1.0 nM for hCA VB. It demonstrates anti-hyperalgesic and anti-allodynic properties in a mouse model of paclitaxel-induced neuropathic pain, making it useful for neuropathic pain research.hCAII-IN-8
CAS:Compound CDy9 is a highly selective inhibitor of carbonic anhydrase (CA) with an IC50 value of 0.18 μM for hCA II.Formula:C15H16N2O5SPurezza:99.73%Colore e forma:White SolidPeso molecolare:336.36hCA-IN-1
hCA-IN-1 (Compound 5u) is an hCA inhibitor with Ki values of 159.2 nM for hCA I, 4.8 nM for hCA II, 15.5 nM for CAIX, and 2 nM for CAXII. It demonstrates broad-spectrum anticancer activity against melanoma, breast cancer, and colon cancer cells. ADME predictions indicate that hCA-IN-1 has good solubility and oral bioavailability. This compound is useful in tumor research.hCA/VEGFR-2-IN-2
Compound 8g (hCA/VEGFR-2-IN-2) is an indolinonylbenzenesulfonamide identified as a potential dual inhibitor targeting cancer-associated isozymes hCA IX/XII andFormula:C23H26N6O5SPurezza:98%Colore e forma:SolidPeso molecolare:498.55hCAIX-IN-19
hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/Colore e forma:Odour SolidCAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Colore e forma:Odour SolidhCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2.Formula:C24H28N6O6SPurezza:98%Colore e forma:SolidPeso molecolare:528.58Dorzolamide
CAS:Dorzolamide is an anti-glaucoma agent and is a carbonic anhydrase inhibitor.Formula:C10H16N2O4S3Purezza:98%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:324.44CAI-IN-6
CAI-IN-6 (Compound 3F) is an inhibitor of carbonic anhydrase (CAI), exhibiting a Ki of 902.1 nM for hCA I and 86.1 nM for hCA II. It is useful in research related to diuretics, glaucoma, epilepsy, and tumors.Carbonic anhydrase inhibitor 20
Carbonic anhydrase inhibitor20 (compound 11) is an inhibitor of piperazine-based sulfonamide carbonic anhydrase (Carbonic Anhydrase). It has Ki values of 47.6 nM, 36.5 nM, 8.3 nM, and 2.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively.Formula:C24H30N4O4SPeso molecolare:470.19878hCAIX-IN-21
hCAIX-IN-21 (compound 16c) is an effective inhibitor of hCAIX, exhibiting KI values of 5.2 nM, 3.5 nM, 12.6 nM, and 13600 nM against hCAIX, hCA II, hCA XII, and hCA I, respectively. Moreover, it inhibits the enzymatic activity of tissue protease B.2-Cyclohexylethylamine Hydrochloride
CAS:2-Cyclohexylethylamine Hydrochloride exhibits inhibitory activity against carbonic anhydrase, suitable for biochemical experiments and drug synthesis research.Formula:C8H18ClNPeso molecolare:163.688CA IX-IN-5
CAIX-IN-5 (compound 9) is an inhibitor of human carbonic anhydrase IX (hCA IX), exhibiting a Ki of 7.4 nM for hCA IX and a Ki of 25.0 nM for hCA II. It effectively inhibits the isoenzymes hCA IX and hCA II, showing higher selectivity for hCA IX than hCA II. CAIX-IN-5 is used in research related to breast cancer, colorectal cancer, glioblastoma, lung cancer, head and neck cancer, and cervical cancer.DOTA-XYIMSR-01
CAS:DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.Formula:C61H88N16O22S2Colore e forma:SolidPeso molecolare:1461.57
