NAMPT
La nicotinamide fosforibosiltransferasi (NAMPT) è un enzima coinvolto nella biosintesi del nicotinamide adenina dinucleotide (NAD+), un coenzima critico nel metabolismo cellulare e nella produzione di energia. Gli inibitori della NAMPT sono di grande interesse nella ricerca sul cancro per la loro capacità di interrompere il metabolismo del NAD+ e indurre la morte cellulare nelle cellule tumorali. Questi inibitori vengono anche studiati nel contesto dei disturbi metabolici e dell'invecchiamento. Presso CymitQuimica, offriamo inibitori della NAMPT per supportare la tua ricerca in biologia del cancro, metabolismo e invecchiamento.
Trovati 39 prodotti per "NAMPT".
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SBI-797812
CAS:SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).Formula:C19H22N4O4SPurezza:99.31%Colore e forma:White SolidPeso molecolare:402.47Nampt-IN-5
CAS:Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Formula:C25H25N5O2Purezza:99.30%Colore e forma:SolidPeso molecolare:427.5Ref: TM-T12171
1mg77,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg250,00€25mg398,00€50mg532,00€100mg735,00€200mg973,00€Nampt activator-1
CAS:NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.Formula:C16H17N3O3Purezza:99.84% - 99.98%Colore e forma:SolidPeso molecolare:299.32ALT-100 (Human IgG1)
ALT-100 (Human IgG1) is a neutralizing mAb targeting eNAMPT used to study the treatment mechanisms of myocardial fibrosis and inflammatory diseases by blocking DAMP signaling.Colore e forma:Odour LiquidNampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.Formula:C27H31Cl3FN5O2Colore e forma:SolidPeso molecolare:582.92Nampt degrader-2
Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.Formula:C59H73N9O7SColore e forma:SolidPeso molecolare:1052.33NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.Formula:C56H74N8O7SPurezza:98%Colore e forma:SolidPeso molecolare:1003.3PROTAC NAMPT Degrader-1
PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.Formula:C57H69N13O8S2Colore e forma:SolidPeso molecolare:1127.48335LYP-8
LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.Formula:C56H74N8O10SColore e forma:SolidPeso molecolare:1050.52486NAMPT activator-7
NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.Formula:C21H17ClN4O3Colore e forma:SolidPeso molecolare:408.09892Nampt-IN-13 FA
Nampt-IN-13 FA is a NAMPT inhibitor (patent WO2021013693A1) suitable for synthesising antibody-drug conjugates (ADCs).Formula:C25H32N6O4Purezza:99.06% - 99.30%Colore e forma:Yellow SolidPeso molecolare:480.56CB 300919
CAS:CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.Formula:C32H34ClN7O2Colore e forma:SolidPeso molecolare:584.11NAMPT Protein, Human, Recombinant (His)
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, butPurezza:94% - 94%Colore e forma:Lyophilized PowderPeso molecolare:55 KDa (reducing condition)Ref: TM-TMPJ-00968
5µg74,00€10µg108,00€20µg164,00€50µg279,00€100µg479,00€200µg827,00€500µg1.710,00€1mg2.457,00€NAT
CAS:NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.Formula:C18H21NO3Purezza:99.65%Colore e forma:White SolidPeso molecolare:299.36Ref: TM-T60667
1mg38,00€5mg74,00€10mg92,00€1mL*10mM (DMSO)93,00€25mg157,00€50mg222,00€100mg329,00€200mg487,00€(E)-Daporinad
CAS:(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.Formula:C24H29N3O2Purezza:98.44% - >99.99%Colore e forma:White SolidPeso molecolare:391.51Ref: TM-T2644
2mg40,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg90,00€25mg178,00€50mg349,00€100mg528,00€500mg1.108,00€Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Formula:C20H25N3O5SPurezza:99.28% - 99.4%Colore e forma:SolidPeso molecolare:419.49Ref: TM-T4376
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg130,00€25mg245,00€50mg409,00€100mg605,00€KPT9274
CAS:KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.Formula:C35H29F3N4O3Purezza:99.75% - 99.93%Colore e forma:SolidPeso molecolare:610.62LB-60-OF61 hydrochloride
CAS:LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.Formula:C29H31ClN6O2Colore e forma:SolidPeso molecolare:531.06CHS-828
CAS:CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Formula:C19H22ClN5OPurezza:98% - 99.9%Colore e forma:White SolidPeso molecolare:371.86STF-118804
CAS:STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Formula:C25H23N3O4SPurezza:99.96%Colore e forma:SolidPeso molecolare:461.53
