PPAR
I recettori attivati dai proliferatori dei perossisomi (PPARs) sono un gruppo di proteine recettori nucleari che funzionano come fattori di trascrizione regolando l'espressione di geni coinvolti nel metabolismo, in particolare lo stoccaggio degli acidi grassi e il metabolismo del glucosio. Gli inibitori dei PPARs sono strumenti importanti per lo studio dei disturbi metabolici come il diabete, l'obesità e le malattie cardiovascolari. Questi inibitori possono modulare il metabolismo dei lipidi, la sensibilità all'insulina e l'infiammazione, rendendoli preziosi nella ricerca terapeutica. Presso CymitQuimica, offriamo una gamma di inibitori dei PPARs per supportare la tua ricerca in malattie metaboliche, endocrinologia e sviluppo di farmaci.
Trovati 172 prodotti per "PPAR".
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Halofenate
CAS:Halofenate is an inhibitor for hypertriglyceridemia, effectively lowering serum triglyceride levels while having minimal impact on serum cholesterol. Additionally, it reduces serum uric acid and promotes uric acid excretion independent of glomerular filtration rate. Halofenate is associated with a significant increase in plasma thyroxine (T4), along with reductions in protein-bound iodine and T4. It can displace T4 from thyroid-binding proteins, which may influence thyroid function in the body.Formula:C19H17ClF3NO4Colore e forma:SolidPeso molecolare:415.79PPARγ agonist 10
CAS:PPARγ agonist 10 (compound 33g) serves as a PPARγ agonist, enhancing insulin secretion, glucose uptake, and insulin sensitivity in βTC6 cells [1].Formula:C17H14N4O3S2Colore e forma:SolidPeso molecolare:386.45PPARγ agonist 17
CAS:PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.Formula:C48H63NO7Colore e forma:SolidPeso molecolare:766.016PPARγ phosphorylation inhibitor 1
CAS:PPARγ phosphorylation inhibitor 1, PPARγ agonist (IC50=24 nM), inhibits CDK5-mediated Ser273 phosphorylation, antidiabetic activity.Formula:C22H14Cl2N2O4Purezza:99.86%Colore e forma:White SolidPeso molecolare:441.26Fonadelpar
CAS:Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.Formula:C25H23F3N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:504.52PPARγ-IN-5
CAS:PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.Formula:C22H23ClO7Colore e forma:SolidPeso molecolare:434.867SR 11023
CAS:SR 11023, an orally active PPAR γ antagonist, exhibits an IC 50 value of 109 nM and is significant in diabetes research [1].Formula:C33H36N2O3Colore e forma:SolidPeso molecolare:508.65PPARα/δ agonist 3
CAS:PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.Formula:C23H25F3N2O4Colore e forma:SolidPeso molecolare:450.451Anti-NASH agent 2
CAS:Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.
Formula:C32H51N3O2Colore e forma:SolidPeso molecolare:509.766PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Formula:C19H15F3N2O3S2Colore e forma:SolidPeso molecolare:440.46Amezalpat
CAS:Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.Formula:C34H41N3O4Colore e forma:White SolidPeso molecolare:555.707Aleglitazar
CAS:Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.Formula:C24H23NO5SPurezza:99.03%Colore e forma:White SolidPeso molecolare:437.51
