FXR
Il recettore X per il farnesoide (FXR) è un recettore nucleare che svolge un ruolo chiave nella regolazione dell'omeostasi degli acidi biliari, del metabolismo lipidico e della regolazione del glucosio. FXR è un potenziale bersaglio terapeutico per il trattamento di malattie epatiche, disturbi metabolici e malattie cardiovascolari. Gli inibitori di FXR possono modulare queste vie, offrendo approfondimenti sui meccanismi delle malattie e sulle strategie terapeutiche. Presso CymitQuimica, offriamo una gamma di inibitori di FXR per supportare la tua ricerca in epatologia, metabolismo e sviluppo di farmaci.
Trovati 67 prodotti per "FXR".
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FXR agonist 3
FXR agonist 3 is an anti NASH compound with anti-fibrotic and active properties that inhibits the expression of COL1A1, TGF-β1, α-SMA and TIMP1.Formula:C28H28BrNO4Purezza:95.04%Colore e forma:Yellow SolidPeso molecolare:521.12Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purezza:99.4% - 99.80%Colore e forma:SolidPeso molecolare:312.4458Tauro-Obeticholic acid
CAS:Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).Formula:C28H49NO6SPurezza:99.74% - 99.82%Colore e forma:SolidPeso molecolare:527.757Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Formula:C24H39NaO4Purezza:99.66% - 99.96%Colore e forma:SolidPeso molecolare:414.5538GW 4064
CAS:GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).Formula:C28H22Cl3NO4Purezza:98% - 99.94%Colore e forma:White SolidPeso molecolare:542.84Obeticholic Acid
CAS:Obeticholic Acid (6-ECDCA, INT-747) is a high-affinity, semisynthetic, bile acid-derived FXR agonist.Cost-effective and quality-assured.Formula:C26H44O4Purezza:99.88% - 99.97%Colore e forma:SolidPeso molecolare:420.6252Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFormula:C6H13Cl2NOPurezza:98%Colore e forma:SolidPeso molecolare:186.08Tropifexor
CAS:Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.Formula:C29H25F4N3O5SPurezza:99.3% - 99.85%Colore e forma:SolidPeso molecolare:603.585Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFormula:C25H24F2N2O3Purezza:98.55% - 99.73%Colore e forma:Yellow SolidPeso molecolare:438.4665BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Formula:C25H44O3Purezza:99.95%Colore e forma:SolidPeso molecolare:392.6151DY268
CAS:DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist.Formula:C30H32N4O5SPurezza:99.43% - 99.75%Colore e forma:SolidPeso molecolare:560.66Nidufexor
CAS:Nidufexor is an agonist for the farnesoid X receptor (FXR).Formula:C27H22ClN3O4Purezza:98.67%Colore e forma:White SolidPeso molecolare:487.934T0901317
CAS:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).Formula:C17H12F9NO3SPurezza:98% - 99.64%Colore e forma:SolidPeso molecolare:481.33Vidofludimus
CAS:Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).Formula:C20H18FNO4Purezza:98.33% - 99.58%Colore e forma:SolidPeso molecolare:355.3596Glyco-Obeticholic acid
CAS:Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).Formula:C28H47NO5Purezza:99.77% - 99.95%Colore e forma:SolidPeso molecolare:477.6765Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Formula:C32H36N2O3Purezza:98.87% - 99.61%Colore e forma:Yellow SolidPeso molecolare:496.64Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formula:C22H34O7Purezza:98.83% - 99.86%Colore e forma:White SolidPeso molecolare:410.50Cilofexor
CAS:Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.Formula:C28H22Cl3N3O5Purezza:99.86% - ≥95%Colore e forma:SolidPeso molecolare:586.85Vonafexor
CAS:Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effectsFormula:C19H15Cl3N2O5SPurezza:98.74%Colore e forma:White SolidPeso molecolare:489.757Teduglutide
CAS:Teduglutide (ALX-0600) is a glucagon-like peptide-2 analog that increases intestinal absorption and can be used in research on short bowel syndrome (SBS).Formula:C164H252N44O55SPurezza:98.08% - 99.29%Colore e forma:White SolidPeso molecolare:3752.08
