Neuroscienza
Gli inibitori in neuroscienze sono composti progettati per modulare l'attività di proteine, enzimi o recettori specifici all'interno del sistema nervoso. Questi inibitori sono cruciali per studiare i meccanismi molecolari alla base della funzione neuronale, della trasmissione sinaptica e delle malattie neurodegenerative. Mirando ai recettori dei neurotrasmettitori, ai canali ionici e alle vie di segnalazione, gli inibitori in neuroscienze aiutano a esplorare la funzione cerebrale e a sviluppare strategie terapeutiche per disturbi neurologici come l'Alzheimer, il Parkinson e l'epilessia. Presso CymitQuimica, offriamo una vasta gamma di inibitori in neuroscienze di alta qualità per supportare la tua ricerca in neurobiologia, neurofarmacologia e scienze cognitive.
Sottocategorie di "Neuroscienza"
- recettore 5-HT(1.025 prodotti)
- ACK(1 prodotti)
- AChR(645 prodotti)
- Citrato liasi ATP(17 prodotti)
- Recettore adrenergico(3.018 prodotti)
- BACE(37 prodotti)
- Beta amiloide(228 prodotti)
- CaMK(73 prodotti)
- COX(600 prodotti)
- Recettore della dopamina(445 prodotti)
- Ricettore GABA(372 prodotti)
- Gamma-secretasi(61 prodotti)
- GluR(265 prodotti)
- GlyT(26 prodotti)
- Recettore dell'istamina(385 prodotti)
- LRRK2(43 prodotti)
- Recettore della melatonina(26 prodotti)
- NMDAR(10 prodotti)
- Recettore OX(41 prodotti)
- Recettore degli oppioidi(327 prodotti)
Mostrare 12 più sottocategorie
Trovati 5514 prodotti di "Neuroscienza"
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NAS-181 free base
CAS:NAS-181 free base is a 5-HT(1B) receptor antagonist.Formula:C19H26N2O4Colore e forma:SolidPeso molecolare:346.42L 663581
CAS:L 663581 is the benzodiazepine receptor partial agonist.Formula:C17H16ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:357.79CP-122288
CAS:CP-122288: potent, selective 5-HT1B/D/F agonist; inhibits plasma protein extravasation, neurogenic inflammation.Formula:C16H23N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:321.44mAChR antagonist 1
CAS:Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes,Formula:C19H22N2O2Colore e forma:SolidPeso molecolare:310.39(2R,4R)-APDC
CAS:(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.Formula:C6H10N2O4Purezza:98%Colore e forma:SolidPeso molecolare:174.15Brasofensine Maleate
CAS:Brasofensine Maleate inhibits the monoamine re-uptake.Formula:C20H24Cl2N2O5Colore e forma:SolidPeso molecolare:443.32Bexicaserin
CAS:Bexicaserin (Compound 3), a 5-HT2C receptor agonist, has potential applications in research pertaining to obesity and psychiatric disorders [1].Formula:C15H19F2N3OColore e forma:SolidPeso molecolare:295.33Amesergide
CAS:Amesergide is an orally active and selective serotonin (5-HT1/2) antagonist that inhibits weight gain in offspring of female CD rats, for depression research.Formula:C25H35N3OPurezza:100% - 99.54%Colore e forma:SolidPeso molecolare:393.56Mesembrine
CAS:Mesembrine is an alkaloid, a 5-HT transporter inhibitor (K i 1.4 nM), and inhibits PDE4B (IC50 7.8 μM).Formula:C17H23NO3Colore e forma:SolidPeso molecolare:289.37MAO-B-IN-1
CAS:MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases.Formula:C16H14F3N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:369.36GYKI-46903 HCl
CAS:GYKI-46903 is a noncompetitive 5-HT3 receptor antagonist.Formula:C17H21ClFNO2Colore e forma:SolidPeso molecolare:325.81LY3202626
CAS:LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.Formula:C22H20F2N8O2SPurezza:98%Colore e forma:SolidPeso molecolare:498.51Brasofensine sulfate
CAS:Brasofensine sulfate is a dopamine reuptake inhibitor.Formula:C16H22Cl2N2O5SColore e forma:SolidPeso molecolare:425.33rel-HDMP 28 hydrochloride
CAS:Rel-HDMP-28 hydrochloride (Compound 2g) is an analogue of methylphenidate, exhibiting selective affinity for the serotonin transporter (SERT) with a binding constant (Ki) of 105 nM [1].Formula:C18H22ClNO2Colore e forma:SolidPeso molecolare:319.83CAY10649
CAS:1CAY10649, a thiazolinone compound, directly inhibits 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with an IC50 value of 0.28 μM and in a soluble fraction of an S100 PMNL cell lysate with an IC50 value of 0.09 μM, following stimulation by calcium and arachidonic acid. This activity highlights its potential in mitigating inflammatory responses by targeting the biosynthesis of leukotrienes, substances implicated in various inflammatory processes such as neutrophil chemotaxis, increased vascular permeability, and smooth muscle contraction.Formula:C17H12ClNO2SColore e forma:SolidPeso molecolare:329.8Wf-516
CAS:Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressantFormula:C25H25Cl2N3O4Purezza:98%Colore e forma:SolidPeso molecolare:502.39BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formula:C18H14F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.33KBR 2822
CAS:KBR 2822 is an inhibitor of esterase.Formula:C9H15ClF3O3PSPurezza:98%Colore e forma:SolidPeso molecolare:326.7JM-1232
CAS:JM-1232 is a sedative and hypnotic drug being researched as a potential anesthetic.Formula:C24H27N3O2Colore e forma:SolidPeso molecolare:389.49Lanabecestat HCl
CAS:Lanabecestat (AZD3293/LY3314814) is a potent oral BACE1 inhibitor that crosses the BBB and reduces Aβ levels.Formula:C26H29ClN4OColore e forma:SolidPeso molecolare:448.995Tiotropium Bromide hydrate
CAS:Tiotropium Bromide hydrate is a potent, long-lasting anticholinergic bronchodilator for COPD, with high affinity for muscarinic receptors M1, M2, and M3.Formula:C19H24BrNO5S2Purezza:98.44% - 99.41%Colore e forma:SolidPeso molecolare:490.43Physostigmine hemisulfate
CAS:cholinesterase inhibitorFormula:C15H21N302H204SPurezza:98%Colore e forma:SolidPeso molecolare:324.393β-Hydroxy-lup-20(29)-en-16-one
CAS:3β-Hydroxy-lup-20(29)-en-16-one (compound 9) serves as a dual inhibitor of both AChE and BChE, displaying a preference for BChE with an IC50 of 28.9 μM [1].Formula:C30H48O2Colore e forma:SolidPeso molecolare:440.7VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Formula:C18H15FN2OPurezza:99.56%Colore e forma:SolidPeso molecolare:294.32β-Secretase Inhibitor IV
CAS:β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).Formula:C31H38N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:578.72DU-125530
CAS:DU-125530 is a 5-HT1A receptor antagonist.Formula:C23H26ClN3O5SColore e forma:SolidPeso molecolare:491.99AChE-IN-44
CAS:AChE-IN-44 (Compound Tap4), an AChE inhibitor, is convertible into its thiazole salt form known as Tat2 [1].Formula:C31H38ClN3OS2Colore e forma:SolidPeso molecolare:568.24Afizagabar
CAS:Afizagabar, a first-in-class α5-GABAAR antagonist, IC50: 585 nM, Ki: 66 nM, may boost memory.Formula:C19H12FN3O2SColore e forma:SolidPeso molecolare:365.38AChE-IN-30
CAS:AChE-IN-30 is an acetylcholinesterase inhibitor (IC50 4.4 μM) that reduces oxidative stress and apoptosis, useful for Alzheimer’s disease research models.Formula:C22H24N4O2Purezza:99.96%Colore e forma:SolidPeso molecolare:376.45mGAT-IN-1
CAS:mGAT-IN-1 is a potent, non-selective GAT inhibitor that inhibits mGAT3 activity well (IC50: 2.5 μM, pIC50: 5.61).Formula:C28H34ClN3O2S2Colore e forma:SolidPeso molecolare:544.17LY 53857
CAS:LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.Formula:C27H36N2O7Colore e forma:SolidPeso molecolare:500.592Biphenylindanone A
CAS:Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.Formula:C30H30O4Purezza:98%Colore e forma:SolidPeso molecolare:454.56Octahydroaminoacridine succinate
CAS:Octahydroaminoacridine succinate, an acetylcholinesterase inhibitor, is used potentially for the treatment of Alzheimer's disease.Formula:C17H24N2O4Purezza:99.91%Colore e forma:SolidPeso molecolare:320.38CGP 54626 hydrochloride
CAS:CGP 54626 hydrochloride is a GABAB receptor antagonist.Formula:C18H29Cl3NO3PPurezza:98%Colore e forma:SolidPeso molecolare:444.76L 687306
CAS:L 687306 is a partial agonist of muscarinic M1 receptors. It is also a highly competitive antagonist at cardiac M2 receptors and ileal M3 muscarinic receptors.Formula:C11H15N3OColore e forma:SolidPeso molecolare:205.26Brasofensine
CAS:Brasofensine, a benztoalkane MA reuptake inhibitor, shows promise for Parkinson's and Alzheimer's.Formula:C16H20Cl2N2OColore e forma:SolidPeso molecolare:327.25SB 258719
CAS:SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.Formula:C18H30N2O2SPurezza:99.73%Colore e forma:SolidPeso molecolare:338.51Ref: TM-T12855
2mg34,00€5mg52,00€10mg85,00€25mg155,00€50mg240,00€100mg355,00€200mg502,00€1mL*10mM (DMSO)58,00€Hydroxy Varenicline
CAS:Hydroxy varenicline, a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline, functions within the biochemical pathway by interacting with nAChR sites.Formula:C13H13N3OColore e forma:SolidPeso molecolare:227.267LY2033298
CAS:LY2033298 enhances oximoline's effect on hamster circadian rhythms, aiding neurosystem disorders.Formula:C13H14ClN3O2SPurezza:98.78%Colore e forma:SolidPeso molecolare:311.79VU6012962
CAS:VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).Formula:C21H19F3N4O4Purezza:99.61% - 99.74%Colore e forma:SolidPeso molecolare:448.4Ref: TM-T13323
1mg34,00€2mg49,00€5mg74,00€10mg119,00€25mg225,00€50mg404,00€100mg592,00€1mL*10mM (DMSO)82,00€NO-711ME
CAS:NO-711ME (N-O711 Methyl ester) is a prodrug of NO-711. It also is a potent and selective GABA uptake inhibitor.Formula:C22H24N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:364.44Ref: TM-T24540
1mg64,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg767,00€1mL*10mM (DMSO)138,00€Adenylyl cyclase-IN-1
CAS:Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1].Formula:C9H8N2S3Colore e forma:SolidPeso molecolare:240.37Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Formula:C24H25ClN4O2Colore e forma:SolidPeso molecolare:436.935-HT2 agonist-1
CAS:Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively.Formula:C19H23ClN2O2Purezza:98%Colore e forma:SolidPeso molecolare:346.85GMA-839
CAS:GMA-839 is a selective modulator of gamma-aminobutyric acid(A) receptors.Formula:C21H31F3O3Purezza:98%Colore e forma:SolidPeso molecolare:388.46SCS
CAS:SCS is a GABAA receptor antagonist.Formula:C14H12N2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:256.263-Bromocytisine
CAS:3-Bromocytisine ((-)-3-Bromocytisine) is an effective agonist of nAChR (IC50s: 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7).Formula:C11H13BrN2OPurezza:99.974%Colore e forma:SolidPeso molecolare:269.14Ref: TM-T10108
1mg95,00€5mg202,00€10mg293,00€25mg494,00€50mg710,00€100mg973,00€200mg1.305,00€1mL*10mM (DMSO)178,00€BACE1-IN-13
CAS:BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (Formula:C20H17FN8O2Purezza:98%Colore e forma:SolidPeso molecolare:420.4MAO-IN-3
CAS:MAO-IN-3 (Compound 5), a reversible and competitive monoamine oxidase (MAO) inhibitor with inhibition constants (K i) of 0.6 μM for MAO A and 0.2 μM for MAO B,Formula:C42H54N4O4Purezza:98%Colore e forma:SolidPeso molecolare:678.95-HT2A&5-HT2C agonist-1
CAS:5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM.Formula:C14H20N2OPurezza:98%Colore e forma:SolidPeso molecolare:232.32(1α,1'S,4β)-Lanabecestat
CAS:(1α,1'S,4β)-Lanabecestat is a Beta site APP Cleaving Enzymel (BACE1) inhibitor, and has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay),Formula:C26H28N4OColore e forma:SolidPeso molecolare:412.53MTPG
CAS:Group II/group III metabotropic glutamate receptor antagonistFormula:C10H11N5O2Purezza:98%Colore e forma:SolidPeso molecolare:233.23BMS-933043
CAS:BMS-933043: α7 nAChR partial agonist, binds rat (Ki=3.3 nM) & human (Ki=8.1 nM), agonist with EC50=23.4 nM (calcium assay), 0.14-0.29 μM (electrophysiology).Formula:C16H19N7OPurezza:98%Colore e forma:SolidPeso molecolare:325.37FGIN-1-27
CAS:FGIN-1-27 is a high-affinity agonist of the translocator protein and a specific peripheral benzodiazepine receptor (PBR) ligand(Ki = 5.0 nM).Formula:C28H37FN2OPurezza:99.86%Colore e forma:SolidPeso molecolare:436.6Capeserod HCl
CAS:Capeserod HCl, a 5-hydroxytriptamine 4 (5-HT4) receptor agonist, is used potentially for the treatment of Alzheimer's disease.Formula:C23H26Cl2N4O4Purezza:98%Colore e forma:SolidPeso molecolare:493.385-HT3 antagonist 1
CAS:5-HT3 antagonist 1 is a potent and selective antagonist of 5-HT3 receptor.Formula:C22H27N5OPurezza:98%Colore e forma:SolidPeso molecolare:377.48R-96544
CAS:R-96544 is an orally active antagonist of the 5-HT2A receptor that has demonstrated the ability to inhibit platelet aggregation in vitro [1].Formula:C22H30ClNO3Colore e forma:SolidPeso molecolare:391.93mGluR5 antagonist-1
CAS:mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].Formula:C23H18N4O2Colore e forma:SolidPeso molecolare:382.41Brilaroxazine
CAS:Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.Formula:C22H25Cl2N3O3Purezza:99.36%Colore e forma:SolidPeso molecolare:450.36Ref: TM-T14782
1mg100,00€5mg236,00€10mg385,00€25mg663,00€50mg954,00€100mg1.305,00€200mg1.738,00€1mL*10mM (DMSO)268,00€Indeloxazine hydrochloride
CAS:Indeloxazine HCl: Serotonin releaser, NE reuptake inhibitor, NMDA antagonist; antidepressant that boosts acetylcholine in rats.Formula:C14H18ClNO2Purezza:98%Colore e forma:SolidPeso molecolare:267.75N-Demethyl MK-6884
CAS:N-Demethyl MK-6884 (compound 34) is an M4 mAChR modulator for Alzheimer's and related disease research.Formula:C24H23N5OColore e forma:SolidPeso molecolare:397.47BMS 433796
CAS:BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.Formula:C21H20F2N4O4Purezza:99.17%Colore e forma:SolidPeso molecolare:430.4BMS-932481
CAS:BMS-932481 is a γ-secretase modulator.Formula:C24H24FN7OColore e forma:SolidPeso molecolare:445.49Tolterodine Dimer
CAS:Tolterodine Dimer is a derivative of Tolterodine -- a muscarinic receptor antagonist that is used to treat patients with overactive bladder.Formula:C35H41NO2Colore e forma:SolidPeso molecolare:507.71CGP36216 hydrochloride
CAS:CGP36216 hydrochloride acts as a selective antagonist at the presynaptic GABA receptor, specifically binding to the GABAB receptor with a Ki value of 0.3 μM. This compound is leveraged in research focused on anxiety and trauma-related disorders [1] [2].Formula:C5H15ClNO2PColore e forma:SolidPeso molecolare:187.6QR-0217
CAS:QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.Formula:C19H13NO3Colore e forma:SolidPeso molecolare:303.31NAD 299 hydrochloride
CAS:Selective, high affinity 5-HT1A receptor antagonistFormula:C18H24ClFN2O2Purezza:98%Colore e forma:SolidPeso molecolare:354.85UNC9994
CAS:UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.Formula:C21H22Cl2N2OSColore e forma:SolidPeso molecolare:421.38GR-127935
CAS:GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist.Formula:C29H31N5O3Colore e forma:SolidPeso molecolare:497.59(S)-Renzapride
(S)-Renzapride (BRL 24924), 5-HT4 agonist (Ki 115 nM), 5HT2b/5HT3 antagonist, for C-IBS study.Formula:C16H22ClN3O2Colore e forma:SolidPeso molecolare:323.82PZ-II-029
CAS:PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.Formula:C18H15N3O3Purezza:99.79%Colore e forma:SolidPeso molecolare:321.33Ref: TM-T28479
1mg50,00€5mg105,00€10mg167,00€25mg289,00€50mg447,00€100mg685,00€500mg1.378,00€1mL*10mM (DMSO)192,00€Bisnorcymserine
CAS:Bisnorcymserine reversibly inhibits butyrylcholinesterase, binding Ser(200) and His(440) non-covalently and stacking with Trp(84).Formula:C21H25N3O2Purezza:98%Colore e forma:SolidPeso molecolare:351.44ABT-418 hydrochloride
CAS:ABT-418 HCl enhances cognition and reduces anxiety as a selective nAChRs agonist, researched for Alzheimer's.Formula:C9H15ClN2OColore e forma:SolidPeso molecolare:202.68JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Formula:C23H25F3N4Colore e forma:SolidPeso molecolare:414.47BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Formula:C26H46BrN5O10P2Colore e forma:SolidPeso molecolare:730.52LY108742
CAS:LY108742 is an antagonist of 5-HT2.Formula:C21H28N2O3Purezza:98%Colore e forma:SolidPeso molecolare:356.46Muscarine tosylate
CAS:Muscarine ((+)-Muscarine) tosylate, a prototype mAChR agonist, serves as a parasympathetic nervous system stimulant and is recognized for its toxic properties [1] [2].Formula:C16H27NO5SColore e forma:SolidPeso molecolare:345.45BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Formula:C26H26F4N4O3Colore e forma:SolidPeso molecolare:518.5YM348
CAS:YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM).Formula:C14H17N3OPurezza:98%Colore e forma:SolidPeso molecolare:243.3LY320954
CAS:LY320954 is an antagonist of 5-HT2A receptor.Formula:C21H26N4O3Purezza:98%Colore e forma:SolidPeso molecolare:382.46PQM130
CAS:PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.Formula:C23H27NO4Purezza:98.73%Colore e forma:SolidPeso molecolare:381.46Serine Hydrolase inhibitor-21
CAS:Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for AlzheimerFormula:C18H12N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:320.37MIN-117
CAS:MIN-117, a SSRI/5-HT receptor antagonist, is potentially used for the treatment of depression.Formula:C25H26Cl3N3O4Purezza:98%Colore e forma:SolidPeso molecolare:538.85FPTQ
CAS:FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].Formula:C17H12FN5Purezza:99.68% - 99.88%Colore e forma:SolidPeso molecolare:305.31Ref: TM-T5509
1mg52,00€2mg70,00€5mg105,00€10mg152,00€25mg294,00€50mg398,00€100mg527,00€500mgPrezzo su richiesta1mL*10mM (DMSO)110,00€Zamifenacin fumarate
CAS:Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.Formula:C31H33NO7Purezza:99.88%Colore e forma:SolidPeso molecolare:531.6Ref: TM-T13385
2mg34,00€5mg50,00€10mg75,00€25mg128,00€50mg200,00€100mg304,00€200mg424,00€1mL*10mM (DMSO)58,00€GABAA receptor agent 2 TFA
CAS:Potent GABAA antagonist; IC50: 24 nM (α1β2γ2), Ki: 28 nM (rat); inactive on human GABA transporters.Formula:C22H22F3N3O3Colore e forma:SolidPeso molecolare:433.425-HT3-In-1
CAS:5-HT3-In-1 (compound example 8) exhabits with 5-HT3 inhibition activity.Formula:C16H21ClN4O3Purezza:98%Colore e forma:SolidPeso molecolare:352.82Velusetrag
CAS:Velusetrag(TD-5108), a potent 5-HT4 agonist, is in development for gastroparesis, constipation, and IBS.Formula:C25H36N4O5SColore e forma:SolidPeso molecolare:504.64BACE1-IN-10
CAS:BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].Formula:C33H49N5O8SPurezza:98%Colore e forma:SolidPeso molecolare:675.84(±)-Fabesetron hydrochloride
CAS:FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.Formula:C18H20ClN3OPurezza:98%Colore e forma:SolidPeso molecolare:329.82Org-21465
CAS:Org-21465, a gamma-aminobutyric acid (GABA) receptor agonist, is used potentially for the use of anesthesia.Formula:C27H43NO4Purezza:98%Colore e forma:SolidPeso molecolare:445.63VU0453595
CAS:VU0453595 is a M1 positive allosteric modulator (PAM).
Formula:C18H15FN4OPurezza:99.91%Colore e forma:SolidPeso molecolare:322.34U 89843A
CAS:U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.Formula:C16H23N5Purezza:99.62%Colore e forma:SolidPeso molecolare:285.39L-822179
CAS:L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.Formula:C17H14N8O2Purezza:98.5% - 99.61%Colore e forma:SolidPeso molecolare:362.35rTRD01
CAS:rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269.Formula:C18H21FN4O2Purezza:99.44%Colore e forma:SolidPeso molecolare:344.38Ref: TM-T81251
1mgPrezzo su richiesta5mg152,00€10mgPrezzo su richiesta25mgPrezzo su richiesta50mg763,00€100mgPrezzo su richiesta13,14-dihydro-15-keto Prostaglandin E2
CAS:13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) serves as the predominant metabolite of PGE2 in plasma, created through a 15-keto PGE2 intermediate by the action of 15-oxo-PG Δ13 reductase. Unlike its precursor PGE2, this compound exhibits poor binding affinity towards EP2 and EP4 PGE2 receptors (Ki values of 12 and 57 µM, respectively) in CHO cells and fails to stimulate adenylate cyclase activity therein (EC50s >18 and >38 µM, respectively). Concentrations of 13,14-dihydro-15-keto PGE2 are notably higher in the plasma of pregnant women during their third trimester and at labor and delivery stages, whereas its levels are found to be reduced in the tumor tissues of patients with non-small cell lung cancer (NSCLC) compared to adjacent healthy tissue.Formula:C20H32O5Colore e forma:SolidPeso molecolare:352.5Zaldaride (free base)
CAS:Zaldaride (free base) is a calmodulin antagonist.Formula:C26H28N4O2Colore e forma:SolidPeso molecolare:428.53CGP-54626 free base
CAS:CGP-54626 is a selective antagonist of the GABAB receptor (IC50 = 4 nM ).Formula:C18H28Cl2NO3PPurezza:98%Colore e forma:SolidPeso molecolare:408.3AAK1-IN-2
CAS:AAK1-IN-2, a potent (IC50=5.8 nM) AAK1 inhibitor, selective & brain-penetrant, is used for neuropathic pain studies.Formula:C20H20N4Colore e forma:SolidPeso molecolare:316.4AAK1-IN-4
CAS:AAK1-IN-4 selectively inhibits AAK1 with IC50 of 4.6 nM; penetrates CNS, oral bioactive, potential for studying neuropathic pain.Formula:C20H28N4O3Colore e forma:SolidPeso molecolare:372.462-Aminotetralin
CAS:2-Aminotetralin acts as a neuromodulatory agent by inhibiting serotonin (5-HT) and norepinephrine reuptake in the rat brain at a dose of 39.4 mg/kg. It triggers hypothermia in rats through intracisternal or intraperitoneal injection, while the implantation of crystals in the hypothalamus' medial preoptic area leads to hyperthermia. Additionally, it mimics (+)-amphetamine in a two-lever drug discrimination test among rats in a dose-dependent manner.Formula:C10H13NColore e forma:SolidPeso molecolare:147.2169RPC425 free base
CAS:RPC425 is a noncompetitive inhibitors of the Betaine-γ-Aminobutyric Acid Transporter 1 (BGT1).Formula:C22H27NO2S2Purezza:98%Colore e forma:SolidPeso molecolare:401.59MK-8768
CAS:MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized byFormula:C21H22F3N5O2Colore e forma:SolidPeso molecolare:433.43Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Formula:C12H19ClN2O7S2Purezza:98.57%Colore e forma:SolidPeso molecolare:402.87Gepirone
CAS:Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs.Formula:C19H29N5O2Purezza:99.35% - 99.89%Colore e forma:SolidPeso molecolare:359.47Abaperidone
CAS:Abaperidone is an atypical antipsychotic, antagonizes 5-HT2A (IC50=6.2 nM) and D2 receptors (IC50=17 nM), reduces hsp70 mRNA in rat brains.Formula:C25H25FN2O5Purezza:99.77%Colore e forma:SolidPeso molecolare:452.47Nemonapride
CAS:Nemonapride is a dopamine D2-like receptor antagonist.Formula:C21H26ClN3O2Purezza:98%Colore e forma:SolidPeso molecolare:387.9FPPQ
CAS:FPPQ blocks 5-HT3 and 5-HT6 receptors (Ki: 0.9 & 3 nM) and may improve psychosis and cognition.Formula:C21H19FN4O2SColore e forma:SolidPeso molecolare:410.46MFZ 10-7
CAS:MFZ 10-7 is anegative allosteric modulator of the mGluR5.Formula:C15H9FN2Purezza:99.80%Colore e forma:SolidPeso molecolare:236.24Flesinoxan HCl
CAS:Flesinoxan HCl is the salt form of Flesinoxan, which is a selective 5-HT1A receptor agonist.Formula:C22H27ClFN3O4Colore e forma:SolidPeso molecolare:451.92CP-409092
CAS:CP-409092 is a partial GABAA receptor agonist. It has anti-anxiety activity.Formula:C17H19N3O2Purezza:98%Colore e forma:SolidPeso molecolare:297.35(-)-Bicuculline methochloride
CAS:(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.
Formula:C21H20ClNO6Purezza:98%Colore e forma:SolidPeso molecolare:417.84MDL-74156
CAS:MDL-74156 is an active metabolite of dolasetron and a 5-hydroxy-tryptamine3 (5-HT3) antagonist.Formula:C19H22N2O3Colore e forma:SolidPeso molecolare:326.39NAS181
CAS:rat 5-HT1B receptor antagonistFormula:C21H34N2O10S2Purezza:98%Colore e forma:SolidPeso molecolare:538.63Timepidium bromide
CAS:Timepidium bromide is an agent of anticholinergic.Formula:C17H22BrNOS2Purezza:98%Colore e forma:SolidPeso molecolare:400.4Osemozotan Free Base
CAS:Osemozotan Free Base is a 5-HT(1A) receptor agonist.Formula:C19H21NO5Colore e forma:SolidPeso molecolare:343.37A-424274
CAS:A-424274 is a positive allosteric modulator of α4β2 neuronal nicotinic receptor.Formula:C14H15N3Purezza:98%Colore e forma:SolidPeso molecolare:225.29Cyanopindolol fumarate
CAS:Cyanopindolol fumarate is a 5-HT receptor antagonist [1].Formula:C16H21N3O2C4H4O4Colore e forma:SolidPeso molecolare:345.4Frovatriptan
CAS:Frovatriptan, potent 5-HT 1B/D agonist, shows high cerebroselectivity and efficacy for migraine with aura.Formula:C14H17N3OPurezza:100%Colore e forma:SolidPeso molecolare:243.3Ref: TM-T60345
1mgPrezzo su richiesta5mgPrezzo su richiesta10mg888,00€25mg1.369,00€50mg1.783,00€100mg2.250,00€PHP 501 trifluoroacetate
CAS:GABAA antagonistFormula:C20H21N3OPurezza:98%Colore e forma:SolidPeso molecolare:319.4LG 50643
CAS:LG 50643 is a muscarinic antagonist.Formula:C24H34INO2Purezza:98%Colore e forma:SolidPeso molecolare:495.44PZ-1190
CAS:PZ-1190, a multitarget ligand for serotonin and dopamine receptors, exhibits potential antipsychotic activity in rodents [1].Formula:C27H30N4O2S2Purezza:98%Colore e forma:SolidPeso molecolare:506.68Lanabecestat camsylate
CAS:Lanabecestat camsylate is used as a BACE1 Inhibitor.Formula:C36H44N4O5SPurezza:98%Colore e forma:SolidPeso molecolare:644.835-HT2C agonist-3 free base
CAS:5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-Formula:C19H22FNO2Purezza:98%Colore e forma:SolidPeso molecolare:315.385-HT2 agonist-1 free base
CAS:Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM,Formula:C19H22N2O2Purezza:98%Colore e forma:SolidPeso molecolare:310.392-Methyl-5-HT
CAS:2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formula:C11H14N2OPurezza:97.18%Colore e forma:SolidPeso molecolare:190.24Ref: TM-T10075
5mg48,00€10mg84,00€25mg177,00€50mg334,00€100mg500,00€500mg1.099,00€1mL*10mM (DMSO)50,00€COR659
CAS:COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Formula:C16H16ClNO3SPurezza:99.75%Colore e forma:SolidPeso molecolare:337.82Ref: TM-T36520
1mg38,00€5mg86,00€10mg123,00€25mg215,00€50mg299,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)94,00€AChE-IN-31
CAS:AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer's disease research [1].Formula:C27H44Na2O9S2Colore e forma:SolidPeso molecolare:622.745-HT2A receptor agonist-3
CAS:5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM.Formula:C21H26BrNO3Purezza:98%Colore e forma:SolidPeso molecolare:420.34AAK1-IN-5
CAS:AAK1-IN-5: Potent, selective AAK1 inhibitor; CNS-penetrant; oral; IC50: 1.2 nM; Ki: 0.05 nM; cell IC50: 0.5 nM. Useful in neuropathic pain research.Formula:C19H23F4N3OColore e forma:SolidPeso molecolare:385.4Quinolactacin A1
CAS:Quinolactacin A1, a strong AChE inhibitor from Penicillium citrinum, aids Alzheimer's research.Formula:C16H18N2O2Colore e forma:SolidPeso molecolare:270.33Flesinoxan
CAS:Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).Formula:C22H26FN3O4Colore e forma:SolidPeso molecolare:415.46Diproqualone
CAS:Diproqualone, analogous to methaqualone, exhibits sedative, anxiolytic, anti-inflammatory, and analgesic properties [1].Formula:C12H14N2O3Colore e forma:SolidPeso molecolare:234.255P11149
CAS:P11149: oral AChE inhibitor, crosses BBB, IC50 1.3 μM, based on Galanthamine, aims Alzheimer's research.Formula:C27H34ClNO4Colore e forma:SolidPeso molecolare:472.02L-772,405
CAS:L-772,405 is a highly selective agonists of h5-HT(1D) receptor.Formula:C26H31FN6OPurezza:98%Colore e forma:SolidPeso molecolare:462.56ADX71441
CAS:ADX71441, a GABAB PAM, lengthens urinary latencies, lessens events & volume, and may aid in alcoholism and bladder pain.Formula:C19H15ClF2N4O4Colore e forma:SolidPeso molecolare:436.8AChE-IN-19
CAS:AChE-IN-19: strong AChE blocker (IC50: 0.56 μM), hinders Aβ clumps, neuro-protective, non-toxic to SH-SY5Y, for Alzheimer's research.Formula:C30H33NO7Colore e forma:SolidPeso molecolare:519.594-Chloro-L-phenylalanine
CAS:4-Chloro-L-phenalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis and a non-specific antagonist of tryptophan hydroxylases (TPH1 and TPH2).Formula:C9H10ClNO2Purezza:99.76% - 99.96%Colore e forma:SolidPeso molecolare:199.63eeAChE-IN-2
CAS:eeAChE-IN-2 is a potent inhibitor of eeAChE, exhibiting inhibitory potency with an IC50 of 2 nM.Formula:C37H40N8O5SColore e forma:SolidPeso molecolare:708.83ASS234
CAS:ASS234 is a multi-target propylamine used in the treatment of Alzheimer's disease.Formula:C29H37N3OColore e forma:SolidPeso molecolare:443.62Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formula:C26H28N4OPurezza:98.55%Colore e forma:SolidPeso molecolare:412.53PNU109291
CAS:PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation.Formula:C24H31N3O3Purezza:98%Colore e forma:SolidPeso molecolare:409.52UNC9994 hydrochloride
CAS:UNC9994 hydrochloride is a selective β-arrestin-biased D2R agonist, Ki of 79 nM, that stimulates β-arrestin and modulates cAMP.Formula:C21H23Cl3N2OSColore e forma:SolidPeso molecolare:457.84VU6004909
CAS:VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.Formula:C21H15FN2O4Purezza:96.68% - 98.44%Colore e forma:SolidPeso molecolare:378.35Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Formula:C24H44Cl2N4O3Purezza:99.75%Colore e forma:SolidPeso molecolare:507.54Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Formula:C18H14FN5OSPurezza:99.21% - 99.77%Colore e forma:SolidPeso molecolare:367.4Ref: TM-T14338
1mg123,00€5mg295,00€10mg477,00€25mg954,00€50mg1.279,00€100mg1.728,00€1mL*10mM (DMSO)326,00€Didesmethyl cariprazine
CAS:Didesmethyl cariprazine, Cariprazine's active metabolite, treats schizophrenia/bipolar with D3/D2 affinity; half-life 1-3 weeks.Formula:C19H28Cl2N4OPurezza:99.52%Colore e forma:SolidPeso molecolare:399.36γ-Secretase-IN-1
CAS:γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Formula:C27H24F2N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:490.5Ref: TM-T3521
1mg120,00€5mg385,00€10mg618,00€25mg1.224,00€50mg1.648,00€100mg2.232,00€1mL*10mM (DMSO)416,00€AMPA receptor modulator-1
CAS:AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Formula:C16H11ClF3NO2Purezza:99.93%Colore e forma:SolidPeso molecolare:341.71R-(+)-EU-1180-453
CAS:R-(+)-EU-1180-453 is a novel GluN2C/D selective NMDAR-positive modulator for the study of neurological disorders.Formula:C22H21FN2O3Purezza:99.63%Colore e forma:SolidPeso molecolare:380.41Tematropium
CAS:Tematropium (CDDD3602) possesses anticholinergic effects and can be used in neurological studies.Formula:C21H31NO8SPurezza:99.89%Colore e forma:SolidPeso molecolare:457.54Ref: TM-T10732
1mg147,00€5mg356,00€10mg558,00€25mg880,00€50mg1.179,00€100mg1.603,00€200mg2.152,00€1mL*10mM (DMSO)413,00€AMPA receptor antagonist-3
CAS:AMPA receptor antagonist-3 is an AMPA receptor antagonist.Formula:C20H19N5O2SPurezza:99.79%Colore e forma:SolidPeso molecolare:393.46Ref: TM-T61813
1mg185,00€5mg425,00€10mg625,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)455,00€BuChE-IN-TM-10
CAS:TM-10: Potent BuChE inhibitor, IC50 8.9 nM, disaggregates Aβ, antioxidant, BBB penetrant, may treat Alzheimer's.Formula:C32H38N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:498.66WAY-607695
CAS:WAY-607695 is a potential 5-HT1A receptor agonist.Formula:C13H12FNO2Purezza:99.82%Colore e forma:SolidPeso molecolare:233.24TZ3O
CAS:TZ3O is an anticholinergic compound with neuroprotective activity.TZ3O ameliorates memory impairment in Scopolamine-induced Alzheimer's type model in rats.Formula:C18H13NO4SPurezza:99.84%Colore e forma:SolidPeso molecolare:339.37Osemozotan HCl
CAS:Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.Formula:C19H22ClNO5Purezza:98.87% - 99.63%Colore e forma:SolidPeso molecolare:379.84SB 216641 hydrochloride
CAS:SB 216641 hydrochloride (SB-216641A) is a 5-HT1B/D receptor antagonist with anxiolytic properties.Formula:C28H31ClN4O4Purezza:98.06% - 99.23%Colore e forma:SolidPeso molecolare:523.02Lumateperone
CAS:Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).Formula:C24H28FN3OPurezza:99.68% - 99.91%Colore e forma:SolidPeso molecolare:393.5BMS-986176
CAS:AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
Formula:C19H23F4N3OPurezza:98.58% - 98.7%Colore e forma:SolidPeso molecolare:385.4PXS-5120A
CAS:PXS-5120A is an irreversible fluoroallylamine Lysyl Oxidase-like 2/3 (LOXL2/3) inhibitor with anti-fibrotic activity.Formula:C22H25ClFN3O4SPurezza:97.02%Colore e forma:SolidPeso molecolare:481.97Ref: TM-T12584
1mg205,00€2mg293,00€5mg462,00€10mg612,00€25mg893,00€50mg1.224,00€100mg1.639,00€1mL*10mM (DMSO)502,00€PXS-5153A
CAS:PXS-5153A rapidly inhibits lysyl oxidase 2/3 enzymes, blocks activity in 15 mins, and reduces fibrosis.Formula:C20H25Cl2FN4O2SPurezza:99.58%Colore e forma:SolidPeso molecolare:475.41SB-616234-A
CAS:SB-616234-A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity.Formula:C32H36ClN5O3Purezza:99.72%Colore e forma:SolidPeso molecolare:574.11MDR-1339
CAS:MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Formula:C20H22O4Purezza:98.57%Colore e forma:SolidPeso molecolare:326.39ZK 93426 hydrochloride
CAS:benzodiazepine receptor antagonist,competitiveFormula:C18H21ClN2O3Purezza:98%Colore e forma:SolidPeso molecolare:348.82γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Colore e forma:Solid(-)-5-HT2C agonist-3
CAS:Compound (−)-19, also known as (-)-5-HT2C agonist-3, is a selective 5-HT2C agonist exhibiting a preference for Gq signaling. It demonstrates efficiency with EC50 values for 5-HT2 receptor subtypes as follows: 5-HT2C at 103 nM, 5-HT2B at 570 nM, and 5-HT2A at 72 nM. This compound is utilized in research on antipsychotics.Formula:C19H23ClFNO2Colore e forma:SolidPeso molecolare:351.84SNRI-IN-1
CAS:SNRI-IN-1 (Compound 7a) acts as a dual inhibitor of serotonin and noradrenaline monoamine reuptake, with a P-glycoprotein Efflux Ratio of 20 [1].Formula:C16H20Cl2N2O2Colore e forma:SolidPeso molecolare:343.25TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Formula:C22H25ClF2N6O3Colore e forma:SolidPeso molecolare:494.92MAO-B-IN-42
CAS:MAO-B-IN-42 (Compound 4f) is a selective and reversible monoamine oxidase-B (MAO-B) inhibitor, with an IC50 value of 0.184 μM. By blocking the oxidative deamination of monoamines catalyzed by MAO-B, it helps maintain neurotransmitter levels. MAO-B-IN-42 shows potential for research into Parkinson's disease.Formula:C19H12FNO2Colore e forma:SolidPeso molecolare:305.302BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).Formula:C29H45N5O7Colore e forma:SolidPeso molecolare:575.7MAO-B-IN-34
CAS:MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.Formula:C15H9Cl2NO3Colore e forma:SolidPeso molecolare:322.14SRI-31255
CAS:SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formula:C15H14N4Colore e forma:SolidPeso molecolare:250.30BMS-901715
CAS:BMS-901715 is an effective and selective inhibitor of adapter protein-2 associated kinase 1 (AAK1; IC50: 3.3 nM).Formula:C22H28N10OPurezza:98%Colore e forma:SolidPeso molecolare:448.52CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.Formula:C14H11ClO4Colore e forma:SolidPeso molecolare:278.69Rodatristat
CAS:Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).Formula:C27H27ClF3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:561.98LP 12 hydrochloride hydrate
LP 12 hydrochloride hydrate: potent, selective 5-HT7 agonist (Ki: 0.13 nM); less affinity for D2, 5-HT1A/2A receptors.Formula:C32H39N3O·HCl·xH2OColore e forma:SolidDSP-1053 benzenesulfonate
CAS:DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Formula:C32H38BrNO7SColore e forma:SolidPeso molecolare:660.62Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Formula:C18H19F3N8OColore e forma:SolidPeso molecolare:420.392Dihydro-β-erythroidine hydrobromide
CAS:Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Formula:C16H22BrNO3Purezza:98%Colore e forma:White SolidPeso molecolare:356.26AChE-IN-8
AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.Formula:C20H22N4O2SColore e forma:SolidPeso molecolare:382.48LY593093
CAS:LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.Formula:C32H30FN3O2Purezza:98%Colore e forma:SolidPeso molecolare:507.6OX2R agonist 1
CAS:OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formula:C21H28F2N2O5SColore e forma:SolidPeso molecolare:458.52BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Formula:C19H15F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:421.35ChEs/MAOs-IN-2
CAS:ChEs/MAOs-IN-2 (compound a11) serves as an inhibitor for both cholinesterases and monoamine oxidases, exhibiting IC 50 values of 0.10 µM for MAO-A, 0.20 µM for MAO-B, 0.30 µM for AChE, and 0.40 µM for BChE. This compound shows promise for Alzheimer's disease research [1].Formula:C15H12N2O3SColore e forma:SolidPeso molecolare:300.33EF1502 free base
CAS:EF1502 is a potent and selective GABA transporter inhibitor.Formula:C22H26N2O2S2Purezza:98%Colore e forma:SolidPeso molecolare:414.58Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Formula:C9H8BF3O2Colore e forma:SolidPeso molecolare:215.965FP0429
CAS:FP0429 is an agonist of mGlu4.Formula:C10H12N2O7Purezza:98%Colore e forma:SolidPeso molecolare:272.212,6-Dimethoxybenzylamine hydrochloride
CAS:2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO) and inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 values of 120 μM and 190 μM, respectively.Formula:C9H14ClNO2Colore e forma:SolidPeso molecolare:203.666MAO-B-IN-44
CAS:MAO-B-IN-44 (Compound 4n) is a selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 1.01 μM, demonstrating weak inhibition of MAO-A (IC50=14.4 μM). It reduces the degradation of neurotransmitters like dopamine and holds potential for research into neurodegenerative diseases such as Parkinson's disease, which are associated with MAO-B abnormalities.Formula:C34H32N4O8Colore e forma:SolidPeso molecolare:624.64BChE-IN-5
BChE-IN-5: potent, selective BChE inhibitor (IC50: 2.8 nM), more effective on hBChE, potential in Alzheimer's research.Formula:C30H42N4OColore e forma:SolidPeso molecolare:474.68AChE-IN-63
CAS:AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 μM. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 μM and 1.342 μM, respectively. AChE-IN-63 is effective in inhibiting Aβ aggregation and preventing the formation and deposition of Aβ1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].Formula:C18H19N5OColore e forma:SolidPeso molecolare:321.38LRRK2-IN-13
CAS:LRRK2-IN-13 (Compound 13), with an IC50 value of 0.57 nM, serves as an inhibitor of LRRK2 and exhibits properties that allow it to penetrate the brain [1].Formula:C19H19ClN8O2Colore e forma:SolidPeso molecolare:426.86Norneostigmine
CAS:Norneostigmine is a potent inhibitor of AChE capable of crossing the blood-brain barrier. When administered to mice, it achieves a 50% inhibition rate of brain AChE activity within 10 minutes, comparable to the effect of Tetrahydroaminoacridine (57% inhibition in 10 minutes). Norneostigmine is applicable in research on Alzheimer's disease and other memory-related disorders.Formula:C11H16N2O2Colore e forma:SolidPeso molecolare:208.26AChE-IN-11
AChE-IN-11 aids Alzheimer's research, has neuroprotection/antioxidant properties (ORAC=2.5), and acts on AChE, MAO-B, BACE1 with IC50 values of 7.9-9.9 μM.Formula:C18H28N2O4Colore e forma:SolidPeso molecolare:336.43LRRK2-IN-14
CAS:LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2(G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].Formula:C17H18F3N5O2Colore e forma:SolidPeso molecolare:381.35(R,R)-LRRK2-IN-7
CAS:(R,R)-LRRK2-IN-7 is an isomer of LRRK2-IN-7, a potent and selective LRRK2 kinase inhibitor with CNS penetrance. It exhibits an IC50 of 0.9 nM and demonstrates over 1000-fold selectivity compared to other kinases, ion channels, and CYP enzymes.Formula:C24H26N6OPeso molecolare:414.50LRRK2-IN-2
CAS:LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formula:C23H23Cl2F3N6O2Colore e forma:SolidPeso molecolare:543.37SEP-363856 mesylate
CAS:SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.Formula:C10H17NO4S2Colore e forma:SolidPeso molecolare:279.38K027
K027 is a potent organophosphate (OP) inhibitor of acetylcholinesterase (AChE) reactivation. k027 can be used to study Alzheimer's disease.Formula:C15H18Br2N4O2Colore e forma:SolidPeso molecolare:446.14nAChR antagonist 1
CAS:Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Formula:C19H22N4O2Colore e forma:SolidPeso molecolare:338.4
