Neuroscienza
Gli inibitori in neuroscienze sono composti progettati per modulare l'attività di proteine, enzimi o recettori specifici all'interno del sistema nervoso. Questi inibitori sono cruciali per studiare i meccanismi molecolari alla base della funzione neuronale, della trasmissione sinaptica e delle malattie neurodegenerative. Mirando ai recettori dei neurotrasmettitori, ai canali ionici e alle vie di segnalazione, gli inibitori in neuroscienze aiutano a esplorare la funzione cerebrale e a sviluppare strategie terapeutiche per disturbi neurologici come l'Alzheimer, il Parkinson e l'epilessia. Presso CymitQuimica, offriamo una vasta gamma di inibitori in neuroscienze di alta qualità per supportare la tua ricerca in neurobiologia, neurofarmacologia e scienze cognitive.
Sottocategorie di "Neuroscienza"
- recettore 5-HT(1.025 prodotti)
- ACK(1 prodotti)
- AChR(645 prodotti)
- Citrato liasi ATP(17 prodotti)
- Recettore adrenergico(3.017 prodotti)
- BACE(37 prodotti)
- Beta amiloide(228 prodotti)
- CaMK(73 prodotti)
- COX(600 prodotti)
- Recettore della dopamina(445 prodotti)
- Ricettore GABA(372 prodotti)
- Gamma-secretasi(61 prodotti)
- GluR(265 prodotti)
- GlyT(26 prodotti)
- Recettore dell'istamina(385 prodotti)
- LRRK2(43 prodotti)
- Recettore della melatonina(26 prodotti)
- NMDAR(10 prodotti)
- Recettore OX(41 prodotti)
- Recettore degli oppioidi(327 prodotti)
Mostrare 12 più sottocategorie
Trovati 5480 prodotti di "Neuroscienza"
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MAO-IN-6
MAO-IN-6 (Compound 3f) is a reversible MAO-B inhibitor that can cross the blood-brain barrier, with an IC50 value of 0.09 μM. It also shows inhibitory activity against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 exhibits low cytotoxicity and is applicable in Alzheimer's disease research.Formula:C22H14F3NO2Colore e forma:SolidPeso molecolare:381.35Mant-GTPγS
CAS:Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.Formula:C18H23N6O14P3SColore e forma:SolidPeso molecolare:672.39(rel)-Asperparaline A
CAS:Aspergillimide, from A. japonicus, inhibits silkworm neuron nAChRs (IC50s: 20.2/39.6 nM), not affecting chicken nAChRs, and paralyzes silkworm larvae.
Formula:C20H29N3O3Colore e forma:SolidPeso molecolare:359.47Fasciculic acid C
CAS:Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formula:C38H63NO11Purezza:98%Colore e forma:SolidPeso molecolare:709.91BMY-14802
CAS:BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Formula:C18H22F2N4OPurezza:99.84%Colore e forma:SoildPeso molecolare:348.39Ref: TM-T67739
2mg35,00€5mg52,00€10mg90,00€25mg164,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€AChE-IN-27
CAS:AChE-IN-27 is a small molecule used for high-throughput assays.Formula:C20H14N2O3Purezza:98.54%Colore e forma:SolidPeso molecolare:330.34AChE-IN-40
AChE-IN-40 (Compound 5C), with an inhibitory concentration 50 (IC50) of 120 nM, is an acetylcholinesterase (AChE) inhibitor suitable for Alzheimer's diseaseFormula:C23H27NO4Colore e forma:SolidPeso molecolare:381.46HDAC6-IN-49
HDAC6-IN-49 (Compound 3) is an inhibitor of HDAC, with IC50 values of 0.012 and 0.735 µM against HDAC6 and HDAC1, respectively. Additionally, it inhibits MAO-B, cholinesterase (ChE), histamine receptor (H3R), and serotonin 6 receptor (5-HT6R). HDAC6-IN-49 exhibits neuroprotective effects in SH-SY5Y cells and enhances cognitive functions and motor abilities in fruit fly models of Parkinson's disease and C. elegans models of Alzheimer's disease.Colore e forma:Odour SolidAChE-IN-86
AChE-IN-86 (Compound 6f) is an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 25.33 μg/mL. This compound exerts its inhibitory effects by forming hydrogen bonds, π-π, and π-alkyl interactions with amino acid residues at the key catalytic site of AChE. AChE-IN-86 can be utilized in Alzheimer's disease research.Formula:C28H27N3O6SColore e forma:SolidPeso molecolare:533.595(Rac)-Sclerone
CAS:(Rac)-Sclerone, a natural product isolated from the green husk of Carya illinoinensis, exhibits significant AChE inhibition activity with an IC50 value of 192.Formula:C10H10O3Colore e forma:SolidPeso molecolare:178.18SB 699551
CAS:SB 699551 is a selective 5-HT5A antagonist (Ki=6.31 nM) that enhances 5-HT neuronal function. It inhibits SERT (Ki=25.12 nM),inhibit breast cancer.Formula:C34H45N3OPurezza:99.83%Colore e forma:SoildPeso molecolare:511.74Ref: TM-T23325L
1mg190,00€5mg471,00€10mg662,00€25mg1.036,00€50mg1.429,00€100mg1.821,00€200mg2.489,00€BChE-IN-10
CAS:BChE-IN-10, a strong mixed BChE inhibitor (IC50=6.4 μM), comes from Bletilla striata for AD research.Formula:C23H20O5Colore e forma:SolidPeso molecolare:376.4Soclenicant
CAS:Soclenicant is a negative-altering modulator of α 7 -nAChR for anxiety, depression, and PTSD, due to its high selectivity, oral availabilityFormula:C24H26N4O3Purezza:99.57%Colore e forma:SoildPeso molecolare:418.49VVZ-149
VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.Colore e forma:SolidOsmanthuside B
CAS:Osmanthuside B, isolated from Pseuderanthemum carruthersii (Seem.) Guill.Formula:C29H36O13Colore e forma:SolidPeso molecolare:592.59Otaplimastat HCl
CAS:Otaplimastat HCl is an MMP inhibitor reducing NMDA-mediated excitotoxicity and oxidative stress, restoring TIMP levels, and protecting vascular permeability.Formula:C28H35ClN6O5Purezza:100%Colore e forma:SoildPeso molecolare:571.07β-Amyloid (22-35)
CAS:β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.Formula:C59H102N16O21SPurezza:98%Colore e forma:SolidPeso molecolare:1403.62Bleformin A
CAS:Bleformin A, a natural BChE inhibitor from Bletilla striata, has a 5.2 μM IC50 and is studied for Alzheimer's research.Formula:C23H20O5Colore e forma:SolidPeso molecolare:376.4Bensultap
CAS:Bensultap is an agricultural chemical typically used as a pesticide.Formula:C17H21NO4S4Purezza:98%Colore e forma:SolidPeso molecolare:431.61RuBi-Nicotine
CAS:Nicotinic receptor agonistFormula:C40H44Cl2N8RuPurezza:98%Colore e forma:SolidPeso molecolare:808.81RAGE antagonist peptide
CAS:RAGE antagonist blocks S100P/A4, HMGB-1; hinders glioma growth, metastasis; reduces PDAC cell growth, NF-κB activity; counters TDI effects in mice.Formula:C57H101N13O17SPurezza:98%Colore e forma:SolidPeso molecolare:1272.56β-Amyloid (12-20)
CAS:β-Amyloid (12-20) is a peptide fragment of β-Amyloid.Thsis peptide contain the amino acid residues VFF at position (18-20), suggesting that this triad hasFormula:C57H83N15O11Purezza:98%Colore e forma:SolidPeso molecolare:1154.36β-Amyloid (22-40)
CAS:This synthetic peptide consists of amino acids 22 to 40 of beta amyloid protein.Formula:C78H135N21O26SPurezza:98%Colore e forma:SolidPeso molecolare:1815.1Peptide 401
CAS:Peptide 401: AMP from bee/wasp venom, triggers histamine release, reduces paw swelling.Formula:C110H192N40O24S4Purezza:98%Colore e forma:SolidPeso molecolare:2587.22p-Xylene bis(pyridinium bromide)
CAS:p-Xylene bis(pyridinium bromide) (compound 21) is a cationic quenching agent and acts as a weak bis-quaternary ammonium salt inhibitor for AChE and BChE, with IC50 values of 1540 μM and 529 μM, respectively.Formula:C18H18Br2N2Colore e forma:SolidPeso molecolare:422.16BuChE-IN-8
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) andFormula:C28H33ClN4O2SColore e forma:SolidPeso molecolare:525.11FFN246
CAS:FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation andFormula:C15H13FN2OPurezza:98%Colore e forma:SolidPeso molecolare:256.27Azocarnil
Azocarnil is a GABAergic agonist-enhancer used in neurological system research.Colore e forma:Odour SolidCytidine 5′-diphosphoethanolamine
CAS:Cytidine 5′-diphosphoethanolamine, a key intermediate in phosphatidylethanolamine synthesis, also serves as a stimulant of Ach synthesis [1].
Formula:C11H20N4O11P2Colore e forma:SolidPeso molecolare:446.24hAChE-IN-6
hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM.Colore e forma:Odour SolidMGS0274
CAS:MGS0274, a lipophilic prodrug of mGlu2/3 agonist MGS0008, enhances oral bioavailability, potentially aiding schizophrenia research.Formula:C21H32FNO7Colore e forma:SolidPeso molecolare:429.485CPN-267
CAS:CPN-267 (compound 7b) acts as a selective agonist for the neuromediatin U receptor 1 (NMUR1), exhibiting an EC50 value of 0.25 nM. It effectively inhibits weight gain in mice, making it useful for obesity research.Formula:C50H66N16O8SColore e forma:SolidPeso molecolare:1051.23Echimidine N-oxide
CAS:Echimidine N-oxide, a pyrrolizidine alkaloid, exhibits significant inhibitory activity against acetylcholinesterase (AChE) with an IC50 value of 0.347 mM.Formula:C20H31NO8Colore e forma:SolidPeso molecolare:413.47BI 1181181 MZ
BI 1181181 MZ is a potent and selective BACE1 inhibitor. BI 1181181 MZ is applicable to Alzheimer's disease research.Formula:C31H37FN4O5Colore e forma:SolidPeso molecolare:564.2748Zicronapine fumarate
CAS:Zicronapine fumarate, an antipsychotic, targets D1/D2 & 5-HT2A receptors; may treat neuropsychiatric conditions.Formula:C26H31ClN2O4Colore e forma:SolidPeso molecolare:470.99AChE/BChE-IN-11
CAS:AChE/BChE-IN-11, natural from artichoke leaves, inhibits AChE and BChE (IC50: 70/71 μM) for Alzheimer's research.Formula:C21H22O12Colore e forma:SolidPeso molecolare:466.39PD25
PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM.Formula:C25H24N2O4Colore e forma:SolidPeso molecolare:416.47SC-53116
CAS:SC-53116 HCl can increase the production of serotonin in central nervous system tissues and is a psychoactive agent.Formula:C16H22ClN3O2Colore e forma:SolidPeso molecolare:323.8212,14-Dichlorodehydroabietic acid
CAS:12,14-Dichlorodehydroabietic acid activates BK channels, blocks GABA A receptors, and increases calcium and neurotransmitter release.Formula:C20H26Cl2O2Colore e forma:SolidPeso molecolare:369.33Fipronil sulfone
CAS:Fipronil sulfone is an insecticide fipronil. Its metabolite fipronil sulphone is an inhibitor of rat ɑ1β2γ2L GABA(A) receptor.Formula:C12H4Cl2F6N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:453.14Lycoramine hydrobromide
CAS:Lycoramine is a natural alkaloid isolated from Lycoris chinensis.Formula:C17H24BrNO3Colore e forma:SolidPeso molecolare:370.28Galanin (1-15) (porcine, rat)
CAS:N-terminal galanin fragment used to mediate central cardiovascular effectsFormula:C72H105N19O20Purezza:98%Colore e forma:SolidPeso molecolare:1556.72NPS ALX Compound 4a hydrochloride(1:1)
NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.Formula:C25H26ClN3O2SPurezza:99.84%Colore e forma:SoildPeso molecolare:468.01Ref: TM-T12262L1
1mg38,00€5mg84,00€10mg113,00€25mg188,00€50mg273,00€100mg371,00€200mg494,00€1mL*10mM (DMSO)92,00€TET-13
TET-13 is a positive allosteric modulator of the GABAA receptor with an EC50 of 5.65 μM, which is more potent than Etomidate (EC50: 9.29 μM). It exhibits strong anesthetic effects in both mice and rats, with an ED50 of 0.48 mg/kg in mice and 0.69 mg/kg in rats.Formula:C15H16N2O3SColore e forma:SolidPeso molecolare:304.36TC-2216
CAS:TC-2216 is a partial agonist at the neural nicotinic acetylcholine receptor and is used to treat anxiety and depression.Formula:C12H17N3Purezza:99.81%Colore e forma:SolidPeso molecolare:203.28Tranylcypromine
CAS:Tranylcypromine (SKF 385), a potent monoamine oxidase (MAO) inhibitor [1], is used in medicinal applications.Formula:C9H11NPurezza:98%Colore e forma:SolidPeso molecolare:133.19JPC0323
JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequateFormula:C22H43NO4Purezza:98%Colore e forma:SolidPeso molecolare:385.58Chrodrimanin B
CAS:Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.Formula:C27H32O8Colore e forma:SolidPeso molecolare:484.545Olanzapine Lactam Impurity
CAS:Olanzapine lactam impurity, found in olanzapine, forms under heat or oxidative stress.Formula:C17H20N4O2Colore e forma:SolidPeso molecolare:312.373BChE-IN-39
BChE-IN-39 (Compound 7c) selectively inhibits butyrylcholinesterase (BChE) with an IC50 of 0.08 μM, while showing an IC50 of 3.98 μM for acetylcholinesterase (AChE) inhibition. Additionally, BChE-IN-39 downregulates GSK-3β expression, thereby inhibiting the excessive phosphorylation of tau protein.Formula:C29H23ClFN3O3Colore e forma:SolidPeso molecolare:515.963
