Proteasoma
Gli inibitori del proteasoma sono composti che inibiscono il proteasoma, un grande complesso proteico responsabile della degradazione delle proteine non desiderate o danneggiate all'interno della cellula. L'inibizione del proteasoma porta all'accumulo di proteine, che può indurre l'arresto del ciclo cellulare e l'apoptosi, in particolare nelle cellule che si dividono rapidamente, come le cellule tumorali. Gli inibitori del proteasoma sono fondamentali nella ricerca e nella terapia del cancro, specialmente nel trattamento del mieloma multiplo e di altre neoplasie ematologiche. Presso CymitQuimica, offriamo inibitori del proteasoma per supportare la tua ricerca in oncologia, biologia cellulare e sviluppo di farmaci.
Trovati 95 prodotti di "Proteasoma"
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Trelagliptin
CAS:Trelagliptin (SYR-472) is a highly specific and long-acting DPP-4 inhibitor.Formula:C18H20FN5O2Purezza:98.88%Colore e forma:SolidPeso molecolare:357.38Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Formula:C17H27N3O7SPurezza:99.2% - 99.64%Colore e forma:White CrystalPeso molecolare:417.48Saxagliptin hydrate
CAS:Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Formula:C18H25N3O2·H2OPurezza:99.52%Colore e forma:SolidPeso molecolare:333.43Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Formula:C18H24ClN3O7Purezza:99.44% - 99.98%Colore e forma:SolidPeso molecolare:429.85UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFormula:C15H12F4N4O2Purezza:98.12%Colore e forma:SolidPeso molecolare:356.27Ref: TM-T13273
1mg52,00€5mg119,00€10mg187,00€25mg354,00€50mg533,00€100mg825,00€1mL*10mM (DMSO)131,00€Sitagliptin
CAS:Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.Formula:C16H15F6N5OPurezza:99.33% - 99.83%Colore e forma:Yellow GreasePeso molecolare:407.31RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Formula:C19H13Cl4NOPurezza:98.89% - 99.38%Colore e forma:SolidPeso molecolare:413.12Gly-Pro-pNA hydrochloride
CAS:<p>Gly-Pro-pNA hydrochloride (Gly-Pro p-nitroanilide hydrochloride) is a dipeptidyl peptidase inhibitor that inhibits dipeptidyl peptidase II, dipeptidyl peptidase</p>Formula:C13H17ClN4O4Purezza:99.84%Colore e forma:SolidPeso molecolare:328.75ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Formula:C17H24BF3N2O4Purezza:97.06%Colore e forma:SolidPeso molecolare:388.19Ref: TM-T12079
1mg115,00€2mg166,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€200mg1.825,00€1mL*10mM (DMSO)301,00€Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purezza:96.74% - 99.94%Colore e forma:SolidPeso molecolare:685.89DBPR108
CAS:DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.Formula:C16H25FN4O2Purezza:99.68%Colore e forma:SolidPeso molecolare:324.39Ref: TM-T15079
1mg50,00€5mg105,00€10mg140,00€25mg226,00€50mg324,00€100mg437,00€200mg605,00€1mL*10mM (DMSO)116,00€RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Formula:C28H23Cl5N2O2Purezza:97.7%Colore e forma:SolidPeso molecolare:596.76Ref: TM-T13858
1mg57,00€5mg115,00€10mg168,00€25mg245,00€50mg437,00€100mg642,00€1mL*10mM (DMSO)150,00€Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Colore e forma:SolidPeso molecolare:696.92Procizumab
Procizumab is a humanized IgG1 antibody that targets dipeptidyl peptidase 3 (DPP3). It shows potential for investigating sepsis. For the isotype control, refer to HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidDazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purezza:99.11%Colore e forma:SolidPeso molecolare:395.38Ref: TM-T9710
1mg96,00€5mg202,00€10mg305,00€25mg550,00€50mg772,00€100mg1.074,00€1mL*10mM (DMSO)224,00€Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColore e forma:SolidPeso molecolare:909.06Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SPeso molecolare:3175.65874VAMP
<p>VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.</p>Formula:C18H32N4O5SColore e forma:SolidPeso molecolare:416.535Acetyl-Calpastatin(184-210)(human)
CAS:Calpain inhibitor, Ki 0.2 nM for calpain I/II, doesn't affect papain/trypsin/cat L. Raises Aβ42, Aβ40 secretion & Aβ42/Aβ40 ratio.Formula:C142H230N36O44SPurezza:98%Colore e forma:SolidPeso molecolare:3177.65Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidRef: TM-L1100
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPhepropeptin B
CAS:Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.Formula:C40H56N6O6Colore e forma:SolidPeso molecolare:716.91LXE408 fumarate
<p>LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.</p>Formula:C27H22FN7O6Purezza:99.89%Colore e forma:SoildPeso molecolare:559.51PROTAC 20S proteasome subunit β5 degrader 2
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.Colore e forma:Odour Solidβ5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM.Purezza:98%Colore e forma:Odour SolidPhepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Formula:C41H58N6O6Colore e forma:SolidPeso molecolare:730.94Bortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Colore e forma:Odour SolidDPP-4-IN-14
<p>DPP-4-IN-14 (compound 30) is an inhibitor of DPP-4, with an IC50 value of 12.82 nM.</p>Formula:C33H27N7O3Colore e forma:SolidPeso molecolare:569.613DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Colore e forma:Odour SolidPhepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Formula:C37H58N6O6Colore e forma:SolidPeso molecolare:682.89Cerpegin
CAS:Cerpegin, a pyridine ketone fused c-lactone, acts as an inhibitor of the 20S proteasome. It possesses pharmacological properties as a neuropsychiatric sedative, anti-inflammatory, analgesic, and exhibits anti-ulcer activity.Formula:C10H11NO3Colore e forma:SolidPeso molecolare:193.2Acetyl-Calpastatin(184-210)(human) TFA
Acetyl-Calpastatin(184-210)(human) TFA inhibits μ-calpain (Ki 0.2 nM) and cathepsin L (Ki 6 μM) selectively and reversibly.Formula:C144H231F3N36O46SColore e forma:SolidPeso molecolare:3291.65LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formula:C16H27BN4O3Colore e forma:SoildPeso molecolare:334.22H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Formula:C13H22F3N3O5Colore e forma:SolidPeso molecolare:357.335-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurezza:99.69%Colore e forma:SolidPeso molecolare:160.17Alogliptin (13CD3)
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Formula:C18H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:343.4Teneligliptin D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Formula:C22H30N6OSPurezza:98%Colore e forma:SolidPeso molecolare:434.63VR23
CAS:<p>VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.</p>Formula:C19H16ClN5O6SPurezza:98.99% - 99.22%Colore e forma:SolidPeso molecolare:477.8818α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Formula:C30H46O4Purezza:98.54% - 99.68%Colore e forma:SolidPeso molecolare:470.68TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Formula:C39H37N3O3Purezza:98.2% - 98.75%Colore e forma:SolidPeso molecolare:595.73Ref: TM-T17011
1mg74,00€5mg160,00€10mg250,00€25mg455,00€50mg682,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)205,00€Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Formula:C20H23BCl2N2O9Purezza:98.37% - >99.99%Colore e forma:SolidPeso molecolare:517.12MG-132
CAS:<p>MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor, cell-permeable and reversible,an autophagy activator, induces apoptosis. High-Quality, Low-Cost!</p>Formula:C26H41N3O5Purezza:95% - 99.99%Colore e forma:White To Off-White PowderPeso molecolare:475.62Alloxan monohydrate
CAS:<p>Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.</p>Formula:C4H4N2O5Purezza:99.01% - 99.42%Colore e forma:Off-White To Beige-Yellowish Crystalline PowderPeso molecolare:160.09ARV-471
CAS:<p>ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.</p>Formula:C45H49N5O4Purezza:97.15% - >99.99%Colore e forma:SolidPeso molecolare:723.9Omarigliptin
CAS:Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. Cost-effective and quality-assured.Formula:C17H20F2N4O3SPurezza:99.68% - 99.77%Colore e forma:SolidPeso molecolare:398.43Ref: TM-T2316
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg212,00€50mg350,00€100mg505,00€500mg1.121,00€1mL*10mM (DMSO)138,00€Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Formula:C20H30N2O4Purezza:97.06% - 98.33%Colore e forma:White To Off-White PowderPeso molecolare:362.46Talabostat mesylate
CAS:<p>Talabostat mesylate (PT100): Oral DPP4 inhibitor, IC50 0.18 nM, targets tumor-linked proteins, boosts hematopoiesis.</p>Formula:C10H23BN2O6SPurezza:98% - 99.91%Colore e forma:SolidPeso molecolare:310.18PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.474'-Hydroxychalcone
CAS:<p>4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity</p>Formula:C15H12O2Purezza:99.86% - 99.87%Colore e forma:Yellow-Cream PowderPeso molecolare:224.25ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purezza:98.24% - 99.31%Colore e forma:SolidPeso molecolare:580.67Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purezza:97.79% - >99.99%Colore e forma:Yellow SolidPeso molecolare:384.24Ref: TM-T2399
5mg52,00€10mg64,00€25mg80,00€50mg96,00€100mg144,00€200mg225,00€500mg373,00€1mL*10mM (DMSO)52,00€
