Cisteina proteasi
Gli inibitori delle proteasi a cisteina sono composti che mirano e inibiscono le proteasi a cisteina, una classe di enzimi che degradano le proteine rompendo i legami peptidici in cui un residuo di cisteina agisce come nucleofilo. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui l'apoptosi, la risposta immunitaria e il turnover proteico. Gli inibitori delle proteasi a cisteina sono cruciali per lo studio di malattie come il cancro, i disturbi neurodegenerativi e le infezioni parassitarie. Presso CymitQuimica, offriamo inibitori delle proteasi a cisteina per supportare la tua ricerca in proteolisi, regolazione cellulare e scoperta di farmaci.
Trovati 110 prodotti di "Cisteina proteasi"
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PMSF
CAS:PMSF (Phenylmethylsulfonyl fluoride) is an irreversible inhibitor of serine/cysteine protease , preparation of cell lysates. High-Quality, Low-Cost!Formula:C7H7FO2SPurezza:97.75% - 99.88%Colore e forma:White To Cream SolidPeso molecolare:174.19Z-Leu-Tyr-Chloromethylketone
CAS:Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].Formula:C24H29ClN2O5Colore e forma:SolidPeso molecolare:460.95N-CBZ-Phe-Arg-AMC TFA
N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.Formula:C35H37F3N6O8Purezza:99.88%Colore e forma:SolidPeso molecolare:726.7Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Formula:C85H122N22O19Colore e forma:SolidPeso molecolare:1756.046Z-Arg-Arg-βNA acetate
CAS:<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Formula:C32H43N9O6Colore e forma:SolidPeso molecolare:649.74Gallinamide A TFA
CAS:<p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>Formula:C33H53F3N4O9Colore e forma:SolidPeso molecolare:706.79Z-Phe-Tyr(tBu)-diazomethylketone
CAS:Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.Formula:C31H34N4O5Colore e forma:SolidPeso molecolare:542.636Z-FG-NHO-Bz
CAS:Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].Formula:C26H25N3O6Colore e forma:SolidPeso molecolare:475.49Hepcidin-1 (mouse)
CAS:Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.Formula:C111H169N31O35S8Colore e forma:SolidPeso molecolare:2754.24N-CBZ-Phe-Arg-AMC
CAS:Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.Formula:C33H36N6O6Purezza:98%Colore e forma:White To Off-White PowderPeso molecolare:612.68Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidCathepsin C-IN-6
Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastaseFormula:C24H35N5O4·xC2HF3O2Colore e forma:SolidLeupeptin
CAS:Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.Formula:C20H38N6O4Purezza:98%Colore e forma:SolidPeso molecolare:426.562Relacatib
CAS:Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.Formula:C27H32N4O6SColore e forma:SolidPeso molecolare:540.64Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Colore e forma:Odour Solid6,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Formula:C30H42N2O4SColore e forma:SolidPeso molecolare:526.73Z-L(D-Val)G-CHN2
Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.Formula:C22H31N5O5Purezza:98%Colore e forma:SolidPeso molecolare:445.51VK13
VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.Formula:C24H28N4O5Colore e forma:SolidPeso molecolare:452.503FGA139
<p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>Formula:C48H58BF2N7O5Colore e forma:SolidPeso molecolare:861.45605Cathepsin L-IN-3
CAS:<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Formula:C41H49N7O4SColore e forma:SolidPeso molecolare:735.94
