Cellule staminali e Derivati
Gli inibitori delle cellule staminali sono composti che bersagliano specificamente le vie di segnalazione e le proteine coinvolte nel mantenimento, nella differenziazione e nella proliferazione delle cellule staminali. Questi inibitori sono cruciali per comprendere la biologia delle cellule staminali e per sviluppare strategie per manipolare le cellule staminali a fini terapeutici, come la medicina rigenerativa e il trattamento del cancro. Controllando il destino delle cellule staminali, questi inibitori possono aiutare a guidare la differenziazione delle cellule staminali in tipi cellulari specifici o a prevenire una crescita cellulare indesiderata. Presso CymitQuimica, offriamo una selezione di inibitori delle cellule staminali di alta qualità per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e medicina rigenerativa.
Sottocategorie di "Cellule staminali e Derivati"
- Gamma-secretasi(59 prodotti)
- Proteina Hedgehog/Smoothened(44 prodotti)
- Via di segnalazione Hippo(6 prodotti)
- JAK(245 prodotti)
- Proteina Porcupine(9 prodotti)
- ROCK(70 prodotti)
- STAT(98 prodotti)
- Cellule staminali(486 prodotti)
- TGF-beta/Smad(58 prodotti)
- Wnt/beta-catenina(66 prodotti)
Mostrare 2 più sottocategorie
Trovati 695 prodotti di "Cellule staminali e Derivati"
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JAK-IN-14
CAS:<p>JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.</p>Formula:C19H15FN4OPurezza:98.27%Colore e forma:SolidPeso molecolare:334.35OICR-0547
CAS:<p>OICR-0547 is an inactive derivative of OICR-9429 and is commonly used as a negative control for OICR-9429.</p>Formula:C28H29F3N4O4Purezza:98%Colore e forma:SolidPeso molecolare:542.55EP009
CAS:<p>EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies.</p>Formula:C14H24O2Colore e forma:SolidPeso molecolare:224.34Tyk2-IN-7
CAS:<p>Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).</p>Formula:C18H15D3N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:401.463F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purezza:98.14% - 98.25%Colore e forma:SolidPeso molecolare:286.28MS-1020
CAS:<p>MS-1020 inhibits JAK3/STAT3, blocks active JAK3, suppresses JAK3/STAT5 signaling, and targets STAT3 in certain cells.</p>Formula:C21H18N2O3Purezza:98%Colore e forma:SolidPeso molecolare:346.381,2,3,4,5,6-Hexabromocyclohexane
CAS:<p>Inhibits JAK2 autophosphorylation; non-cytotoxic at 100μM; 1μM reduces activity by 50%, 50μM nearly abolishes it.</p>Formula:C6H6Br6Purezza:98%Colore e forma:SolidPeso molecolare:557.54INCB16562
CAS:<p>INCB16562: oral JAK1/2 inhibitor, halts IL-6/STAT3 in myeloma cells, boosts drug efficacy, stunts myeloma in mice.</p>Formula:C19H11Cl2N5Colore e forma:SolidPeso molecolare:380.23JAK3-IN-9
CAS:<p>JAK3-IN-9, potent JAK3 inhibitor, IC50 of 1.7 nM, highly selective, low toxicity, orally bioavailable, shows anti-arthritis activity.</p>Formula:C17H23N5O4SColore e forma:SolidPeso molecolare:393.46RR-11a analog
CAS:<p>RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).</p>Formula:C22H29N5O8Purezza:98.80%Colore e forma:SolidPeso molecolare:491.49TGFβRI-IN-1
CAS:<p>TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,</p>Formula:C20H14D3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:362.4JAK-IN-20
CAS:<p>JAK-IN-20: potent oral JAK1,2,3 inhibitor with IC50s 7, 5, 14 nM respectively, good pharmacokinetics, anti-inflammatory in vivo.</p>Formula:C28H30FN7O2Colore e forma:SolidPeso molecolare:515.58Aβ42-IN-1 free base
CAS:<p>Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091</p>Formula:C29H26N4O2Purezza:98%Colore e forma:SolidPeso molecolare:462.54JAK-2/3-IN-2
CAS:<p>JAK-2/3-IN-2 (Compound 3h) is a potent JAK2 & JAK3 inhibitor with IC50s of 23.85 nM (JAK2) & 18.9 nM (JAK3).</p>Formula:C19H19ClN2OSColore e forma:SolidPeso molecolare:358.89Peficitinib hydrochloride
CAS:<p>Peficitinib HCl (ASP015K) is an oral JAK inhibitor with IC50s: JAK1 (3.9 nM), JAK2 (5.0 nM), JAK3 (0.7 nM), Tyk2 (4.8 nM).</p>Formula:C18H23ClN4O2Colore e forma:SolidPeso molecolare:362.86BPN-15606
CAS:<p>BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.</p>Formula:C23H23FN6OColore e forma:SolidPeso molecolare:418.47RR-11a
CAS:<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Formula:C24H28N6O10Purezza:98%Colore e forma:SolidPeso molecolare:560.51TK4b
CAS:<p>TK4b, a JAK inhibitor, targets leukemia/lymphoid diseases, with IC50s: 18.42 nM (JAK3) & 19.40 nM (JAK2).</p>Formula:C21H22N2O2Colore e forma:SolidPeso molecolare:334.41TUL01101
CAS:<p>TUL01101, a selective oral JAK1 inhibitor (IC50: 3 nM), also targets JAK2, JAK3, TYK2; for rheumatoid arthritis research.</p>Formula:C22H25F2N5O2Colore e forma:SolidPeso molecolare:429.46γ-Secretase modulator 11
CAS:<p>5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and</p>Formula:C28H22F2N4O2Colore e forma:SolidPeso molecolare:484.5CP-690550A
CAS:<p>Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.</p>Formula:C15H21N5O2Colore e forma:SolidPeso molecolare:303.36GDC-4379
CAS:<p>GDC-4379 is a JAK1 inhibitor that can be used to study asthma.</p>Formula:C21H18ClF2N7O3Colore e forma:SolidPeso molecolare:489.86Povorcitinib
CAS:<p>Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).</p>Formula:C23H22F5N7OColore e forma:SolidPeso molecolare:507.469(2R,5S)-Ritlecitinib
CAS:<p>(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].</p>Formula:C15H19N5OColore e forma:SolidPeso molecolare:285.34TYK2-IN-11
CAS:<p>TYK2-IN-11 (5B) selectively inhibits TYK2 (IC50: 0.016 nM) and JAK1 (IC50: 0.31 nM), aiding autoimmune and inflammatory disease research.</p>Formula:C18H17N5O3SColore e forma:SolidPeso molecolare:383.42Yhhu-3792
CAS:<p>Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.</p>Formula:C24H24N4O2Colore e forma:SolidPeso molecolare:400.47Thi-DPPY
CAS:<p>Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.</p>Formula:C28H28ClN5O4SColore e forma:SolidPeso molecolare:566.07Peficitinib hydrobromide
CAS:<p>Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.</p>Formula:C18H23BrN4O2Colore e forma:SolidPeso molecolare:407.312PF-00956980
CAS:<p>PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.</p>Formula:C18H26N6OColore e forma:SolidPeso molecolare:342.44SYK/JAK-IN-1
CAS:<p>SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2.</p>Formula:C24H26N8O3Colore e forma:SolidPeso molecolare:474.52JA310
CAS:<p>JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].</p>Formula:C17H19N7OColore e forma:SolidPeso molecolare:337.38ELN318463 racemate
CAS:<p>ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.</p>Formula:C19H20BrClN2O3SPurezza:99.69%Colore e forma:SolidPeso molecolare:471.8Wnt pathway activator 2
CAS:<p>Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.</p>Formula:C17H15NO4Purezza:99.41%Colore e forma:SolidPeso molecolare:297.31JAK3-IN-1
CAS:<p>JAK3-IN-1 is an orally active, selective and potent JAK3 inhibitor for the study of immune system disorders.</p>Formula:C26H30ClN7O2Colore e forma:SolidPeso molecolare:508.02β-catenin/CBP-IN-1
CAS:<p>β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin</p>Formula:C33H35N6O7PPurezza:98%Colore e forma:SolidPeso molecolare:658.64JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Formula:C20H18FN5O3SPurezza:99.53%Colore e forma:SolidPeso molecolare:427.45CK2-IN-4
CAS:<p>CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.</p>Formula:C18H11N3O4SPurezza:99.72%Colore e forma:SolidPeso molecolare:365.36JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Formula:C25H28N8OPurezza:97.89%Colore e forma:SolidPeso molecolare:456.54inS3-54-A26
CAS:<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formula:C25H19ClN2O2Purezza:99.57%Colore e forma:SolidPeso molecolare:414.88CAY10746
CAS:<p>CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.</p>Formula:C26H23N3O5Purezza:99.04%Colore e forma:SolidPeso molecolare:457.48TEAD-IN-6
CAS:<p>TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].</p>Formula:C19H17F3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:438.42JAK-IN-28
CAS:<p>JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].</p>Formula:C20H18ClN7OPurezza:98%Colore e forma:SolidPeso molecolare:407.86JAK-IN-30
CAS:<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Formula:C19H26N8SPurezza:98%Colore e forma:SolidPeso molecolare:398.53PIMPC
CAS:<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formula:C21H19N5OPurezza:98%Colore e forma:SolidPeso molecolare:357.41Aβ42-IN-2
CAS:<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Formula:C24H26N6O2Purezza:98.09% - 99.87%Colore e forma:SolidPeso molecolare:430.5Chromenone 1
CAS:<p>Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).</p>Formula:C18H10F3N3O2Purezza:99.83% - 99.93%Colore e forma:SolidPeso molecolare:357.29JAK1-IN-4
CAS:<p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>Formula:C26H32FN9O2Purezza:98%Colore e forma:SolidPeso molecolare:521.59JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Formula:C25H32N8O2Purezza:99.64% - 99.87%Colore e forma:SolidPeso molecolare:476.57Lorpucitinib
CAS:<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Formula:C22H28N6O2Purezza:99.72%Colore e forma:SolidPeso molecolare:408.5JAK3i
CAS:<p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>Formula:C18H15FN4O3Purezza:98.61% - 99.81%Colore e forma:SolidPeso molecolare:354.34
