Cellule staminali
Gli inibitori delle cellule staminali sono composti che mirano specificamente alle cellule staminali e alle loro vie di segnalazione, influenzando la loro capacità di autorinnovarsi e differenziarsi. Questi inibitori sono cruciali nella ricerca focalizzata sul controllo del comportamento delle cellule staminali, sulla comprensione dei processi di sviluppo e sullo sviluppo di terapie per malattie come il cancro, dove si ritiene che le cellule staminali svolgano un ruolo chiave. Presso CymitQuimica, offriamo una varietà di inibitori delle cellule staminali per supportare la tua ricerca in medicina rigenerativa, biologia dello sviluppo e oncologia.
Trovati 467 prodotti di "Cellule staminali"
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Tyk2-IN-20
CAS:Tyk2-IN-20 (Example 289) is an effective inhibitor of Tyk2 with an IC50 value below 5 nM. Additionally, it inhibits JAK1, JAK2, and JAK3 with IC50 values under 100 nM. This compound is utilized for the research of inflammatory diseases.Formula:C24H25N7O2Colore e forma:SolidPeso molecolare:443.50YLIU-4-105-1
CAS:YLIU-4-105-1 is a type II JAK2 inhibitor. Demonstrating in vivo pharmacological activity, YLIU-4-105-1 reduces splenic weight, decreases blood reticulocyte counts in a dose-dependent manner, and inhibits pSTAT5.Formula:C32H34F3N7O2Colore e forma:SolidPeso molecolare:605.65Londamocitinib
CAS:Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formula:C28H31F2N7O4SPurezza:98.64% - 99.56%Colore e forma:SolidPeso molecolare:599.65Cenacitinib
CAS:Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Formula:C19H19F2N7O3Colore e forma:SolidPeso molecolare:431.40dCK1α-2
<p>dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.</p>Formula:C24H24ClN5O4Colore e forma:SolidPeso molecolare:481.93CDD-1431
CAS:<p>CDD-1431 is a highly selective BMPR2 kinase inhibitor with a Kiapp of 20.6 nM. It inhibits BRE reporter gene activity, exhibiting an IC50 of 4.87 μM. BMPs regulate cellular processes across various tissue types such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Formula:C33H38N8O5SColore e forma:SolidPeso molecolare:658.77YAP/TAZ inhibitor-3
CAS:YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Formula:C21H18F3NO3Purezza:99.63%Colore e forma:SolidPeso molecolare:389.37TEAD-IN-10
CAS:<p>TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].</p>Formula:C15H14F3NOColore e forma:SolidPeso molecolare:281.27TGFβ1-IN-1
CAS:TGFβ1-IN-1 is a TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in cancer research.Formula:C22H24N2O3Purezza:99.89% - 99.89%Colore e forma:SolidPeso molecolare:364.438GSK-3β inhibitor 20
CAS:<p>GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.</p>Formula:C22H21N5O2SColore e forma:SolidPeso molecolare:419.50CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formula:C19H15F3N4O2Purezza:99.74%Colore e forma:SolidPeso molecolare:388.34AZ-3
CAS:AZ-3 is a potent and selective JAK1 inhibitor (IC50: 34 nM).Formula:C20H28FN7Purezza:98%Colore e forma:SolidPeso molecolare:385.48(Rac)-SAG
CAS:(Rac)-SAG, an isoform of SAG, is a potent Smoothened (Smo) receptor agonist (EC₅₀ = 3 nM; Kd = 59 nM) that activates the Hedgehog signaling pathway and counteracts Cyclopamine's inhibition of Smo [1] [2] [3].Formula:C28H28ClN3OSColore e forma:SolidPeso molecolare:490.06STAT3-IN-35
CAS:<p>STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.</p>Formula:C21H23NO4Colore e forma:SolidPeso molecolare:353.41TEAD-IN-1
CAS:<p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>Formula:C15H20F2N2O3SColore e forma:SolidPeso molecolare:346.393TEAD-IN-20
CAS:TEAD-IN-20 is a TEAD inhibitor with IC50 values of 0.021 μM in TEAD4 FRET and 0.044 μM in TEAD4 MCF7-Tead cell lines. It has potential applications in cancer research.Formula:C20H19F3N4O3Colore e forma:SolidPeso molecolare:420.39M3686
CAS:M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formula:C21H18F3N5O2Colore e forma:SolidPeso molecolare:429.395AJI-214
CAS:AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD).Formula:C17H13ClFN5OColore e forma:SolidPeso molecolare:357.77MGD-28
CAS:MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.Formula:C33H34FN7O3Purezza:99.39%Colore e forma:SolidPeso molecolare:595.67CP-352664
CAS:<p>CP-352664 is a JAK inhibitor with potency against JAK3, exhibiting an EC50 value of 210 nM. It holds potential for use in research related to organ transplant rejection and autoimmune diseases, such as rheumatoid arthritis.</p>Formula:C18H18N4Colore e forma:SolidPeso molecolare:290.36
