ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 124 prodotti di "ALK"
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ALK-IN-5
CAS:ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Formula:C24H25FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:464.49ALK2-IN-5
CAS:ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Formula:C24H32N8O2Colore e forma:SolidPeso molecolare:464.56WY-135
CAS:WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).Formula:C28H34ClN9O3SPurezza:98%Colore e forma:SolidPeso molecolare:612.15ALK5-IN-29
CAS:<p>ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.</p>Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51XST-14
CAS:XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.Formula:C16H21NO4Purezza:99.84% - 99.84%Colore e forma:SolidPeso molecolare:291.34ALK5-IN-30
CAS:ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51CJ-2360
CAS:CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.Formula:C27H30FN5O2Colore e forma:SolidPeso molecolare:475.56J-1048
CAS:J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formula:C23H17FN6S2Colore e forma:SolidPeso molecolare:460.55ALK-IN-22
CAS:ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.Formula:C24H24ClN7O2Colore e forma:SolidPeso molecolare:477.95RIPK2-IN-1
CAS:RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).Formula:C23H27N5O3SColore e forma:SolidPeso molecolare:453.56Con B-1
CAS:ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Formula:C38H52ClN7O6SColore e forma:SolidPeso molecolare:770.38SMU-B
CAS:<p>SMU-B is a well-tolerated c-Met/ALK dual inhibitor.</p>Formula:C26H25Cl2FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:515.41Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formula:C29H39N7O3SColore e forma:SolidPeso molecolare:565.73TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Formula:C31H35ClF2N8O2SColore e forma:SolidPeso molecolare:657.18KRCA-0713
CAS:KRCA-0713 is a ALK inhibitor.Formula:C26H32ClN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:530.08ALK2-IN-2
CAS:ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Formula:C28H27N5O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:497.61OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formula:C16H15ClN4O2Purezza:99.45%Colore e forma:SolidPeso molecolare:330.77EML4-ALK kinase inhibitor 1
CAS:<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Formula:C31H48N8O3Purezza:99.62%Colore e forma:SolidPeso molecolare:580.76OD36 hydrochloride
CAS:OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFormula:C16H16Cl2N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:367.23Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formula:C32H45N9O3SPurezza:98.12% - 99.54%Colore e forma:SolidPeso molecolare:635.82
