Recettore Trk
Gli inibitori dei recettori Trk prendono di mira le chinasi recettoriali della tropomiosina (Trk), una famiglia di tirosina chinasi recettoriali che svolgono un ruolo significativo nello sviluppo e nella funzione del sistema nervoso. I recettori Trk sono coinvolti nella segnalazione delle neurotrofine, essenziale per la sopravvivenza, la differenziazione e la crescita dei neuroni. La disregolazione della segnalazione Trk è associata a disturbi neurologici e ad alcuni tipi di cancro. Presso CymitQuimica, offriamo inibitori dei recettori Trk per supportare la tua ricerca in neurobiologia, oncologia e malattie neurodegenerative.
Trovati 56 prodotti di "Recettore Trk"
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Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurezza:97% - 99.94%Colore e forma:Crystals White To Off-White PowderPeso molecolare:313.86CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Formula:C24H22Cl2N6O3Purezza:98.99% - 99.23%Colore e forma:SolidPeso molecolare:513.38N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Formula:C12H14N2O2Purezza:98.31% - 99.91%Colore e forma:SolidPeso molecolare:218.25Adimanebart
CAS:Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Colore e forma:LiquidAnti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Colore e forma:Odour LiquidCRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Colore e forma:Odour LiquidProtein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
Formula:C29H35F2N7O6SPurezza:98%Colore e forma:SolidPeso molecolare:647.69GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formula:C25H27ClFN7Purezza:98.97%Colore e forma:SolidPeso molecolare:479.98TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formula:C16H13N3O5Peso molecolare:327.08552PF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purezza:98%Colore e forma:SolidPeso molecolare:528.49LOXO-195
CAS:(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.Formula:C20H21FN6OPurezza:99.54%Colore e forma:SolidPeso molecolare:380.42Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurezza:99.55% - ≥95%Colore e forma:SolidPeso molecolare:380.42DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.75%Colore e forma:SolidPeso molecolare:735.8Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formula:C26H21F3N4O4Purezza:99.67% - 99.75%Colore e forma:SolidPeso molecolare:510.46GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formula:C28H21F4N5O2Purezza:97.26% - 98.08%Colore e forma:SolidPeso molecolare:535.49Ref: TM-T6097
5mg48,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€1mL*10mM (DMSO)52,00€Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.61%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).
Formula:C15H21N3O6Purezza:99.56%Colore e forma:SolidPeso molecolare:339.34Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormula:C26H29Cl4FN6O3Purezza:98.73%Colore e forma:SolidPeso molecolare:634.36Ref: TM-T22324
1mg59,00€5mg127,00€10mg188,00€25mg404,00€50mg645,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)170,00€CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formula:C32H31N3O5SPurezza:99.92%Colore e forma:SolidPeso molecolare:569.67Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formula:C21H22F2N6O2Purezza:99.15% - >99.99%Colore e forma:SolidPeso molecolare:428.44Ref: TM-T5995
1mg37,00€5mg74,00€10mg90,00€25mg157,00€50mg236,00€100mg356,00€500mg820,00€1mL*10mM (DMSO)81,00€
