Ricettore TAM
Gli inibitori dei recettori TAM prendono di mira la famiglia di recettori tirosina chinasi TAM, che comprende Tyro3, Axl e Mer. Questi recettori sono coinvolti nella regolazione delle risposte immunitarie, della sopravvivenza cellulare e della clearance delle cellule apoptotiche. La disregolazione dei recettori TAM è implicata nel cancro, nelle malattie autoimmuni e nelle infiammazioni croniche. Presso CymitQuimica, offriamo inibitori dei recettori TAM per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 31 prodotti per "Ricettore TAM".
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TAM-IN-2
CAS:TAM-IN-2 is an inhibitor of TAM.Formula:C31H27F2N7O3Purezza:98.09% - 99.74%Colore e forma:SolidPeso molecolare:583.588Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formula:C31H29FN4O5Purezza:99.95% - 99.98%Colore e forma:SolidPeso molecolare:556.5842UNC2250
CAS:UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).Formula:C24H36N6O2Purezza:98.57% - 99.87%Colore e forma:SolidPeso molecolare:440.5816UNC2881
CAS:UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.Formula:C25H33N7O2Purezza:98.97% - 99.85%Colore e forma:SolidPeso molecolare:463.5752SGI-7079
CAS:SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.Formula:C26H26FN7Purezza:95.51% - 99.26%Colore e forma:SolidPeso molecolare:455.5299LDC1267
CAS:LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).Formula:C30H26F2N4O5Purezza:99.38% - 99.88%Colore e forma:SolidPeso molecolare:560.548Cabozantinib hydrochloride
CAS:Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6Formula:C28H25ClFN3O5Purezza:99.97%Colore e forma:White SolidPeso molecolare:537.967UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Formula:C24H34FN7O2Purezza:98.33%Colore e forma:White SolidPeso molecolare:471.57092-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Formula:C15H10O5Purezza:98.58% - 99.45%Colore e forma:Yellow SolidPeso molecolare:270.2369Bemcentinib
CAS:Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.Formula:C30H34N8Purezza:97% - 99.8%Colore e forma:SolidPeso molecolare:506.6446RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurezza:98.87%Colore e forma:SolidPeso molecolare:480.46UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5043BMS 777607
CAS:BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.Formula:C25H19ClF2N4O4Purezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:512.893Cabozantinib
CAS:Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).Formula:C28H24FN3O5Purezza:99.82% - 99.89%Colore e forma:SolidPeso molecolare:501.51NPS-1034
CAS:NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Formula:C31H23F2N5O3Purezza:98.48%Colore e forma:SolidPeso molecolare:551.5428XL092
CAS:XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.Formula:C29H25FN4O5Purezza:98.60%Colore e forma:SolidPeso molecolare:528.531CEP-40783
CAS:CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).Formula:C31H26F2N4O6Purezza:99.76% - 99.84%Colore e forma:White SolidPeso molecolare:588.5581Ningetinib Tosylate
CAS:Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formula:C38H37FN4O8SPurezza:99.93%Colore e forma:SolidPeso molecolare:728.786ONO-7475
CAS:ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinaseFormula:C32H26N4O6Purezza:98.74%Colore e forma:White SolidPeso molecolare:562.572DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.75%Colore e forma:SolidPeso molecolare:735.7999
