c-Kit
Gli inibitori di c-Kit sono composti che bloccano l'attività del Recettore del Fattore di Cella Staminale (c-Kit), una tirosina chinasi che svolge un ruolo cruciale nella sopravvivenza, proliferazione e differenziazione cellulare, in particolare nelle cellule ematopoietiche. Le mutazioni di c-Kit sono associate a vari tipi di cancro, tra cui i tumori stromali gastrointestinali (GIST) e la leucemia. Presso CymitQuimica, offriamo inibitori di c-Kit per supportare la tua ricerca in oncologia, ematologia e biologia delle cellule staminali.
Trovati 116 prodotti per "c-Kit".
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Telatinib
CAS:Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.Formula:C20H16ClN5O3Purezza:97.61% - 99.81%Colore e forma:SolidPeso molecolare:409.83Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormula:C21H18FN5OPurezza:98% - 98.24%Colore e forma:White SolidPeso molecolare:375.4Ref: TM-T2514
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg119,00€50mg178,00€100mg259,00€200mg477,00€500mg772,00€GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formula:C21H23N7O2S·HClPurezza:99.87%Colore e forma:SolidPeso molecolare:473.98N-Desethylsunitinib hydrochloride
CAS:N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.Formula:C20H24ClFN4O2Purezza:99.42%Colore e forma:SolidPeso molecolare:406.88JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formula:C29H29N7O2Purezza:99.24% - >99.99%Colore e forma:White SolidPeso molecolare:507.59Ref: TM-T2668
2mg44,00€5mg73,00€1mL*10mM (DMSO)82,00€10mg113,00€25mg197,00€50mg326,00€100mg482,00€200mg685,00€SU14813
CAS:SU14813: inhibits multiple kinases (VEGFR2, VEGFR1, PDGFRβ, KIT) with IC50s of 50, 2, 4, 15 nM; antiangiogenic and antitumor.Formula:C23H27FN4O4Purezza:98.13%Colore e forma:Yellow SolidPeso molecolare:442.48CP-673451
CAS:CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than otherFormula:C24H27N5O2Purezza:99.62% - 99.88%Colore e forma:Yellow SolidPeso molecolare:417.5Ref: TM-T6091
1mg49,00€2mg63,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg170,00€25mg334,00€50mg512,00€100mg737,00€500mg1.521,00€KI8751
CAS:KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Formula:C24H18F3N3O4Purezza:99.22% - 99.9%Colore e forma:SolidPeso molecolare:469.41Ref: TM-T2446
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg81,00€25mg147,00€50mg279,00€100mg447,00€200mg635,00€Ripretinib
CAS:Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.Formula:C24H21BrFN5O2Purezza:99.07% - 99.62%Colore e forma:White SolidPeso molecolare:510.36Ref: TM-T8482
1mg71,00€2mg92,00€5mg157,00€1mL*10mM (DMSO)170,00€10mg260,00€25mg409,00€50mg615,00€100mg862,00€c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.Colore e forma:White Lyophilized PowderPeso molecolare:58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-00805
5µg94,00€10µg138,00€20µg220,00€50µg434,00€100µg732,00€200µg1.324,00€500µg2.925,00€Toceranib
CAS:Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formula:C22H25FN4O2Purezza:97.62%Colore e forma:SolidPeso molecolare:396.46Briquilimab
CAS:Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.Purezza:96.0% (SDS-PAGE); 96.0% (SEC-HPLC) - 96.0% (SDS-PAGE); 96.0% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.56 KDaBarzolvolimab
CAS:Barzolvolimab (CDX 0159) is a humanized monoclonal antibody targeting KIT that reduces skin mast cells and disease activity in chronic inducible urticaria.Purezza:95% - 95.6% (SDS-PAGE); 95.4% (SEC-HPLC)Colore e forma:Transparent LiquidPeso molecolare:144.63 kDaAnti-Mouse CD117 Antibody
Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.Purezza:98%Colore e forma:Odour LiquidDovitinib Dilactic Acid
CAS:Dovitinib dilactic acid: multitarget RTK inhibitor for FLT3/c-Kit (IC50=1-2 nM), FGFR1/3, VEGFR1-4 (IC50=8-13 nM), less effective on InsR, EGFR. Phase 4.Formula:C21H21FN6O·2C3H6O3Purezza:98%Colore e forma:SolidPeso molecolare:572.59AC710
CAS:AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).Formula:C31H42N6O4Purezza:99.67%Colore e forma:SolidPeso molecolare:562.7Sitravatinib malate
CAS:Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5Formula:C37H35F2N5O9SPurezza:98%Colore e forma:SolidPeso molecolare:763.76GW694590A
CAS:GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].Formula:C22H19N5O4Colore e forma:SolidPeso molecolare:417.42c-Kit-IN-3
CAS:c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).Formula:C26H20ClF3N2O4Purezza:99.94%Colore e forma:SolidPeso molecolare:516.9Ref: TM-T10651
1mg82,00€5mg154,00€10mg240,00€1mL*10mM (DMSO)316,00€25mg396,00€50mg532,00€100mg745,00€500mg1.494,00€APcK110
CAS:"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."Formula:C20H16FN3O2Colore e forma:SolidPeso molecolare:349.36
