c-Kit
Gli inibitori di c-Kit sono composti che bloccano l'attività del Recettore del Fattore di Cella Staminale (c-Kit), una tirosina chinasi che svolge un ruolo cruciale nella sopravvivenza, proliferazione e differenziazione cellulare, in particolare nelle cellule ematopoietiche. Le mutazioni di c-Kit sono associate a vari tipi di cancro, tra cui i tumori stromali gastrointestinali (GIST) e la leucemia. Presso CymitQuimica, offriamo inibitori di c-Kit per supportare la tua ricerca in oncologia, ematologia e biologia delle cellule staminali.
Trovati 116 prodotti per "c-Kit".
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KBP-7018
CAS:KBP-7018 is a selective TKI targeting c-KIT, RET, and PDGFR for mechanistic studies of fibrotic signaling and kinase-driven diseases.Formula:C31H30N4O5Purezza:99.73%Colore e forma:Yellow SolidPeso molecolare:538.59c-Kit-IN-2
CAS:c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (Formula:C25H29N9O2SPurezza:98.95%Colore e forma:White SolidPeso molecolare:519.62Bezuclastinib
CAS:Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.Formula:C19H17N5OPurezza:99.55%Colore e forma:SolidPeso molecolare:331.37KI-328
CAS:KI-328: novel selective KIT kinase inhibitor; blocks Wt/mutant-KIT cell growth; low effect on D816V-KIT.Formula:C25H25N7O3Colore e forma:SolidPeso molecolare:471.51Tafetinib
CAS:Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.Formula:C24H29FN4O2Purezza:96.23%Colore e forma:SolidPeso molecolare:424.51Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formula:C27H21N3O3Purezza:99.22%Colore e forma:SolidPeso molecolare:435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€Agerafenib hydrochloride
CAS:Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Formula:C24H23ClF3N5O5Purezza:98%Colore e forma:SolidPeso molecolare:553.92Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Formula:C20H16FN5O2Purezza:99.95%Colore e forma:SolidPeso molecolare:377.37Ref: TM-T79851
1mg88,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg306,00€25mg610,00€50mg880,00€100mg1.179,00€N-desmethyl Regorafenib N-oxide
CAS:N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Formula:C20H13ClF4N4O4Colore e forma:SolidPeso molecolare:484.79SIM010603
CAS:SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Formula:C22H25FN4O2Colore e forma:SolidPeso molecolare:396.46Henatinib
CAS:Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Formula:C25H29FN4O4Colore e forma:SolidPeso molecolare:468.52Protein kinase inhibitor 10
CAS:Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Formula:C14H9FN6S2Colore e forma:SolidPeso molecolare:344.39AMG-25
CAS:AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Formula:C23H17N5O2Purezza:98.16%Colore e forma:Yellow SolidPeso molecolare:395.41c-Kit-IN-8
CAS:C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Formula:C24H26FN5O4Colore e forma:SolidPeso molecolare:467.49c-Kit-IN-7
CAS:c-Kit-IN-7 (compound 104) serves as an effective inhibitor of c-Kit, exhibiting an IC50 of 10 nM or less. It plays a crucial role in cancer research.Formula:C27H32FN7O3Colore e forma:SolidPeso molecolare:521.59KBP-7018 HCl
CAS:KBP-7018 Hydrochloride is a novel, tyrosine kinase-selective inhibitor with potent effects on three fibrotic kinases (c-KIT, PDGFR, and RET).Formula:C31H31ClN4O5Colore e forma:SolidPeso molecolare:575.06Ref: TM-T70382
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