Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 82 prodotti di "Ubiquitinazione"
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UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Formula:C20H15ClN2O5SColore e forma:SolidPeso molecolare:430.86Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ubiquitin ligase Cbl, demonstrating an IC50 of 15 nM. Cbl-b refers to Casitas B-lineage Lymphoma proto-oncogene-b, which can inhibit the activation of T cells, natural killer (NK) cells, and B cells. Cbl-b-IN-15 can activate T cell function with an EC50 of 0.41 μM.Formula:C27H27N5O3Peso molecolare:469.21139MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Formula:C29H29F3N2Colore e forma:SolidPeso molecolare:462.55CYM5442
CAS:CYM5442 is an S1P agonist, targeting to Sphingosine.Formula:C23H27N3O4Purezza:98.02% - 99.48%Colore e forma:SolidPeso molecolare:409.48NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Formula:C27H28N4O3S2Purezza:99.05% - 99.85%Colore e forma:SolidPeso molecolare:520.67ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Formula:C23H24N4OPurezza:98%Colore e forma:SolidPeso molecolare:372.46PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Formula:C7H5N5S2Purezza:97.25% - >99.99%Colore e forma:SolidPeso molecolare:223.28DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formula:C15H9N5OPurezza:98.96%Colore e forma:SolidPeso molecolare:275.26Ref: TM-T11111
1mg74,00€5mg163,00€10mg245,00€25mg494,00€50mg720,00€100mg1.045,00€1mL*10mM (DMSO)172,00€ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purezza:99.87% - 99.96%Colore e forma:SolidPeso molecolare:384.48VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purezza:98.53% - 99.91%Colore e forma:SolidPeso molecolare:469.39Ref: TM-T4067
1mg96,00€2mg155,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€1mL*10mM (DMSO)265,00€COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Formula:C25H25NO5Purezza:99.23%Colore e forma:SolidPeso molecolare:419.47Ref: TM-T5199
1mg170,00€5mg371,00€10mg537,00€25mg964,00€50mg1.333,00€100mg1.882,00€1mL*10mM (DMSO)409,00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purezza:96.59% - 98.2%Colore e forma:SolidPeso molecolare:348.4Ref: TM-T4634
1mg81,00€5mg170,00€10mg273,00€25mg525,00€50mg753,00€100mg1.026,00€1mL*10mM (DMSO)187,00€WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.
Formula:C21H22N2O2Purezza:98.57%Colore e forma:SolidPeso molecolare:334.41MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formula:C12H11N3O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurezza:98.33% - 98.96%Colore e forma:SolidPeso molecolare:337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purezza:97.9% - 99.64%Colore e forma:SolidPeso molecolare:315.32BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Formula:C23H29N3O5SPurezza:99.15% - 99.94%Colore e forma:SolidPeso molecolare:459.56Ref: TM-T8564
1mg81,00€5mg170,00€10mg250,00€25mg505,00€50mg730,00€100mg1.018,00€200mg1.369,00€1mL*10mM (DMSO)240,00€CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Formula:C24H23N5O2Purezza:95.95% - 99.92%Colore e forma:SolidPeso molecolare:413.47Ref: TM-T6796
1mg43,00€2mg56,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€1mL*10mM (DMSO)92,00€ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurezza:99.3%Colore e forma:SolidPeso molecolare:291.84Ref: TM-T8931L
5mg34,00€10mg50,00€25mg90,00€50mg138,00€100mg198,00€200mg296,00€500mg469,00€1mL*10mM (DMSO)34,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Formula:C23H25ClN4OPurezza:99.91% - 99.96%Colore e forma:SolidPeso molecolare:408.92
