Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 97 prodotti di "Ubiquitinazione"
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Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formula:C27H32N4OPurezza:98%Colore e forma:SolidPeso molecolare:428.57Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].
Formula:C29H30F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:537.58Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Formula:C31H37F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:566.66USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:425.91Ref: TM-T13268
1mg97,00€5mg188,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.130,00€1mL*10mM (DMSO)217,00€IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurezza:99.3%Colore e forma:SolidPeso molecolare:381.43UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormula:C19H18N2OSPurezza:99.3%Colore e forma:SolidPeso molecolare:322.42BC-1293
CAS:BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formula:C26H28N4O4SPurezza:98.40%Colore e forma:SolidPeso molecolare:492.59Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Formula:C21H19F3N6Colore e forma:SolidPeso molecolare:412.41USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formula:C41H43N7O4SPurezza:98%Colore e forma:SolidPeso molecolare:729.89SPOP-IN-2
CAS:SPOP-IN-2 (Compound E1) is a potent inhibitor of speckle-type POZ protein (SPOP), with an IC50 of 0.58 μM. It disrupts the interaction between SPOP and substrates and selectively inhibits the proliferation of clear cell renal cell carcinoma (ccRCC).Formula:C15H13ClN2O5SPeso molecolare:368.79p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Colore e forma:SolidPeso molecolare:413.47PRC1-IN-1
CAS:PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.
Formula:C24H19ClFN3O2Colore e forma:SolidPeso molecolare:435.878DCN1-UBC12-IN-4
CAS:DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 (IC₅₀ > 10 μM), applicable for investigating cancer cell migration and invasion.Formula:C8H6ClN3SPurezza:98.32%Colore e forma:SolidPeso molecolare:211.67Cbl-b-IN-3
CAS:Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Formula:C30H34F3N5OPurezza:97.63%Colore e forma:SolidPeso molecolare:537.62Ref: TM-T63790
1mg70,00€5mg154,00€10mg202,00€25mg384,00€50mg590,00€100mg944,00€1mL*10mM (DMSO)175,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).
Formula:C22H23N3O3Purezza:99.509% - 99.81%Colore e forma:SolidPeso molecolare:377.44USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
Formula:C19H20ClN3O5SPurezza:99.76%Colore e forma:SoildPeso molecolare:437.9
