Ubiquitinazione
Gli inibitori dell'ubiquitinazione sono composti che interferiscono con il processo di ubiquitinazione, in cui le proteine vengono etichettate con molecole di ubiquitina per essere degradate dal proteasoma. Questi inibitori sono fondamentali per studiare il turnover delle proteine, la trasduzione del segnale e la regolazione di vari processi cellulari. L'ubiquitinazione svolge un ruolo chiave in molte malattie, tra cui il cancro, i disturbi neurodegenerativi e le disfunzioni del sistema immunitario. Modulando l'ubiquitinazione, questi inibitori possono fornire approfondimenti sui meccanismi delle malattie e aprire nuove strade per l'intervento terapeutico. Presso CymitQuimica, offriamo un'ampia selezione di inibitori dell'ubiquitinazione di alta qualità per supportare la tua ricerca in biologia cellulare, proteomica e sviluppo di farmaci.
Sottocategorie di "Ubiquitinazione"
Trovati 82 prodotti di "Ubiquitinazione"
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FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Formula:C10H8O4SPeso molecolare:224.23DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Formula:C19H13BrClNO5SPurezza:99.17%Colore e forma:SolidPeso molecolare:482.73Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFormula:C24H29ClN6O2Purezza:98%Colore e forma:SolidPeso molecolare:468.98USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurezza:98.84% - 99.59%Colore e forma:SolidPeso molecolare:368.41P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Formula:C24H24N6OPurezza:97.66%Colore e forma:SoildPeso molecolare:412.49USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purezza:99.37%Colore e forma:SolidPeso molecolare:338.41Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFormula:C31H35F5N6OPurezza:98%Colore e forma:SolidPeso molecolare:602.64PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.
Formula:C14H7ClFN3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:351.67LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurezza:97.12%Colore e forma:SolidPeso molecolare:314.32Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Formula:C21H14F3N3O2SPurezza:98.396% - 99.88%Colore e forma:SolidPeso molecolare:429.42Ref: TM-T13244
5mg66,00€10mg90,00€25mg165,00€50mg264,00€100mg395,00€500mg888,00€1mL*10mM (DMSO)73,00€CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Formula:C20H21Cl2NO6Purezza:99.03%Colore e forma:SolidPeso molecolare:442.29UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Formula:C30H32F2N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:594.68Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Formula:C29H30F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:537.58Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Formula:C31H37F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:566.66Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFormula:C30H33F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:566.62Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100
Formula:C28H29F3N6O2Purezza:98%Colore e forma:SolidPeso molecolare:538.56Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFormula:C29H31F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:557.58Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Formula:C27H32N4OPurezza:98%Colore e forma:SolidPeso molecolare:428.57Cbl-b-IN-8
CAS:Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Formula:C35H44F3N7O3Purezza:98%Colore e forma:SolidPeso molecolare:667.76Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Formula:C30H32F5N5OPurezza:98%Colore e forma:SolidPeso molecolare:573.6UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFormula:C19H18N2OSPurezza:99.3%Colore e forma:SolidPeso molecolare:322.42Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Formula:C21H19F3N6Colore e forma:SolidPeso molecolare:412.41DCN1-UBC12-IN-4
CAS:DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 (IC₅₀ > 10 μM), applicable for investigating cancer cell migration and invasion.Formula:C8H6ClN3SPurezza:98.32%Colore e forma:SolidPeso molecolare:211.67SPOP-IN-2
CAS:SPOP-IN-2 (Compound E1) is a potent inhibitor of speckle-type POZ protein (SPOP), with an IC50 of 0.58 μM. It disrupts the interaction between SPOP and substrates and selectively inhibits the proliferation of clear cell renal cell carcinoma (ccRCC).Formula:C15H13ClN2O5SPeso molecolare:368.79p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Formula:C25H26N6O2Colore e forma:SolidPeso molecolare:442.51VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Formula:C24H23N5O2Colore e forma:SolidPeso molecolare:413.47BC-1293
CAS:BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.Formula:C26H28N4O4SPurezza:98.40%Colore e forma:SolidPeso molecolare:492.59PRC1-IN-1
CAS:PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.Formula:C24H19ClFN3O2Colore e forma:SolidPeso molecolare:435.878Cbl-b-IN-3
CAS:Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.Formula:C30H34F3N5OPurezza:97.63%Colore e forma:SolidPeso molecolare:537.62Ref: TM-T63790
1mg70,00€5mg154,00€10mg202,00€25mg384,00€50mg590,00€100mg944,00€1mL*10mM (DMSO)175,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).
Formula:C22H23N3O3Purezza:99.509% - 99.81%Colore e forma:SolidPeso molecolare:377.44USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
Formula:C19H20ClN3O5SPurezza:99.76%Colore e forma:SoildPeso molecolare:437.9
